Genes (34)
Species: human : 34 | |
Human | AICDA | 57379 | activation-induced cytidine deaminase | Differential expression of activation-induced cytidine deaminase (AID) in nodular lymphocyte-predominant and classical Hodgkin lymphoma. | Human | BCL11A | 53335 | B-cell CLL/lymphoma 11A (zinc finger protein) | Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. | Human | FOXP3 | 50943 | forkhead box P3 | The ratio of FOXP3+ regulatory T-cells to granzyme B+ cytotoxic T/NK Cells predicts prognosis in classical Hodgkin lymphoma | Human | SOCS1 | 8651 | suppressor of cytokine signaling 1 | Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation | Human | TRAF1 | 7185 | TNF receptor-associated factor 1 | By immunohistochemistry, we found strong TRAF1 staining in 21 of 25 cases of classical Hodgkin lymphoma. Taken together, the combination of strong cytoplasmic TRAF1 expression and nuclear c-Rel was present in 80% of cases of classical Hodgkin lymphoma (n = 25) but in only 3% of cases of the other malignant lymphomas tested (n = 62). We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and nonmediastinal diffuse large B-cell lymphoma. TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas. | Human | STAT6 | 6778 | signal transducer and activator of transcription 6, interleukin-4 induced | STAT6 overexpression detected in a classical Hodgkins lymphoma cell line | Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | STAT3 signaling is important in the pathogenesis of classical Hodgkin lymphoma | Human | SPI1 | 6688 | spleen focus forming virus (SFFV) proviral integration oncogene | Loss of PU.1 expression is associated with defective immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease. | Human | SDC1 | 6382 | syndecan 1 | The aim of the present study was to assess expression of the B-cell-related antigens CD20, CD79a, and CD138 in classical Hodgkin lymphoma using a tissue microarray consisting of 330 classical Hodgkin lymphoma cases. | Human | CCL22 | 6367 | chemokine (C-C motif) ligand 22 | Macrophage-derived chemokine expression in classical Hodgkin;s lymphoma: application of tissue microarrays. | Human | REL | 5966 | v-rel avian reticuloendotheliosis viral oncogene homolog | TRAF1 expression and c-Rel activation are useful adjuncts in distinguishing classical Hodgkin lymphoma from a subset of morphologically or immunophenotypically similar lymphomas. Taken together, the combination of strong cytoplasmic TRAF1 expression and nuclear c-Rel was present in 80% of cases of classical Hodgkin lymphoma (n = 25) but in only 3% of cases of the other malignant lymphomas tested (n = 62). We demonstrate that the expression of TRAF1 and activated c-Rel, two proteins that function in signaling events downstream of activated CD30 in Reed-Sternberg cells, reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and nonmediastinal diffuse large B-cell lymphoma. significantly higher positivity of c-REL protein expression in Reed-Sternberg cells in classic Hodgkin lymphoma was seen compared with positivity of lymphocytic and histiocytic (L&H) cells in nodular lymphocyte predominant Hodgkin lymphoma REL rather than BCL11A may be the target of the 2p13 alterations in classical Hodgkin Lymphoma Nuclear staining for c-Rel, a pattern consistent with NFkappaB activation, was observed in the Reed-Sternberg cells in 23 of 25 cases of classical Hodgkin lymphoma but only in 1 of 15 cases of anaplastic large cell lymphoma and 3 of 15 cases of nodular lymphocyte predominant Hodgkin lymphoma. Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma. | Human | POU2F2 | 5452 | POU class 2 homeobox 2 | Cases of classical Hodgkin;s lymphoma variably expressed the Pax-5, Oct-1, Oct-2, and BOB.1. We analyzed the expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in 109 cases, including non-Hodgkin;s lymphomas of B- and T-lineage, classical Hodgkin;s lymphomas, and nodular lymphocyte predominant Hodgkin;s lymphomas. These findings indicate that genomic imbalances or rearrangements are not a cause of PU.1, BOB1, and OCT2 deficiency in cHL and argue for another mechanism underlying this phenomenon. Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription. Ectopic expression of both Oct2 and PU.1 in a cHL cell line potentiated endogenous PU.1 and SYK expression after 5-aza-dC treatment. It has previously been demonstrated that in cultured and in situ tumour cells of classical Hodgkin lymphoma (cHL), the immunoglobulin (Ig) promoter is inactive and its transcription factors Oct2 and/or BOB.1/OBF.1 are down-regulated. B-cell transcription factor expression in the gray zone cases more closely resembled MLBCL than cHL with expression of Pax5, Oct2, and BOB.1 in all but 1 case studied (14 of 15). Furthermore, they demonstrate that LRCHL is distinct from NLPHL and that it is closely related to the mixed cellularity CHL (MCHL) in respect of BSAP, BOB.1, and Oct2 expression. | Human | PAX5 | 5079 | paired box 5 | METHODS: Immunohistochemical method was used to detect the expression of B-cell-specific activator protein (BSAP) and CD(20) in 33 paraffin-embedded tissues of classical Hodgkin lymphoma (cHL). OBJECTIVE: To explore the expression of B-cell-specific activator protein (BSAP) of H/RS cell in classical Hodgkin;s lymphoma (cHL). | Human | LGALS1 | 3956 | lectin, galactoside-binding, soluble, 1 | Gal1 and c-Jun serve as diagnostic biomarkers that delineate classical Hodgkin lymphoma and anaplastic large cell lymphoma from other lymphomas with shared morphologic and/or molecular features | Human | JUNB | 3726 | jun B proto-oncogene | In this study we surveyed JunB expression in a variety of CD30+ lymphoma types including 42 cases of anaplastic large cell lymphoma, 36 classical Hodgkin lymphoma, 15 cutaneous anaplastic large cell lymphoma, and 11 CD30+ diffuse large B-cell lymphoma. JunB was also expressed in all cases of classical Hodgkin lymphoma, cutaneous anaplastic large cell lymphoma and CD30+ diffuse large B-cell lymphoma, and in lymphomatoid papulosis. | Human | IRF4 | 3662 | interferon regulatory factor 4 | MUM1/IRF4 is expressed in most cases of classical Hodgkin's lymphoma and shows that lack of this expression in a minority of cases may be a potential adverse prognostic factor | Human | IL13 | 3596 | interleukin 13 | The role of interleukin 13 in classical Hodgkin lymphoma. | Human | ID2 | 3398 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | ID2, which can inactivate E2A and perhaps PAX5, is not detectable in normal B cells but is strongly and uniformly expressed in Hodgkin-Reed/Sternberg (HRS) cells of all cases of classical Hodgkin's lymphoma (HL) ID2 protein was expressed in 83.3% of this group of classical Hodgkin lymphoma, staining strongly in both cytoplasm and nucleus of the Hodgkin and Reed-Sternberg (HRS) cells, and was positively correlated with EBV-LMP1 | Human | HLA-G | 3135 | | induction of HLA-G protein expression in Hodgkin-Reed-Sternberg cells contributes to the modulation of immune responses observed in classical Hodgkin's lymphoma | Human | GATA2 | 2624 | GATA binding protein 2 | The early transcription factor GATA-2 is expressed in classical Hodgkin;s lymphoma. | Human | CCR7 | 1236 | chemokine (C-C motif) receptor 7 | Recent results from our laboratory present evidence for the involvement of CCR7 in the dissemination of neoplastic cells in classic Hodgkin disease. | Human | CDK9 | 1025 | cyclin-dependent kinase 9 | However, at the mRNA level, an imbalance in the CDK9/CYCLIN T1 ratio was found in follicular lymphoma and diffuse large B-cell lymphomas with germinal centre phenotype, and in the cell lines of classical Hodgkin;s lymphomas, Burkitt;s lymphomas, and anaplastic large cell lymphoma, in comparison with reactive lymph nodes. | Human | CDK6 | 1021 | cyclin-dependent kinase 6 | Cyclin D1, but not its enzyme Cdk6, was also depleted after the CHL treatments; the depletions were associated with elevations of G0/G1 cells. | Human | CD79B | 974 | CD79b molecule, immunoglobulin-associated beta | Using bisulfite genomic sequencing we found that in microdissected HRS cells of primary cHL SYK, BOB.1/OBF.1, and CD79B promoters were also hypermethylated. We assessed the expression and methylation status of CD19, CD20, CD79B, SYK, PU.1, BOB.1/OBF.1, BCMA, and LCK, all of which are typically down-regulated in cHL. | Human | MS4A1 | 931 | membrane-spanning 4-domains, subfamily A, member 1 | Further remarks on the expression of CD20 in classical Hodgkin;s lymphomas. The aim of the present study was to assess expression of the B-cell-related antigens CD20, CD79a, and CD138 in classical Hodgkin lymphoma using a tissue microarray consisting of 330 classical Hodgkin lymphoma cases. The neoplastic cells in classical Hodgkin disease (Reed-Sternberg cells) are of B-lymphoid origin, but they lack many markers of this cell lineage, for example, immunoglobulin, CD20, and B-cell-associated transcription factors. Prognostic significance of CD20 expression in classical Hodgkin lymphoma: a clinicopathological study of 119 cases. |
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