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Details
Link-It Detail - Disease - Childhood Leukemia
Debug Stats
  • ### Total Build Time: 98 ms 43.600 KB
  • CONCEPT_NAME gt=3 ms Completed: 3 ms rowSize= 334 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=1 ms Completed: 1 ms rowSize= 1.165 KB
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=49 ms Completed: 49 ms rowSize= 10.723 KB
  • CONCEPT_GENES gt=42 ms Completed: 42 ms rowSize= 30.163 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.152 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Childhood Leukemia C1332977
Definition (1)

Leukemia is cancer of the white blood cells. It is the most common type of childhood cancer.

Your blood cells form in your bone marrow. White blood cells help your body fight infection. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. Leukemia can develop quickly or slowly. Acute leukemia is a fast growing type while chronic leukemia grows slowly. Children with leukemia usually have one of the acute types.

Risk factors for childhood leukemia include having a brother or sister with leukemia, having certain genetic disorders and having had radiation or chemotherapy. Treatment often cures childhood leukemia. Treatment options include chemotherapy, other drug therapy and radiation. In some cases bone marrow and blood stem cell transplantation might help.

NIH: National Cancer Institute

Relationships (22)

Relation Types:
diso_​to_​anat : 8
diso_​to_​diso : 14


Relationships:
is_​abnormal_​cell_​of_​disease : 4
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 1
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 1
is_​not_​finding_​of_​disease : 1
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 5
related_​to : 7
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Bone Marrow C0005953
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATis_abnormal_cell_of_diseaseimg Leukemic Cell C1517806
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_DISOisaimg AGL, childhood C0220621
DISO_to_DISOisaimg ALL, Childhood C0023452
DISO_to_DISOisaimg ALL, L3 childhood C0279582
DISO_to_DISOrelated_toimg Acute lymphocytic leukemia C0023449
DISO_to_DISOrelated_toimg Blood and Blood Disorders C1456636
DISO_to_DISOisaimg Childhood CML C1327920
DISO_to_DISOis_finding_of_diseaseimg Childhood Lesion C1880068
DISO_to_DISOrelated_toimg Chronic Lymphocytic Leukemia C0023434
DISO_to_DISOisaimg LEUKAEMIA NEONATAL C0235813
DISO_to_DISOrelated_toimg Leukemia C0023418
DISO_to_DISOrelated_toimg Leukemia, Lymphocytic, Chronic, B-Cell C0023434
DISO_to_DISOrelated_toimg Leukemia, Myelocytic, Acute C0023467
DISO_to_DISOrelated_toimg Leukemia, Myelogenous, Chronic, BCR-ABL Positive C0023473
DISO_to_DISOis_not_finding_of_diseaseimg Solid Growth Pattern C1336028
Genes (21)

Species:
human : 21
SpeciesGeneGeneIdGene NameEvidence
HumanPRAME23532preferentially expressed antigen in melanoma
img GENERIF, Score=913, Pubmed Id: 16860864, UMLKSK CUI: C1332977
HumanMVP9961major vault protein
img NCI, Score=801, Pubmed Id: 9490695, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 16086885, UMLKSK CUI: C1332977
HumanAKR1C38644aldo-keto reductase family 1, member C3
img GENERIF, Score=734, Pubmed Id: 18339682, UMLKSK CUI: C1332977
HumanWT17490Wilms tumor 1
img GENERIF, Score=913, Pubmed Id: 16876863, UMLKSK CUI: C1332977
HumanTPMT7172thiopurine S-methyltransferase
img NCI, Score=801, Pubmed Id: 12021625, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 10997970, UMLKSK CUI: C1332977
HumanTP537157tumor protein p53
img GENERIF, Score=983, Pubmed Id: 11764099, UMLKSK CUI: C1332977
HumanTCF36929transcription factor 3
img NCI, Score=801, Pubmed Id: 7894030, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 10086727, UMLKSK CUI: C1332977
HumanPTPN115781protein tyrosine phosphatase, non-receptor type 11
img NCI, Score=801, Pubmed Id: 15116097, UMLKSK CUI: C1332977
HumanPBX15087pre-B-cell leukemia homeobox 1
img NCI, Score=801, Pubmed Id: 7894030, UMLKSK CUI: C1332977
HumanNBN4683nibrin
img GENERIF, Score=1000, Pubmed Id: 18691878, UMLKSK CUI: C1332977
HumanMTRR45525-methyltetrahydrofolate-homocysteine methyltransferase reductase
img GENERIF, Score=913, Pubmed Id: 18610829, UMLKSK CUI: C1332977
HumanMTHFR4524methylenetetrahydrofolate reductase (NAD(P)H)
img GENERIF, Score=734, Pubmed Id: 18339682, UMLKSK CUI: C1332977
HumanMLLT44301myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
img NCI, Score=801, Pubmed Id: 12067721, UMLKSK CUI: C1332977
HumanMDM24193MDM2 oncogene, E3 ubiquitin protein ligase
img GENERIF, Score=983, Pubmed Id: 11764099, UMLKSK CUI: C1332977
HumanIGFBP33486insulin-like growth factor binding protein 3
img NCI, Score=801, Pubmed Id: 11340377, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 9935146, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 9935146, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 11340377, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 11065014, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 11340377, UMLKSK CUI: C1332977
img NCI, Score=801, Pubmed Id: 9935146, UMLKSK CUI: C1332977
HumanHFE3077hemochromatosis
img GAD, Score=1000, Pubmed Id: 10627122, UMLKSK CUI: C1332977
HumanERCC12067excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
img NCI, Score=801, Pubmed Id: 9827920, UMLKSK CUI: C1332977
HumanNQO11728NAD(P)H dehydrogenase, quinone 1
img GENERIF, Score=1000, Pubmed Id: 17332311, UMLKSK CUI: C1332977
HumanCYP1A11543cytochrome P450, family 1, subfamily A, polypeptide 1
img GENERIF, Score=1000, Pubmed Id: 15298960, UMLKSK CUI: C1332977
HumanCDKN1B1027cyclin-dependent kinase inhibitor 1B (p27, Kip1)
img GENERIF, Score=1000, Pubmed Id: 16526056, UMLKSK CUI: C1332977
HumanRUNX1861runt-related transcription factor 1
img GENERIF, Score=902, Pubmed Id: 14523475, UMLKSK CUI: C1332977
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1332977Childhood Leukemia0self