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Genes (21)
Species: human : 21 | |
Human | PRAME | 23532 | preferentially expressed antigen in melanoma | Overexpression of PRAME was associated with childhood acute leukemia | Human | MVP | 9961 | major vault protein | BACKGROUND : Previous studies revealed that lung resistance protein (LRP) and multidrug resistance-associated protein (MRP) relate to drug resistance of childhood leukemia, which is not caused by only one mechanism. Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. | Human | AKR1C3 | 8644 | aldo-keto reductase family 1, member C3 | The maternal methylenetetrahydrofolate reductase A1298C polymorphism was found to be an effect modifier of the maternal intron 4 polymorphism of the AKR1C3 gene and the childhood leukemia risk | Human | WT1 | 7490 | Wilms tumor 1 | High levels of WT1 expression is associated with childhood acute leukemia | Human | TPMT | 7172 | thiopurine S-methyltransferase | This study examined the role of thiopurine methyltransferase (TPMT) polymorphism in the metabolism and clinical effects of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease and childhood leukemia. These results indicate that polymerase chain reaction-based assays give reliable and robust results for the detection of TPMT deficiency, but that caution should be exercised in relying exclusively on DNA obtained from lymphoblasts in childhood leukaemia. | Human | TP53 | 7157 | tumor protein p53 | higher expression in childhood leukemias with poor prognosis compared to long-term survivors | Human | TCF3 | 6929 | transcription factor 3 | Our observations suggest that there could be heterogeneity in the molecular events among adult leukemias carrying the t(1;19) and that the E2A/PBX1 fusion formation might also be associated with an adverse treatment outcome in adult leukemias as in childhood leukemias. Identification of a novel molecular partner of the E2A gene in childhood leukemia. | Human | PTPN11 | 5781 | protein tyrosine phosphatase, non-receptor type 11 | Recent identification of SHP-2 mutations in childhood leukemia further emphasizes the importance of SHP-2 regulation in hematopoietic cells. | Human | PBX1 | 5087 | pre-B-cell leukemia homeobox 1 | Our observations suggest that there could be heterogeneity in the molecular events among adult leukemias carrying the t(1;19) and that the E2A/PBX1 fusion formation might also be associated with an adverse treatment outcome in adult leukemias as in childhood leukemias. | Human | NBN | 4683 | nibrin | The TT genotype of c.2071-30A>T polymorphism was higher in leukaemia patients than in controls. results suggest that some specific haplotypes of the NBS1 gene may be associated with childhood leukaemia | Human | MTRR | 4552 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | polymorphic variants of genes GSTT1, GSTM1, NAT2 and MTRR can modulate the risk of childhood acute leukemia, residents of European part of Russia | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | The maternal methylenetetrahydrofolate reductase A1298C polymorphism was found to be an effect modifier of the maternal intron 4 polymorphism of the aldo-keto reductase family 1 member C3 gene and the childhood leukemia risk | Human | MLLT4 | 4301 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | AF6 is a recurrent fusion partner of MLL, the human homolog of Drosophila trithorax chromatin remodeling protein that is involved in childhood leukemia and mixed lineage leukemia. | Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | higher expression in childhood leukemias with poor prognosis compared to long-term survivors | Human | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | Since insulin-like growth factor-I (IGF-I) mediates the effect of growth hormone and has been positively associated with prostate cancer, we have evaluated the role of this hormone and its principal binding protein, IGFBP-3, in the aetiology of childhood leukaemia. CONCLUSION: The presented empirical evidence in conjunction with the fact that IGFBP-3 modulates IGF-1 and IGF-2 bioavailability and is likely to have proapoptotic effects makes this compound a plausible independent predictor of survival from childhood leukemia. OBJECTIVE: To investigate whether the three principal components of the insulin-like growth factor (IGF) system, IGF-1, IGF-2 and IGF binding protein-3 (IGFBP-3), are associated with survival from childhood leukemia. OBJECTIVE: Insulin-like growth factor-1 (IGF-1) and its principal binding protein-3 (IGFBP-3) are central in the mediation of the effect of growth hormone, and the IGF system has been reported to play a role in the pathogenesis of childhood leukemia. There was no significant association between IGF-I and the likelihood of childhood leukaemia, but an increment of 1 microg/ml of IGFBP-3 was associated with a substantial and statistically significant reduction of childhood leukaemia by 28% (95% confidence interval 7% to 45%). Because IGFBP-3 is essentially a binding protein, we interpret our findings as indicating that bioavailable IGF-I may play an important role in the aetiology of childhood leukaemia. Insulin-like growth factor binding protein-3 predicts survival from acute childhood leukemia. | Human | HFE | 3077 | hemochromatosis | Title:The C282Y mutation of HFE is another male-specific risk factor for childhood acute lymphoblastic leukemia|Association:Y|Conclusion: | Human | ERCC1 | 2067 | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | This is the first report describing a mutation at the ERCC1 gene in acute childhood leukaemia. | Human | NQO1 | 1728 | NAD(P)H dehydrogenase, quinone 1 | This is the first study showing robust (to bias due to population structure) evidence that the NQO1 C609T variant is a risk factor for childhood leukemia | Human | CYP1A1 | 1543 | cytochrome P450, family 1, subfamily A, polypeptide 1 | The risk of childhood leukemia showed no evidence of association between cytochrome P-450 1A1 genotype frequencys and case control status | Human | CDKN1B | 1027 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | Mutations in the 3' untranslated region of Kip1 could provide an additional tool for risk classification in childhood leukemia | Human | RUNX1 | 861 | runt-related transcription factor 1 | Amplification of this gene in childhood acute lymphoblsatic leukemia is associatd with poor outcome |
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