Mouse | LOC51190 | 51190 | | We report here that acute exposure of WEHI-231 cells (murine B-cell lymphoma) to OE activates neutral sphingomyelinase, induces ceramide production and increases intracellular reactive oxygen species. |
Mouse | IGK@ | 50802 | | The kappa immunoglobulin (Igk) light chain locus is transcriptionally silent in the mouse B-cell lymphoma 70Z/3. |
Mouse | TNFRSF13B | 23495 | tumor necrosis factor receptor superfamily, member 13B | Murine TACI was subsequently isolated from the mouse B lymphoma A20 cells. |
Mouse | TNFSF13B | 10673 | tumor necrosis factor (ligand) superfamily, member 13b | TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. TNF deficiency in BAFF-Tg mice also led to a surprisingly high incidence of B cell lymphomas (>35%), which most likely resulted from the combined effects of BAFF promotion of neoplastic B cell survival, coupled with lack of protective antitumor defense by TNF. This unique binding profile suggests that a radiolabeled form of BLyS protein may be a useful treatment for B cell neoplasias such as B cell lymphoma and multiple myeloma. |
Mouse | HHCM | 10639 | Mahlavu hepatocellular carcinoma | A B-cell lymphoma was induced in athymic NIH Swiss nu/nu mice by challenging the animals with NIH3T3 cells, previously transfected with a recombinant DNA carrying a human oncogene hhcM, ligated to an SV40 promoter with a neomycin-resistance marker. |
Mouse | GSTO1 | 9446 | glutathione S-transferase omega 1 | Elimination of the differential chemoresistance between the murine B-cell lymphoma LY-ar and LY-as cell lines after arsenic (As2O3) exposure via the overexpression of gsto1 (p28). |
Mouse | TNFSF9 | 8744 | tumor necrosis factor (ligand) superfamily, member 9 | The B lymphoma M12 expresses low levels of 4-1BB-L but can be induced to express higher levels by treatment of the B cells with cAMP, which also induces B7-1 and B7-2 in these cells. |
Mouse | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | In this study, we report that ligation of the G-protein-coupled chemokine receptor CXCR4 by SDF-1/CXCL12 has no effect on the tyrosine phosphorylation of SHIP in the murine B cell lymphoma A20. |
Mouse | CSDE1 | 7812 | cold shock domain containing E1, RNA-binding | Murine leukemia virus proviral insertions between the N-ras and unr genes in B-cell lymphoma DNA affect the expression of N-ras only. Thus, altogether our findings indicate that overexpression of N-ras plays a role in development of murine leukemia virus-induced B-cell lymphomas, leaving the expression of the tightly linked unr gene unaltered. |
Mouse | YWHAB | 7529 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | Two members of this family (cortactin and HS1) were differentially expressed in murine B lymphoid tumor cell lines; both were detected in plasmacytoma cell lines, however HS1 was additionally detected in pre-B lymphoma and B lymphoma cell lines. |
Mouse | WNT5A | 7474 | wingless-type MMTV integration site family, member 5A | Wnt5a hemizygous mice develop myeloid leukemias and B cell lymphomas that are clonal in origin and display loss of Wnt5a function in tumor tissues. Wnt5a hemizygous mice develop myeloid leukemias and B cell lymphomas that are clonal in origin and display loss of Wnt5a function in tumor tissues. |
Mouse | UNG | 7374 | uracil-DNA glycosylase | Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. |
Mouse | MAPK9 | 5601 | mitogen-activated protein kinase 9 | Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase. |
Mouse | PRKCA | 5578 | protein kinase C, alpha | Studies utilizing the overexpression of individual isoforms indicated that both PKC-alpha and -delta promote a number of biological effects, including inhibition of DNA synthesis associated with rearrangements of the actin cytoskeleton in the murine B-cell lymphoma (Baf3), differentiation of the murine promyelocyte line 32D, and activation of MAP kinase in CHO fibroblasts. |
Mouse | POU2F2 | 5452 | POU class 2 homeobox 2 | 1.3E2, a variant of the B lymphoma 70Z/3, defective in activation of NF-kappa B and OTF-2. |
Mouse | MYBL1 | 4603 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | A-myb rescues murine B-cell lymphomas from IgM-receptor-mediated apoptosis through c-myc transcriptional regulation. |
Mouse | MIF | 4282 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Using the Emu-Myc lymphoma mouse model, we demonstrate that loss of MIF markedly delays the onset of B-cell lymphoma development in vivo. |
Mouse | SMAD3 | 4088 | SMAD family member 3 | Overexpression of Runx3 in mice increased germ-line alpha (GLalpha) transcription, and transcription was further augmented when B lymphoma and LPS-activated murine spleen cells were co-transfected with Smad3/4. |
Mouse | IGJ | 3512 | immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides | Expression of the immunoglobulin J chain in a murine B lymphoma is driven by autocrine production of interleukin 2. |
Mouse | ID2 | 3398 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | Surprisingly, despite these connections, Emu-Myc mice lacking Id2 succumb to lethal B-cell lymphoma at rates comparable with wild-type Emu-Myc transgenics. |
Mouse | ICAM2 | 3384 | intercellular adhesion molecule 2 | ICAM-2 is expressed on a variety of leukocyte cell lines, including T and B lymphoma, mastocytoma, and macrophage lines. |
Mouse | TLX1 | 3195 | T-cell leukemia homeobox 1 | HOX11-transgenic mice (IgHmu-HOX11(Tg))-expressing HOX11 in the B-cell compartment develop B-cell lymphomas with extended latency. |
Mouse | HCLS1 | 3059 | hematopoietic cell-specific Lyn substrate 1 | Two members of this family (cortactin and HS1) were differentially expressed in murine B lymphoid tumor cell lines; both were detected in plasmacytoma cell lines, however HS1 was additionally detected in pre-B lymphoma and B lymphoma cell lines. |
Mouse | H2AFX | 3014 | H2A histone family, member X | Mice deficient for both H2AX and p53 (H(delta/delta)P(-/-)) rapidly developed immature T and B lymphomas and solid tumors. Moreover, H2AX haploinsufficiency caused genomic instability in normal cells and, on a p53-deficient background, early onset of various tumors including more mature B lymphomas. |
Mouse | DAXX | 1616 | death-domain associated protein | The carboxy-terminal portion of Daxx functions as a dominant-negative inhibitor of TGF-beta-induced apoptosis in B-cell lymphomas, and antisense oligonucleotides to Daxx inhibit TGF-beta-induced apoptosis in mouse hepatocytes. |