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Details
Link-It Detail - Disease - Adenocarcinoma of Cardioesophageal junction
Debug Stats
  • ### Total Build Time: 112 ms 16.644 KB
  • CONCEPT_NAME gt=5 ms Completed: 5 ms rowSize= 384 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 971 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=5 ms Completed: 5 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=85 ms Completed: 85 ms rowSize= 12.542 KB
  • CONCEPT_GENES gt=9 ms Completed: 9 ms rowSize= 1.531 KB
  • CONCEPT_XREFS gt=7 ms Completed: 7 ms rowSize= 1.177 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Adenocarcinoma of Cardioesophageal junction C1332166
Definition (1)
An adenocarcinoma that arises from and straddles the junction of the stomach and esophagus. The category of adenocarcinomas of the gastroesophageal junction also includes the majority of adenocarcinomas previously called gastric cardia adenocarcinomas. Squamous cell carcinomas that affect or cross the junction of the stomach and esophagus are classified as carcinomas of the distal esophagus. Adenocarcinoma of the gastroesophageal junction occurs more often in Caucasian middle aged and elderly males. Clinical signs and symptoms include dysphagia, abdominal pain, and weight loss. The prognosis depends on the completeness of the surgical resection, the number of lymph nodes involved by cancer, and the presence or absence of postoperative complications. The presence of TP53 mutations indicates worse prognosis.
Relationships (25)

Relation Types:
diso_​to_​anat : 14
diso_​to_​diso : 11


Relationships:
is_​abnormal_​cell_​of_​disease : 6
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 1
is_​not_​abnormal_​cell_​of_​disease : 4
is_​not_​finding_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 2
may_​be_​associated_​disease_​of_​disease : 1
may_​be_​finding_​of_​disease : 4
may_​be_​molecular_​abnormality_​of_​disease : 2
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Adenocarcinoma Cell C1510779
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Digestive System C0012240
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Esophagogastric Junction C0014871
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Squamous Cell C1518245
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Stromal Cell C1518246
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Glandular Cell C1513973
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Squamous Cell C1514101
DISO_to_DISOmay_be_finding_of_diseaseimg Abdominal Pain C0000737
DISO_to_DISOis_not_finding_of_diseaseimg Benign Cellular Infiltrate C1332480
DISO_to_DISOmay_be_finding_of_diseaseimg Body Weight decreased C0043096
DISO_to_DISOis_finding_of_diseaseimg Carcinomatous Component Present C1707292
DISO_to_DISOmay_be_finding_of_diseaseimg Deglutition Disorders C0011168
DISO_to_DISOis_finding_of_diseaseimg Epithelial Component Present C1707933
DISO_to_DISOmay_be_associated_disease_of_diseaseimg Gastroesophageal Reflux C0017168
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg Inactivation of p53 Tumor-Suppressor Gene C1515171
DISO_to_DISOmay_be_finding_of_diseaseimg Intestinal Metaplasia C0334037
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg MDM2 Gene Mutation C1518117
DISO_to_DISOis_not_finding_of_diseaseimg Mixed Neoplastic Glandular and Squamous Cell Population C1881876
Genes (1)

Species:
human : 1
SpeciesGeneGeneIdGene NameEvidence
HumanAXIN18312axin 1
img GENERIF, Score=983, Pubmed Id: 14970870, UMLKSK CUI: C1332166
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1332166Adenocarcinoma of Cardioesophageal junction0self