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Details
Link-It Detail - Disease - ALCL, ALK+
Debug Stats
  • ### Total Build Time: 131 ms 24.842 KB
  • CONCEPT_NAME gt=7 ms Completed: 7 ms rowSize= 318 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 516 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=2 ms Completed: 2 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=100 ms Completed: 100 ms rowSize= 15.788 KB
  • CONCEPT_GENES gt=16 ms Completed: 16 ms rowSize= 7.024 KB
  • CONCEPT_XREFS gt=5 ms Completed: 5 ms rowSize= 1.145 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
ALCL, ALK+ C1332079
Definition (1)
A T-cell peripheral lymphoma composed of usually large, pleomorphic, CD30 positive T-lymphocytes with abundant cytoplasm characterized by the presence of a translocation involving the ALK gene and expression of ALK fusion protein. Most patients present with peripheral and/or abdominal lymphadenopathy, and often have advanced disease and extranodal involvement.
Relationships (53)

Relation Types:
diso_​to_​anat : 26
diso_​to_​diso : 26
diso_​to_​phen : 1


Relationships:
is_​abnormal_​cell_​of_​disease : 8
is_​associated_​anatomic_​site_​of : 1
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 6
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 2
is_​not_​normal_​cell_​origin_​of_​disease : 4
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 1
may_​be_​abnormal_​cell_​of_​disease : 3
may_​be_​cytogenetic_​abnormality_​of_​disease : 9
may_​be_​finding_​of_​disease : 3
may_​be_​molecular_​abnormality_​of_​disease : 11
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Activated Mature Cytotoxic T-Lymphocyte C1515880
DISO_to_ANATis_abnormal_cell_of_diseaseimg Anaplastic Large T-Lymphocyte C1515967
DISO_to_ANATis_abnormal_cell_of_diseaseimg Anaplastic T-Lymphocyte with Horseshoe-Shaped Nucleus C1512330
DISO_to_ANATis_abnormal_cell_of_diseaseimg Atypical lymphocyte C0221277
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Cells, Reed-Sternberg C0085133
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg HEMOLYMPHORETICULAR TISSUE C1512398
DISO_to_ANATis_associated_anatomic_site_ofimg Hematopoietic and Lymphatic System C1512394
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Hematopoietic and Lymphoid Cell C1512385
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg Hodgkin's-Like Cell C1512477
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Lymphatic System C0024235
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Lymphatic Tissue C0024296
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Lymphocyte C0024264
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Mature T-Cell C1513029
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Myeloid Cells C0887899
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic B-Lymphocyte C1513929
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Hematopoietic and Lymphoid Cell C1513983
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Lymphocyte C1514011
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell C1514110
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Peripheral (Post-Thymic) T-Lymphocyte and NK-Cell C1519006
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Plasma Cells C0032112
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Precursor NK-Cell C1514302
DISO_to_ANATis_not_normal_cell_origin_of_diseaseimg Precursor T-Lymphoblast C1515138
DISO_to_ANATmay_be_abnormal_cell_of_diseaseimg R-S-Like Cell C1514809
Genes (4)

Species:
human : 4
SpeciesGeneGeneIdGene NameEvidence
HumanNPM14869nucleophosmin (nucleolar phosphoprotein B23, numatrin)
img GENERIF, Score=1000, Pubmed Id: 16709933, UMLKSK CUI: C1332079
img NCI, Score=801, Pubmed Id: 11707867, UMLKSK CUI: C1332079
HumanCD994267CD99 molecule
img GENERIF, Score=994, Pubmed Id: 16361803, UMLKSK CUI: C1332079
HumanCEBPB1051CCAAT/enhancer binding protein (C/EBP), beta
img GENERIF, Score=1000, Pubmed Id: 16709933, UMLKSK CUI: C1332079
HumanALK238anaplastic lymphoma receptor tyrosine kinase
img GENERIF, Score=1000, Pubmed Id: 12036886, UMLKSK CUI: C1332079
img GENERIF, Score=994, Pubmed Id: 12213716, UMLKSK CUI: C1332079
img GENERIF, Score=1000, Pubmed Id: 16709933, UMLKSK CUI: C1332079
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1332079ALCL, ALK+0self