Mouse | MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis. |
Mouse | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | Here we identify the mouse Fbxw7 gene as a p53-dependent tumour suppressor gene by using a mammalian genetic screen for p53-dependent genes involved in tumorigenesis. Fbxw7+/- mice have greater susceptibility to radiation-induced tumorigenesis, but most tumours retain and express the wild-type allele, indicating that Fbxw7 is a haploinsufficient tumour suppressor gene. |
Mouse | CHEK2 | 11200 | checkpoint kinase 2 | A truncating allele of the cell cycle checkpoint kinase CHK2 is present in 1% of the population, conferring a moderate increase in breast cancer risk, and inactivation of chk2 enhances mammary tumorigenesis in mice with targeted inactivation of brca1. Mammary tumorigenesis following transgenic expression of a dominant negative CHK2 mutant. |
Mouse | DMTF1 | 9988 | cyclin D binding myb-like transcription factor 1 | Loss of Dmp1, an Arf transcriptional activator, leads to spontaneous tumorigenesis in mice, causing death from various forms of cancer by two years of age. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. |
Mouse | DLEC1 | 9940 | deleted in lung and esophageal cancer 1 | Taken together, our results strongly suggest that silencing of DLEC1 expression by promoter hypermethylation and histone deacetylation may be important in NPC tumorigenesis. |
Mouse | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Moreover, the increased proliferation and survival observed in a three-dimensional culture system suggests a role for aberrant RANK signaling during breast tumorigenesis. |
Mouse | HMGA2 | 8091 | high mobility group AT-hook 2 | Click here to display 4 evidence detail records. |
Mouse | ST7 | 7982 | suppression of tumorigenicity 7 | Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. |
Mouse | TRIM25 | 7706 | tripartite motif containing 25 | These data provide an insight into the cell-cycle machinery and tumorigenesis of breast cancer by identifying 14-3-3 sigma as a target for proteolysis by Efp, leading to cell proliferation. |
Mouse | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | Impact of telomerase ablation on TAX_IDal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs. Loss of p53 synergizes with Ku80 to promote tumorigenesis such that all Ku80-/- p53-/- mice succumb to disseminated pro-B-cell lymphoma before three months of age. |
Mouse | XRCC4 | 7518 | X-ray repair complementing defective repair in Chinese hamster cells 4 | Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. |
Mouse | WRN | 7486 | Werner syndrome, RecQ helicase-like | The p21 null/Wrn mutant mice did not show an acceleration of tumorigenesis during the first year of life, suggesting that the p53-dependent G1-S cell cycle checkpoint (which operates via p21) is not involved in Wrn-abetted tumor suppression. Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. |
Mouse | WNT5A | 7474 | wingless-type MMTV integration site family, member 5A | Furthermore, ectopic wnt-5a in MC-T16 uroepithelial cancer cells missing the region of chromosome 3p where wnt-5a has been mapped reverts uroepithelial cell tumorigenesis in athymic nude mice. |
Mouse | UBE3A | 7337 | ubiquitin protein ligase E3A | Click here to display 3 evidence detail records. |
Mouse | THBS2 | 7058 | thrombospondin 2 | Surprisingly, TSP-2 expression was strongly upregulated in the mesenchymal stroma of wild-type mice throughout the consecutive stages of tumorigenesis whereas the angiogenesis factor, vascular endothelial growth factor, was induced predominantly in tumor cells. |
Mouse | ROBO1 | 6091 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | This suggests that Dutt1/Robo1 is a classic tumor suppressor gene requiring inactivation of both alleles to elicit tumorigenesis in these mice. |
Mouse | PTGER1 | 5731 | prostaglandin E receptor 1 (subtype EP1), 42kDa | The EP receptor subtype EP1 mediates the effects of PGE(2) by increasing intracellular calcium levels ([Ca(2+)](i)), whereas antagonism of EP1 has been shown to attenuate tumorigenesis in Apc(Min/+) mice. Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. |
Mouse | MAP2K6 | 5608 | mitogen-activated protein kinase kinase 6 | Here we show that a subtle activation of p38 MAPK is sufficient to suppress tumorigenesis as measured by the ability to form tumors when MKK6-inducible cells were explanted into nude mice. |
Mouse | PPARD | 5467 | peroxisome proliferator-activated receptor delta | Whereas administration of a PPARbeta ligand causes increased small intestinal tumorigenesis in Apc(min/+) mice, PPARbeta-null (Pparb-/-) mice exhibit increased colon polyp multiplicity in colon cancer bioassays, suggesting that ligand activation of this receptor will inhibit colon carcinogenesis. |
Mouse | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | Click here to display 3 evidence detail records. |
Mouse | PLK1 | 5347 | polo-like kinase 1 | Our data suggest that folate deficiency can initiate tumor development, that Mthfr mutation can enhance this phenomenon, and that altered expression of Plk1 and Cdc25c may contribute to folate-dependent intestinal tumorigenesis. |
Mouse | PAX3 | 5077 | paired box 3 | These data suggest that the PAX3-KRAB repressor functions as a DNA-binding-dependent suppressor of the transformed phenotype of ARMS cells, probably via competition with the endogenous PAX3-FKHR oncogene and repression of target genes required for ARMS tumorigenesis. |
Mouse | NOTCH3 | 4854 | notch 3 | Together, these data identify activated Notch3 as a link between signals leading to NF-kappaB activation and T-cell tumorigenesis. |
Mouse | NOTCH1 | 4851 | notch 1 | Click here to display 3 evidence detail records. |
Mouse | MCM7 | 4176 | minichromosome maintenance complex component 7 | Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis. |