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Details
Link-It Detail - Disease - Adenocarcinoma of Large Bowel
Debug Stats
  • ### Total Build Time: 72 ms 54.929 KB
  • CONCEPT_NAME gt=10 ms Completed: 10 ms rowSize= 356 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 535 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=31 ms Completed: 31 ms rowSize= 15.764 KB
  • CONCEPT_GENES gt=29 ms Completed: 29 ms rowSize= 37.062 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.163 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Adenocarcinoma of Large Bowel C1319315
Definition (1)
The most common type of colorectal carcinoma. It is characterized by the presence of malignant glandular epithelial cells invading through the muscularis mucosa into the submucosa. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma.
Relationships (51)

Relation Types:
diso_​to_​anat : 18
diso_​to_​chem : 2
diso_​to_​diso : 29
diso_​to_​gene : 2


Relationships:
gene_​associated_​with_​disease : 2
gene_​product_​malfunction_​associated_​with_​disease : 2
is_​abnormal_​cell_​of_​disease : 6
is_​associated_​anatomic_​site_​of : 2
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 2
is_​normal_​tissue_​origin_​of_​disease : 3
is_​not_​abnormal_​cell_​of_​disease : 4
is_​not_​finding_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 19
may_​be_​finding_​of_​disease : 1
may_​be_​molecular_​abnormality_​of_​disease : 5
Page Size
Current 25
  Page 1 of 3
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_abnormal_cell_of_diseaseimg Adenocarcinoma Cell C1510779
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Colorectal Region C1711309
DISO_to_ANATis_associated_anatomic_site_ofimg Digestive System C0012240
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Glandular Cell C1517548
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Glandular Epithelium C0682578
DISO_to_ANATis_associated_anatomic_site_ofimg Intestines C0021853
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Large Intestinal Mucosa C0734203
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Squamous Cell C1518245
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Stromal Cell C1518246
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Glandular Cell C1513973
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Squamous Cell C1514101
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg CUB and Sushi Domain-Containing Protein 1 C2982398
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg SMAD3 protein, human C0529119
DISO_to_DISOmay_be_molecular_abnormality_of_diseaseimg APC Gene Inactivation C1515857
DISO_to_DISOisaimg APPENDIX CANCER, ADENOCARCINOMA C0238003
DISO_to_DISOisaimg Adenocarcinoma of Cecum C1332866
DISO_to_DISOisaimg Adenocarcinoma of anorectum C3164626
DISO_to_DISOisaimg Adenocarcinoma of colon C0338106
Genes (133)

Species:
human : 132
mouse : 1
Page Size
Current 25
  Page 1 of 6
Prior Page
Current 1
SpeciesGeneGeneIdGene NameEvidence
MouseCD80941CD80 molecule
img NCI, Score=801, Pubmed Id: 10637450, UMLKSK CUI: C1319315
HumanENPP7339221ectonucleotide pyrophosphatase/phosphodiesterase 7
img NCI, Score=801, Pubmed Id: 15824156, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 15824156, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 15824156, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 10496347, UMLKSK CUI: C1319315
HumanPOTED317754POTE ankyrin domain family, member D
img NCI, Score=801, Pubmed Id: 17070643, UMLKSK CUI: C1319315
HumanFOXQ194234forkhead box Q1
img NCI, Score=801, Pubmed Id: 11747606, UMLKSK CUI: C1319315
HumanMUC1694025mucin 16, cell surface associated
img GENERIF, Score=884, Pubmed Id: 18317225, UMLKSK CUI: C1319315
HumanPPP1R1B84152protein phosphatase 1, regulatory (inhibitor) subunit 1B
Click here to display 5 evidence detail records.
HumanREG483998regenerating islet-derived family, member 4
img NCI, Score=801, Pubmed Id: 17184759, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 16086444, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 16086444, UMLKSK CUI: C1319315
HumanEIF5A256648eukaryotic translation initiation factor 5A2
img NCI, Score=801, Pubmed Id: 11161802, UMLKSK CUI: C1319315
HumanSH3GLB151100SH3-domain GRB2-like endophilin B1
img GENERIF, Score=1000, Pubmed Id: 18833585, UMLKSK CUI: C1319315
HumanCHST1150515carbohydrate (chondroitin 4) sulfotransferase 11
img NCI, Score=801, Pubmed Id: 11056388, UMLKSK CUI: C1319315
HumanEMR230817egf-like module containing, mucin-like, hormone receptor-like 2
img NCI, Score=801, Pubmed Id: 12761622, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 12761622, UMLKSK CUI: C1319315
HumanBBC327113BCL2 binding component 3
img NCI, Score=801, Pubmed Id: 15547745, UMLKSK CUI: C1319315
HumanAMACR23600alpha-methylacyl-CoA racemase
Click here to display 5 evidence detail records.
HumanRPH3A22895rabphilin 3A homolog (mouse)
img GENERIF, Score=1000, Pubmed Id: 17981610, UMLKSK CUI: C1319315
HumanMETAP210988methionyl aminopeptidase 2
img NCI, Score=801, Pubmed Id: 15102683, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 15102683, UMLKSK CUI: C1319315
img GENERIF, Score=734, Pubmed Id: 15102683, UMLKSK CUI: C1319315
HumanCYSLTR110800cysteinyl leukotriene receptor 1
img GENERIF, Score=983, Pubmed Id: 15705869, UMLKSK CUI: C1319315
HumanCXCR610663chemokine (C-X-C motif) receptor 6
img NCI, Score=801, Pubmed Id: 15736401, UMLKSK CUI: C1319315
HumanDEAF110522DEAF1 transcription factor
img NCI, Score=801, Pubmed Id: 11705868, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 11705868, UMLKSK CUI: C1319315
HumanMSLN10232mesothelin
img NCI, Score=801, Pubmed Id: 12827615, UMLKSK CUI: C1319315
HumanZBTB3310009zinc finger and BTB domain containing 33
img GENERIF, Score=901, Pubmed Id: 15781635, UMLKSK CUI: C1319315
HumanMVP9961major vault protein
img NCI, Score=801, Pubmed Id: 11593059, UMLKSK CUI: C1319315
HumanCCNB29133cyclin B2
Click here to display 8 evidence detail records.
HumanTP638626tumor protein p63
img NCI, Score=801, Pubmed Id: 11727253, UMLKSK CUI: C1319315
HumanRFXANK8625regulatory factor X-associated ankyrin-containing protein
img NCI, Score=801, Pubmed Id: 11836625, UMLKSK CUI: C1319315
img NCI, Score=801, Pubmed Id: 11836625, UMLKSK CUI: C1319315
HumanPLA2G108399phospholipase A2, group X
img GENERIF, Score=884, Pubmed Id: 12048163, UMLKSK CUI: C1319315
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C1319315Adenocarcinoma of Large Bowel0self