Mouse | FGR | 2268 | feline Gardner-Rasheed sarcoma viral oncogene homolog | With an immune complex kinase assay in a monocytic leukemia cell line, 2H2 monoclonal antibody was shown to precipitate a 59-kDa protein that corresponds in molecular mass to murine Fgr. |
Human | CCL3L3 | 414062 | chemokine (C-C motif) ligand 3-like 3 | This protein was not found in culture supernatants or cell lysates of monocytic leukemia cells and HL-60 cells, although LD78 transcripts were found in those cells. |
Human | RAB7B | 338382 | RAB7B, member RAS oncogene family | RT-PCR or Western blot analysis of Rab7b expression shows that Rab7b is selectively expressed in monocytes, monocyte-derived immature dendritic cells (DCs), and promyeloid or monocytic leukemia cell lines. |
Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Treatment of U937 monocytic leukemia cells with rapamycin (10 nmol/L) in conjunction with a minimally toxic concentration of UCN-01 (100 nmol/L) for 36 hours resulted in marked potentiation of mitochondrial injury (i.e., loss of mitochondrial membrane potential and cytosolic release of cytochrome c, AIF, and Smac/DIABLO), caspase activation, and apoptosis. |
Human | MRAS | 22808 | muscle RAS oncogene homolog | Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. |
Human | ABI1 | 10006 | abl-interactor 1 | t(10;11)(p11.2;q23) involving MLL and this gene is associated with congenital acute monocytic leukemia |
Human | MVP | 9961 | major vault protein | In conclusion, we report that LRP is rather a marker of monocytic lineage than a prognostic index for MDR and we suggest that detection of LRP by ICC could be an argument for the diagnosis of monoblastic and monocytic leukemias. |
Human | CD83 | 9308 | CD83 molecule | The efficient generation of CD83 positive immunocompetent dendritic cells from CD14 positive acute myelomonocytic or monocytic leukemia cells in vitro. |
Human | AIFM1 | 9131 | apoptosis-inducing factor, mitochondrion-associated, 1 | Treatment of U937 monocytic leukemia cells with rapamycin (10 nmol/L) in conjunction with a minimally toxic concentration of UCN-01 (100 nmol/L) for 36 hours resulted in marked potentiation of mitochondrial injury (i.e., loss of mitochondrial membrane potential and cytosolic release of cytochrome c, AIF, and Smac/DIABLO), caspase activation, and apoptosis. |
Human | MLLT10 | 8028 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysema. Monocytic leukemias with CALM/AF10 fusion are frequently associated with mediastinal invasion. |
Human | MYST3 | 7994 | | In addition, fluorescence in situ hybridization analysis suggested a rearrangement in the monocytic leukemia zinc finger (MOZ) gene, located in the 8p11 region of chromosome 8. We show that a zebrafish ortholog of the human oncogenic histone acetyltransferase MOZ (monocytic leukemia zinc finger) is required for specifying segmental identity in the second through fourth pharyngeal arches. |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | resistance of acute monocytic leukemia cells to calcitriol-induced differentiation correlates with impaired nuclear localization of vitamin D receptor, but not with its total expression in the cells |
Human | TXN | 7295 | thioredoxin | We therefore investigated the expression of redox-regulating proteins such as glutaredoxin (GRX) and thioredoxin (TRX) during the differentiation of murine monocytic leukemia cell line M1 cells and human monocytic leukemia cell line U937 cells. |
Human | CCL3L1 | 6349 | chemokine (C-C motif) ligand 3-like 1 | This protein was not found in culture supernatants or cell lysates of monocytic leukemia cells and HL-60 cells, although LD78 transcripts were found in those cells. |
Human | SAA1 | 6288 | serum amyloid A1 | Because SAA synthesis at the protein level in such cells has never been analyzed quantitatively, in this study an enzyme-linked immunosorbent assay was generated with a detection level sufficiently high to measure SAA concentrations in the culture supernatants of the human monocytic leukaemia cell line THP-1. |
Human | SAA@ | 6287 | serum amyloid A1 cluster | Because SAA synthesis at the protein level in such cells has never been analyzed quantitatively, in this study an enzyme-linked immunosorbent assay was generated with a detection level sufficiently high to measure SAA concentrations in the culture supernatants of the human monocytic leukaemia cell line THP-1. |
Human | S100A9 | 6280 | S100 calcium binding protein A9 | Transcriptional regulation of the gene for the myeloid calcium binding protein, MRP14, was investigated in human monocytic leukemia cell lines. |
Human | PLSCR1 | 5359 | phospholipid scramblase 1 | These results provide new information on the possible roles of MmTRA1b/phospholipid scramblase and the truncated MmTRA1a in the leukemogenesis and differentiation of monocytic leukemia cells. |
Human | PDGFB | 5155 | platelet-derived growth factor beta polypeptide | In the present study, PDGF-1 and PDGF-2 gene expression was compared in HL-60 cells, human THP-1 monocytic leukemia cells, and human monocytes. |
Human | PDGFA | 5154 | platelet-derived growth factor alpha polypeptide | In the present study, PDGF-1 and PDGF-2 gene expression was compared in HL-60 cells, human THP-1 monocytic leukemia cells, and human monocytes. |
Human | OLR1 | 4973 | oxidized low density lipoprotein (lectin-like) receptor 1 | We investigated the effect of histamine on the expression of LOX-1 in cells of the human monocytic leukemia cell line THP-1. Inhibition of NO synthesis in PMA-primed human monocytic leukemia HL-60 cells resulted in a twofold increase in expression of the receptor for oxidized LDL (OxLDL), termed the lectin-like OxLDL receptor (LOX-1). |
Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | These findings are compatible with our previous report that nm23 gene is overexpressed in monocytic leukemia. |
Human | CYTB | 4519 | cytochrome b | In vitro treatment with interferon gamma substantially increases the level of phagocyte cytochrome b heavy chain gene transcripts in normal polymorphonuclear leukocytes, normal monocyte-derived macrophages, and the monocytic leukemia cell line THP-1. |
Human | MLL | 4297 | | t(10;11)(p11.2;q23) involving this and ABI-1 genes is associated with congenital acute monocytic leukemia |
Human | MC1R | 4157 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | Flow cytometry studies showed that melanocortin 1 receptor was expressed in in vitro activated monocytes/macrophages and in the THP-1 monocytic leukaemia line at levels of about 1 in 3 to 1 in 5 of that found in melanomas. |