| Mouse | FGR | 2268 | feline Gardner-Rasheed sarcoma viral oncogene homolog | With an immune complex kinase assay in a monocytic leukemia cell line, 2H2 monoclonal antibody was shown to precipitate a 59-kDa protein that corresponds in molecular mass to murine Fgr. |
| Human | CCL3L3 | 414062 | chemokine (C-C motif) ligand 3-like 3 | This protein was not found in culture supernatants or cell lysates of monocytic leukemia cells and HL-60 cells, although LD78 transcripts were found in those cells. |
| Human | RAB7B | 338382 | RAB7B, member RAS oncogene family | RT-PCR or Western blot analysis of Rab7b expression shows that Rab7b is selectively expressed in monocytes, monocyte-derived immature dendritic cells (DCs), and promyeloid or monocytic leukemia cell lines. |
| Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Treatment of U937 monocytic leukemia cells with rapamycin (10 nmol/L) in conjunction with a minimally toxic concentration of UCN-01 (100 nmol/L) for 36 hours resulted in marked potentiation of mitochondrial injury (i.e., loss of mitochondrial membrane potential and cytosolic release of cytochrome c, AIF, and Smac/DIABLO), caspase activation, and apoptosis. |
| Human | MRAS | 22808 | muscle RAS oncogene homolog | Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras. |
| Human | ABI1 | 10006 | abl-interactor 1 | t(10;11)(p11.2;q23) involving MLL and this gene is associated with congenital acute monocytic leukemia |
| Human | MVP | 9961 | major vault protein | In conclusion, we report that LRP is rather a marker of monocytic lineage than a prognostic index for MDR and we suggest that detection of LRP by ICC could be an argument for the diagnosis of monoblastic and monocytic leukemias. |
| Human | CD83 | 9308 | CD83 molecule | The efficient generation of CD83 positive immunocompetent dendritic cells from CD14 positive acute myelomonocytic or monocytic leukemia cells in vitro. |
| Human | AIFM1 | 9131 | apoptosis-inducing factor, mitochondrion-associated, 1 | Treatment of U937 monocytic leukemia cells with rapamycin (10 nmol/L) in conjunction with a minimally toxic concentration of UCN-01 (100 nmol/L) for 36 hours resulted in marked potentiation of mitochondrial injury (i.e., loss of mitochondrial membrane potential and cytosolic release of cytochrome c, AIF, and Smac/DIABLO), caspase activation, and apoptosis. |
| Human | MLLT10 | 8028 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | Monocytic leukemia with CALM/AF10 rearrangement showing mediastinal emphysema. Monocytic leukemias with CALM/AF10 fusion are frequently associated with mediastinal invasion. |
| Human | MYST3 | 7994 | | We show that a zebrafish ortholog of the human oncogenic histone acetyltransferase MOZ (monocytic leukemia zinc finger) is required for specifying segmental identity in the second through fourth pharyngeal arches. In addition, fluorescence in situ hybridization analysis suggested a rearrangement in the monocytic leukemia zinc finger (MOZ) gene, located in the 8p11 region of chromosome 8. |
| Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | resistance of acute monocytic leukemia cells to calcitriol-induced differentiation correlates with impaired nuclear localization of vitamin D receptor, but not with its total expression in the cells |
| Human | TXN | 7295 | thioredoxin | We therefore investigated the expression of redox-regulating proteins such as glutaredoxin (GRX) and thioredoxin (TRX) during the differentiation of murine monocytic leukemia cell line M1 cells and human monocytic leukemia cell line U937 cells. |
| Human | CCL3L1 | 6349 | chemokine (C-C motif) ligand 3-like 1 | This protein was not found in culture supernatants or cell lysates of monocytic leukemia cells and HL-60 cells, although LD78 transcripts were found in those cells. |
| Human | SAA1 | 6288 | serum amyloid A1 | Because SAA synthesis at the protein level in such cells has never been analyzed quantitatively, in this study an enzyme-linked immunosorbent assay was generated with a detection level sufficiently high to measure SAA concentrations in the culture supernatants of the human monocytic leukaemia cell line THP-1. |
| Human | SAA@ | 6287 | serum amyloid A1 cluster | Because SAA synthesis at the protein level in such cells has never been analyzed quantitatively, in this study an enzyme-linked immunosorbent assay was generated with a detection level sufficiently high to measure SAA concentrations in the culture supernatants of the human monocytic leukaemia cell line THP-1. |
| Human | S100A9 | 6280 | S100 calcium binding protein A9 | Transcriptional regulation of the gene for the myeloid calcium binding protein, MRP14, was investigated in human monocytic leukemia cell lines. |
| Human | PLSCR1 | 5359 | phospholipid scramblase 1 | These results provide new information on the possible roles of MmTRA1b/phospholipid scramblase and the truncated MmTRA1a in the leukemogenesis and differentiation of monocytic leukemia cells. |
| Human | PDGFB | 5155 | platelet-derived growth factor beta polypeptide | In the present study, PDGF-1 and PDGF-2 gene expression was compared in HL-60 cells, human THP-1 monocytic leukemia cells, and human monocytes. |
| Human | PDGFA | 5154 | platelet-derived growth factor alpha polypeptide | In the present study, PDGF-1 and PDGF-2 gene expression was compared in HL-60 cells, human THP-1 monocytic leukemia cells, and human monocytes. |
| Human | OLR1 | 4973 | oxidized low density lipoprotein (lectin-like) receptor 1 | We investigated the effect of histamine on the expression of LOX-1 in cells of the human monocytic leukemia cell line THP-1. Inhibition of NO synthesis in PMA-primed human monocytic leukemia HL-60 cells resulted in a twofold increase in expression of the receptor for oxidized LDL (OxLDL), termed the lectin-like OxLDL receptor (LOX-1). |
| Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | These findings are compatible with our previous report that nm23 gene is overexpressed in monocytic leukemia. |
| Human | CYTB | 4519 | cytochrome b | In vitro treatment with interferon gamma substantially increases the level of phagocyte cytochrome b heavy chain gene transcripts in normal polymorphonuclear leukocytes, normal monocyte-derived macrophages, and the monocytic leukemia cell line THP-1. |
| Human | MLL | 4297 | | t(10;11)(p11.2;q23) involving this and ABI-1 genes is associated with congenital acute monocytic leukemia |
| Human | MC1R | 4157 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | Flow cytometry studies showed that melanocortin 1 receptor was expressed in in vitro activated monocytes/macrophages and in the THP-1 monocytic leukaemia line at levels of about 1 in 3 to 1 in 5 of that found in melanomas. |