Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Rduction in serum adiponectin level is associated with the prevalence and magnitude of systemic atherosclerosis including arteriosclerosis obliterans and ischemic heart disease |
Human | ZNF202 | 7753 | zinc finger protein 202 | This is the first study to suggest that ZNF202 could be a new candidate gene for ischemic heart disease and myocardial infarction in the general population |
Human | TTN | 7273 | titin | expression of titin isoforms switch in ischemic human heart disease |
Human | TNF | 7124 | tumor necrosis factor | Study results suggest that the G-308A polymorphism is unlikely to be associated with the development of ischemic heart disease, whereas it might be a protective factor for ischemic stroke in Asians only |
Human | SOD3 | 6649 | superoxide dismutase 3, extracellular | A common gene variant in the heparin-binding domain of ecSOD, which is a risk factor for ischemic heart disease, may be a risk factor for vascular maladaptation and endothelial dysfunction in heart failure |
Human | ATXN1 | 6310 | ataxin 1 | Sca-1(+)/CD31(-) cells may hold therapeutic possibilities with regard to the treatment of ischemic heart disease |
Human | NPR1 | 4881 | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) | NPR-A protein localized to cardiomyocytes, endocardial endothelial cells, and smooth muscle of intramyocardial vessels; downregulation in the density of NPR-A in heart and coronary was observed in artery of patients with ischemic heart disease |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | The GluAsp or AspAsp genotype of the Glu298Asp polymorphism is significantly associated with ischemic heart disease, but not albuminuria in Japanese diabetic subjects |
Human | MMP3 | 4314 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | in an Irish population, the MMP-3 -1612 5A/6A polymorphism is not associated with ischaemic heart disease |
Human | LPL | 4023 | lipoprotein lipase | The S447X mutation is associated with anti-atherogenic effects on TG and HDL cholesterol in both genders, and with a moderate protective effect on risk of ischemic heart disease in men |
Human | KIT | 3815 | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | c-Kit positive cardiosphere-forming cells were isolated from biopsy samples from patients with ischemic heart disease |
Human | IGFBP1 | 3484 | insulin-like growth factor binding protein 1 | low baseline levels of insulin-like growth factor-I and insulin-like growth factor binding protein-1 increase the risk of fatal ischemic heart disease among elderly men and women independent of prevalent risk factors |
Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | low baseline levels of insulin-like growth factor-I and insulin-like growth factor binding protein-1 increase the risk of fatal ischemic heart disease among elderly men and women independent of prevalent risk factors |
Human | HMOX1 | 3162 | heme oxygenase (decycling) 1 | The AA genotype of HMOX1 reduced the incidence of ischemic heart disease, possibly due to the expression level of HMOX1 |
Human | HLA-DRB1 | 3123 | | The risk of mortality due to ischemic heart disease or cancer in rheumatoid arthritis is increased in patients carrying HLA-DRB1 genotypes with particular homozygous and compound heterozygous SE combinations |
Human | HFE | 3077 | hemochromatosis | S65C allele may contribute to the development of CM, but that these three HFE mutations do not appear to play a significant role in development of ischemic heart disease |
Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | evaluation of Factor V Leiden as a risk factor for myocardial infarction, ischemic stroke, or non-MI ischemic heart disease |
Human | ESR1 | 2099 | estrogen receptor 1 | Postmenopausal women who carry ESR1 haplotype 1 (c.454-397 T allele and c.454-351 A allele) have an increased risk of myocardial infarction and ischemic heart disease, independent of known cardiovascular risk factors |
Human | EDNRB | 1910 | endothelin receptor type B | Endothelin ETB receptor mRNA levels are significantly higher in arteries from patients with ischemic heart disease as compared to congestive heart failure and controls |
Human | EDNRA | 1909 | endothelin receptor type A | Endothelin ETA receptor mRNA levels are significantly higher in arteries from patients with ischemic heart disease as compared to congestive heart failure and controls |
Human | APOE | 348 | apolipoprotein E | The APOE epsilon2 allele was in linkage disequilibrium with the -427C allele in atherosclerosis diseases, and the -219T allele was associated with the epsilon4 allele in the ischemia heart disease group found a significant increase in the hazard of ischemic heart disease in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other risk factors, and structural isoform variations of the ApoE |
Human | APOB | 338 | apolipoprotein B | data suggest that the relationship between apoB levels, hypercholesterolemia and ischemic heart disease risk cannot have a simple molecular basis in the apoB gene |
Human | APOA1 | 335 | apolipoprotein A-I | Apolipoprotein(a) 14-15 pentanucleotide repeats predict elevated levels of lipoprotein(a) and a 3- and 2-fold increased risk of myocardial infarction and ischemic heart disease in the general population |
Human | AGER | 177 | advanced glycosylation end product-specific receptor | results show that the -374A allele (-374T>A polymorphism) in the RAGE gene is related to the susceptibility of developing ischemic heart disease in African-Brazilians with type 2 diabetes |
Human | ABCA1 | 19 | ATP-binding cassette, sub-family A (ABC1), member 1 | 3 of 6 nonsynonymous single nucleotide polymorphisms in ATP-binding cassette sub-family A (ABC1) member 1 (ABCA1) predict risk of ischemic heart disease in the general population |