Genes (27)
Species: human : 27 | |
Human | TSGA10 | 80705 | testis specific, 10 | Conclusions TSGA10 is a new tumour-associated antigen of cutaneous lymphoma. By reverse transcription-polymerase chain reaction analysis, TSGA10 was found expressed in all cutaneous lymphoma samples tested, various tumour cell lines, testis, peripheral blood mononuclear cells, skin, isolated lymphocytes, keratinocytes and fibroblasts. | Human | LILRB1 | 10859 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte immunoglobulin-like receptor (LIR-1). | Human | MVP | 9961 | major vault protein | PURPOSE: We have studied whether cutaneous lymphomas express the following multidrug resistance (MDR) related proteins: multidrug resistance protein (MRP), lung resistance protein (LRP) and P-glycoprotein (Pgp). | Human | TNFRSF4 | 7293 | tumor necrosis factor receptor superfamily, member 4 | CD30 has been used for the immunophenotyping and subclassification of cutaneous lymphomas; virtually nothing is known, however, about the expression pattern of CD134 in lymphoid skin malignancies. OBJECTIVES: To determine CD134 expression in cutaneous lymphoma and benign inflammatory disorders.METHODS: Biopsy material was obtained from patients with lymphomatoid papulosis (LyP, n = 42), mycosis fungoides (n = 21), Jessner;s infiltrates (n = 10) and non-specific dermatitis (n = 14). | Human | TFRC | 7037 | transferrin receptor (p90, CD71) | In cutaneous lymphomas of high grade malignancy the TFR was expressed in virtually all cells compared to only 25-75% in low grade lymphomas. | Human | TRG@ | 6965 | | A clonal TCRG gene rearrangement was detected in 7 skin samples, corresponding to a maculopapular eruption with a histological pattern of nonspecific mild lymphoid dermal infiltrate in 6 patients, and to erythematous plaques with histological findings of typical cutaneous lymphoma in 1 patient. | Human | S100A9 | 6280 | S100 calcium binding protein A9 | Three T cell-associated markers (UCHL1, MT-1, MT-2, six B cell-associated markers (MB-1, MB-2, LN-1, LN-2, L-26, 4KB5), immunoglobulin heavy and light chains, anti-LCA antibody, two markers for Reed-Sternberg cells (Ber-H2, Leu-M1), one marker for macrophages (Mac-387) and anti-S-100 protein antibody were tested on normal skin, inflammatory skin diseases, and cutaneous lymphomas and pseudolymphomas. | Human | NFKB2 | 4791 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | In particular, the NFKB2 gene, localized on chromosome 10q24, represents a candidate proto-oncogene, since it has been found rearranged in certain types of lymphoma and more commonly in cutaneous lymphoma. bcl-1, bcl-2, p53, c-myc, and lyt-10 analysis in cutaneous lymphomas. Rearrangements of the NFKB-2 locus leading to the production of 3; truncated NFKB-2 proteins are recurrently found in lymphoid neoplasms, particularly cutaneous lymphomas. In the present study we investigated the pathogenetic role of c-myc, bcl-2, and lyt-10 oncogenes, bcl-1 locus, and p53 suppressor gene in a representative panel of cutaneous lymphomas, including 25 cases of cutaneous B cell lymphoma (CBCL) and 29 cases of cutaneous T cell lymphoma (CTCL). | Human | MT1L | 4500 | metallothionein 1L (gene/pseudogene) | Three T cell-associated markers (UCHL1, MT-1, MT-2, six B cell-associated markers (MB-1, MB-2, LN-1, LN-2, L-26, 4KB5), immunoglobulin heavy and light chains, anti-LCA antibody, two markers for Reed-Sternberg cells (Ber-H2, Leu-M1), one marker for macrophages (Mac-387) and anti-S-100 protein antibody were tested on normal skin, inflammatory skin diseases, and cutaneous lymphomas and pseudolymphomas. | Human | MT1H | 4496 | metallothionein 1H | Three T cell-associated markers (UCHL1, MT-1, MT-2, six B cell-associated markers (MB-1, MB-2, LN-1, LN-2, L-26, 4KB5), immunoglobulin heavy and light chains, anti-LCA antibody, two markers for Reed-Sternberg cells (Ber-H2, Leu-M1), one marker for macrophages (Mac-387) and anti-S-100 protein antibody were tested on normal skin, inflammatory skin diseases, and cutaneous lymphomas and pseudolymphomas. | Human | MIF | 4282 | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | Macrophage migration inhibitor factor (MIF) activity in the sera of patients with mycosis fungoides, Sezary syndrome, and cutaneous lymphoma was observed in the sera of eight of the ten patients with stage II (infiltrative) mycosis fungoides, but in only one of the eight patients with stage I and in neither of the two patients with stage III mycosis fungoides. No MIF was observed in cutaneous lymphoma. | Human | LGALS1 | 3956 | lectin, galactoside-binding, soluble, 1 | Galectin fingerprinting by immuno- and lectin histochemistry in cutaneous lymphoma. | Human | KLRD1 | 3824 | killer cell lectin-like receptor subfamily D, member 1 | Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte immunoglobulin-like receptor (LIR-1). | Human | KLRC1 | 3821 | killer cell lectin-like receptor subfamily C, member 1 | Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte immunoglobulin-like receptor (LIR-1). | Human | KIR3DL2 | 3812 | killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 | Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte immunoglobulin-like receptor (LIR-1). | Human | KIR2DL2 | 3803 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 | Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte immunoglobulin-like receptor (LIR-1). | Human | KIR2DL1 | 3802 | killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 | Frozen sections from four CD8+ and from three CD56+ cutaneous lymphomas were stained for the cytotoxicity markers including T-cell restricted intracellular antigen-1, perforin, granzyme B, and for expression of the inhibitory receptors including p58.1, p58.2, p70, p140, CD94, NKG2, and leukocyte immunoglobulin-like receptor (LIR-1). | Human | JUNB | 3726 | jun B proto-oncogene | BCL2 and JUNB abnormalities in primary cutaneous lymphomas. results have revealed, for the first time, amplification and expression patterns of JUNB in primary cutaneous lymphomas OBJECTIVES: To investigate genomic and protein expression status of BCL2 and to compare the results with that of JUNB in primary cutaneous lymphomas (PCLs). | Human | IL10 | 3586 | interleukin 10 | HLA-G and IL-10 may play roles in the evasion of immunosurveillance in cutaneous lymphomas | Human | ICAM3 | 3385 | intercellular adhesion molecule 3 | ICAM-3 was found to be expressed by epidermal CD1a+ Langerhans cells, by cells of Langerhans cell histiocytosis, by T and B lymphocytes infiltrating the dermis in cutaneous lymphomas and in a wide spectrum of inflammatory dermatoses. The findings suggest that ICAM-3 expression may be induced on endothelial cells in late-stage cutaneous lymphomas, probably by a cytokine-mediated mechanism. Expression of intercellular adhesion molecule 3 (CDw50) on endothelial cells in cutaneous lymphomas. The endothelial cells in skin biopsies of seven of 30 primary cutaneous lymphomas expressed ICAM-3. | Human | HOXC6 | 3223 | homeobox C6 | In the present study the expression of HOXC4, HOXC5, and HOXC6 in primary cutaneous lymphomas was investigated. Using RNA in situ hybridization (RISH) and semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR), we found strong expression of HOXC4 and HOXC6 in all, except one, primary cutaneous lymphomas and all reactive cutaneous lymphoid infiltrates. | Human | HOXC5 | 3222 | homeobox C5 | As a strong expression of HOXC5 in primary cutaneous lymphomas was observed only in anaplastic large T-cell lymphomas and reactive control tissues lacked HOXC5 expression, these data strongly support a role for HOXC5 in the genesis of anaplastic large-T-cell lymphomas. In the present study the expression of HOXC4, HOXC5, and HOXC6 in primary cutaneous lymphomas was investigated. | Human | HOXC4 | 3221 | homeobox C4 | In the present study the expression of HOXC4, HOXC5, and HOXC6 in primary cutaneous lymphomas was investigated. Using RNA in situ hybridization (RISH) and semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR), we found strong expression of HOXC4 and HOXC6 in all, except one, primary cutaneous lymphomas and all reactive cutaneous lymphoid infiltrates. | Human | HLA-G | 3135 | | HLA-G protein up-regulation in primary cutaneous lymphomas is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas. HLA-G and IL-10 may play roles in the evasion of immunosurveillance in cutaneous lymphomas | Human | TNFSF8 | 944 | tumor necrosis factor (ligand) superfamily, member 8 | In particular, CD30L (over)expression might have a major role in the mechanism of self-regression of skin lesions, the most distinctive clinical feature of this cutaneous lymphoma subtype. |
|