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Genes (102)
Species: human : 100 mouse : 2 | |
Mouse | PPARD | 5467 | peroxisome proliferator-activated receptor delta | Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. | Mouse | CCKBR | 887 | cholecystokinin B receptor | Some colorectal adenomas express cholecystokinin B/gastrin receptor mRNA, and thus hypergastrinemia may increase progression through the adenoma-carcinoma sequence. | Human | ENPP7 | 339221 | ectonucleotide pyrophosphatase/phosphodiesterase 7 | We recently found that both human colorectal adenomas and carcinomas were associated with a specific decrease in alkaline sphingomyelinase activity. | Human | CRAC1 | 338377 | colorectal adenoma and carcinoma 1 | A susceptibility gene to colorectal adenomas and carcinoma (CRAC1) on chromosome region 15q14 approximately q22 has been proposed on the basis of linkage in a single family. Although there are probably multiple causes of the multiple colorectal adenoma and cancer phenotype in Ashkenazim, an important one is the HMPS/CRAC1 locus on 15q13-q14. Since this region encompassed CRAC1, a locus involved in inherited susceptibility to colorectal adenomas and carcinomas in another Ashkenazi family (SM1311), we determined whether HMPS and CRAC1 might be the same. Using genetic linkage analysis, supplemented by allele loss in tumors, we have provided evidence for a new colorectal cancer susceptibility gene, CRAC1 (colorectal adenoma and carcinoma), mapping to chromosome 15q14-q22. | Human | NEIL2 | 252969 | nei endonuclease VIII-like 2 (E. coli) | We used dHPLC to identify germline variants in MSH6, NEIL2, NEIL3, and OGG1 in 172 patients with multiple colorectal adenomas. | Human | REG4 | 83998 | regenerating islet-derived family, member 4 | Click here to display 8 evidence detail records. | Human | CHFR | 55743 | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | We found CpG methylation-dependent silencing of CHFR expression in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers. | Human | UGT1A6 | 54578 | UDP glucuronosyltransferase 1 family, polypeptide A6 | To determine whether polymorphisms in the UGT1A6 enzyme modulate the protective benefit of regular aspirin use on colorectal adenoma, we conducted a prospective, nested case-control study of 1062 women who provided blood specimens and detailed data on aspirin use before undergoing lower endoscopy. Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. | Human | RRM2B | 50484 | ribonucleotide reductase M2 B (TP53 inducible) | Additionally, we determined the frequency of these p53R2 variants in a recently concluded case-control study of incident sporadic colorectal adenomas (163 cases and 210 controls). Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls. | Human | BACE2 | 25825 | beta-site APP-cleaving enzyme 2 | CONCLUSION: ALP56 may contribute to colorectal adenoma formation and to an exophytic growth pattern in these adenomas. A novel aspartate protease gene, ALP56, is related to morphological features of colorectal adenomas. | Human | TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | The HPP1 gene was initially discovered because of its frequent hypermethylation in hyperplastic colon polyps, but it is also hypermethylated in colorectal adenomas and carcinomas. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | Variants in AMACR associated with advanced distal colorectal adenoma were identified and pointed to potential interactions with iburpofen use | Human | CHEK2 | 11200 | checkpoint kinase 2 | To further our knowledge about the contribution of CHEK2 1100delC to cancer incidence we have analysed a series of 149 patients with multiple colorectal adenomas some of whom developed colorectal cancer. Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma. | Human | TREH | 11181 | trehalase (brush-border membrane glycoprotein) | Sucrase-isomaltase (SI), trehalase (T) and lactase-beta-glucosidase (LG) activities were assessed histochemically in samples of colorectal adenomas (11 tubular, 12 tubulovillous, 10 villous) and 30 adenocarcinomas obtained by biopsy during colonoscopy or from specimens removed by surgical intervention. | Human | HSPH1 | 10808 | heat shock 105kDa/110kDa protein 1 | The 44 of 53 patients with colorectal cancers (83.0%) and only 2 of 21 (9.5%) with colorectal adenomas had an evident overexpression of hsp105, which means that overexpression of hsp105 is a late event in the colorectal adenoma-carcinoma sequence. | Human | SLC23A1 | 9963 | solute carrier family 23 (ascorbic acid transporter), member 1 | The analysis of common single nucleotide polymorphisms in SLC23A1 revealed no association with colorectal adenoma risk | Human | SLC23A2 | 9962 | solute carrier family 23 (ascorbic acid transporter), member 2 | For SLC23A2, overall, there was no colorectal adenoma association with haplotypes, but two SNPs located in intron 8 and exon 11 could be associated (odds ratio = 0.49, 95% confidence interval = 0.25-0.95 for haplotype G-C vs. haplotype C-C) | Human | RASSF2 | 9770 | Ras association (RalGDS/AF-6) domain family member 2 | RASSF2 methylation was also frequently identified in colorectal adenomas. | Human | PTGES | 9536 | prostaglandin E synthase | Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer. | Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | High expression of beta-catenin and securin (hPTTG1) in colorectal adenomas and carcinomas; securin is a target of beta-catenin transcriptional activation | Human | TNFSF10 | 8743 | tumor necrosis factor (ligand) superfamily, member 10 | TRAIL has a role in inducing apoptosis in human colorectal adenoma | Human | PLA2G6 | 8398 | phospholipase A2, group VI (cytosolic, calcium-independent) | Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. | Human | XRCC3 | 7517 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC1 and XRCC3 Polymorphisms and Their Role as Effect Modifiers of Unsaturated Fatty Acids and Antioxidant Intake on Colorectal Adenomas Risk. Finds no association between XRCC3 T241M and two intronic XRCC3 polymorphisms and risk of colorectal adenoma XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma. Using a large sigmoidoscopy-based case-control study (753 cases and 799 controls) in Los Angeles County, we investigated possible associations between single-nucleotide polymorphisms in the XRCC1 (codons 194 Arg/Trp and codon 399 Arg/Gln) and XRCC3 (codon 241 Thr/Met) genes and colorectal adenoma risk and their possible role as modifiers of the effect of monounsaturated fatty acid, the ratio of omega-6/omega-3 polyunsaturated fatty acids, and antioxidant intake. | Human | XRCC2 | 7516 | X-ray repair complementing defective repair in Chinese hamster cells 2 | Finds no association between XRCC2 R188H polymorphism and risk of colorectal adenoma XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma. | Human | XPC | 7508 | xeroderma pigmentosum, complementation group C | Three linked XPC alleles, 492R, 499A, and 939Q, were associated with increased risk of colorectal adenoma in smokers |
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