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Genes (55)
Species:
human : 55 | |
| Human | DAOA | 267012 | D-amino acid oxidase activator | This is the first study to the authors' knowledge to implicate the G72 locus in the etiology of major depression and neuroticism | | Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Salivary serotonin in patients with major depressive disorder showed clear circadian rhythm [serotonin] | | Human | C5orf20 | 140947 | chromosome 5 open reading frame 20 | Marker rs12520799, in dendritic cell nuclear protein 1 on chromosome 5, yielded a significant association with lifetime major depression | | Human | TPH2 | 121278 | tryptophan hydroxylase 2 | our results do not confirm the role of the R441H mutation of the hTPH2 gene in the susceptibility to unipolar major depression Single nucleotide polymorphisms were discovered through a systematic characterization of the genetic architecture of the TPH2 gene in major depression Identification of a loss-of-function mutation in hTPH2 suggests that defect in brain serotonin synthesis may represent an important risk factor for unipolar major depression | | Human | GMIP | 51291 | GEM interacting protein | Variations in the GMIP gene can confer susceptibility to major depressive disorder | | Human | DISC1 | 27185 | disrupted in schizophrenia 1 | Study found that Cys704 allele of the Ser704Cys single-nucleotide polymorphism (SNP) was associated with an increased risk of developing major depressive disorder and strong evidence for association in a multi-marker haplotype analysis with this SNP | | Human | MED12 | 9968 | mediator complex subunit 12 | Title:The association of a HOPA polymorphism with major depression and phobia.|Association:Y|Conclusion:We conclude that HOPA polymorphisms may be a moderate risk factor for increased susceptibility to a broad spectrum of neuropsychiatric illness and hypothesize that the type of illness manifested might be related to a separate genetic diathesis. | | Human | HTR3B | 9177 | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic | an HTR3B variant associated with major depression dramatically augments the signaling of the human 5-HT3AB receptor | | Human | ARTN | 9048 | artemin | Data show that reduced expression levels of ARTN mRNAs are found in patients with major depressive disorder in a current depressive state, but not in a remissive state | | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | A218C polymorphism of the TPH gene does not play a major role in pathogenesis in major depressive disorder and does not serve as a modulator of antidepressant activity The result suggests that 218A/C variants of TPH1 cannot play a major role as predictor of treatment response as well as intolerance in Japanese patients with major depression te most common TPH-1 variants appear to carry no risk, while some of the less frequent variants might contribute to genetic predisposition to major depression | | Human | TNF | 7124 | tumor necrosis factor | -G308A tumour necrosis factor-alpha gene polymorphism may have a potential role for susceptibility to major depressive disorder in the Korean population | | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Click here to display 14 evidence detail records. | | Human | SLC6A2 | 6530 | solute carrier family 6 (neurotransmitter transporter), member 2 | study suggests that the investigated polymorphisms in the NET gene are not major risk factors in increasing susceptibility to either major depression or its clinical subtypes in a Han Chinese population The norepinephrine transporter T-182C polymorphism may be in part related to the pathophysiology of major depressive disorder in a Japanese population norepinephrine transporter polymorphism appears not to be an important factor in susceptibility to major depressive disorder in a Japanese population norepinephrine transporter polymorphisms are not major susceptibility factors in the etiology of major depression This result suggests that the T-182C polymorphism in the NET gene might be associated with major depression | | Human | S100A10 | 6281 | S100 calcium binding protein A10 | Single nucleotide polymorphisms in S100A10 gene is not associated with major depressive disorder | | Human | ABCB1 | 5243 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | MDR1 variants G2677T and C3435T are not associated with therapeutic response to paroxetine in patients with major depression Title:A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression.|Association:Y|Conclusion:Our results suggest that homozygosity for 3435T alleles of ABCB1 is a risk factor for occurrence of nortriptyline-induced postural hypotension (OR = 1.37, P = 0.042, 95% CI 1.01-1.86). | | Human | PDE4A | 5141 | phosphodiesterase 4A, cAMP-specific | observed that specific isoforms of PDE4A were reduced in cerebella of patients with bipolar disorder, whereas there was no change in patients with schizophrenia or major depression | | Human | PAWR | 5074 | PRKC, apoptosis, WT1, regulator | No significant genetic association was found with schizophrenia or Major Depressive Disorder or Bipolar Disorder | | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | SERPINE1 genetic variants may play a role in major depressive disorder susceptibility and in the acute therapeutic response to selective serotonin reuptake inhibitors | | Human | NTF3 | 4908 | neurotrophin 3 | Data show that reduced expression levels of NT-3 mRNAs are found in patients with major depressive disorder in a current depressive state, but not in a remissive state | | Human | MAOB | 4129 | monoamine oxidase B | MAOB A644G single nucleotide polymorphism is involved in the outcome of treatment with mirtazapine or paroxetine in females with major depression | | Human | MAOA | 4128 | monoamine oxidase A | The study suggest gender-specific contribution of the more active MAO-A VNTR variant to an increased vulnerability for complicated grief as a potential intermediate phenotype of major depression Investigation of possible ssociation of a T941G single nucleotide polymorphism with generalized anxiety disorder, panic disorder, or major depression showed an association with gneralized anxiety disorder only These data suggest that the EcoRV and uVNTR polymorphisms may be involved in the pathogenesis of major depression and associated with insomnia in depressed patients Title:Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder.|Association:Y|Conclusion:Thus, our data suggest that an excess of high-activity MAO-A gene promoter alleles resulting in an elevated MAO-A activity is a risk factor for major depressive disorder in females. This study findings suggest that the MAOA-uVNTR may be involved in the pathogenesis of major depressive disorder and the antidepressant therapeutic mechanisms in Chinese population, and that there may be a gender effect in this association Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression | | Human | LEP | 3952 | leptin | mRNA expresion in brain was significantly reduced in major depressive disorders and suicide | | Human | L1CAM | 3897 | L1 cell adhesion molecule | Levels of CAM-L1 were increased in the prefrontal cortex of the major depression | | Human | IL10 | 3586 | interleukin 10 | polymorphism at position -819 does not confer susceptibility to major depression and schizophrenia in Korean study population | | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | elevated spontaneous production of IL-6 in patients with major depression |
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