| Human | AMIGO2 | 347902 | adhesion molecule with Ig-like domain 2 | Stable expression of a DEGA/AMIGO-2 antisense construct led to altered morphology, increased ploidy, chromosomal instability, decreased cell adhesion/migration, and a nearly complete abrogation of tumorigenicity in nude mice |
| Human | SGOL1 | 151648 | shugoshin-like 1 (S. pombe) | findings suggest that hSgo1-downregulated colorectal cancers have a clinicopathological character of chromosome instability (CIN), and hSgo1 downregulation leads to CIN in colorectal cancer cells |
| Human | SPINK7 | 84651 | serine peptidase inhibitor, Kazal type 7 (putative) | ECRG2 is important for ensuring centrosome duplication, spindle assembly checkpoint, and accurate chromosome segregation, and its depletion may contribute to chromosome instability and aneuploidy in human cancers |
| Human | MUS81 | 80198 | MUS81 structure-specific endonuclease subunit | Data suggest that Mus81 suppresses chromosomal instability by converting potentially detrimental replication-associated DNA structures into intermediates that are more amenable to DNA repair |
| Human | RNF20 | 56254 | ring finger protein 20, E3 ubiquitin protein ligase | identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells |
| Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | genetic inactivation of hCDC4, by means of targeted disruption of the gene in karyotypically stable colorectal cancer cells, results in a striking phenotype associated with micronuclei and chromosomal instability |
| Human | TINF2 | 26277 | TERF1 (TRF1)-interacting nuclear factor 2 | Chromosome instability (hypo-/hyperdiploidy, chromosomal breaks, premature centromere division) |
| Human | POT1 | 25913 | protection of telomeres 1 | Pot1 protects chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation The reduction of POT1 by RNA interference led to the loss of telomeric single-stranded overhangs and induced apoptosis, chromosomal instability, and senescence in cells |
| Human | NIPBL | 25836 | Nipped-B homolog (Drosophila) | identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells |
| Human | BOP1 | 23246 | block of proliferation 1 | Deregulation of the BOP1 pathway contributes to chromosomal instability in colorectal tumorigenesis |
| Human | WAPAL | 23063 | wings apart-like homolog (Drosophila) | our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability |
| Human | CHEK2 | 11200 | checkpoint kinase 2 | CHK2-depleted cells do not exhibit chromosome instability or common fragile site breaks |
| Human | STAG3 | 10734 | stromal antigen 3 | identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells |
| Human | UBD | 10537 | ubiquitin D | high levels of FAT10 protein in cells lead to increased mitotic nondisjunction and chromosome instability, which is mediated by an abbreviated mitotic phase and reduction in the kinetochore localization of MAD2 during prometaphase |
| Human | PTTG1 | 9232 | pituitary tumor-transforming 1 | Overexpression of gamma-catenin caused an increase in PTTG and c-Myc protein levels, which are likely to accelerate chromosomal instability and uncontrolled proliferation, respectively, in the affected cells |
| Human | SMC3 | 9126 | structural maintenance of chromosomes 3 | identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells |
| Human | MTA1 | 9112 | metastasis associated 1 | These findings strongly implicate MTA1 in the transcriptional repression of BRCA1 leading to abnormal centrosome number and chromosomal instability |
| Human | SMC1A | 8243 | structural maintenance of chromosomes 1A | identified as one of five genes containing 11 somatic mutations in a panel that included 132 colorectal cancers, then demonstrated that down-regulation of such homologs resulted in chromosomal instability and chromatid cohesion defects in human cells |
| Human | XRCC5 | 7520 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | HCT116 cells heterozygous for deficiency have high rates of chromosomal instability |
| Human | WRN | 7486 | Werner syndrome, RecQ helicase-like | These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs |
| Human | TWIST1 | 7291 | twist basic helix-loop-helix transcription factor 1 | Twist overexpression plays a role in destabilizing the genome, thus promoting chromosomal instability |
| Human | TP53 | 7157 | tumor protein p53 | incidence of additional cytogenetic abnormalities, reflecting an increased chromosomal instability, was higher in >or=5%TP53-deleted cases KRAS and p53 gene mutations, which are rarely simultaneous and are associated with specific DI aneuploid values, do not represent a synergistic evolutionary pathway but may influence mechanisms of chromosomal instability Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure |
| Human | AURKA | 6790 | aurora kinase A | Overexpression of STK15 gene in laryngeal carcinoma was discovered the first time, it may caused chromosomal instability through abnormal centrosome, therefore having some effect during the occurrence and development of laryngeal carcinoma AURKA amplification contributes to pancreatic carcinogenesis by increasing chromosome instability and centrosome abnormality |
| Human | SMARCB1 | 6598 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | hSNF5 activates the mitotic checkpoint through the p16INK4a-cyclinD/CDK4-pRb-E2F pathway, whereas loss of hSNF5 function in malignant rhabdoid tumor-derived cells leads to polyploidization and chromosomal instability |
| Human | PRKDC | 5591 | protein kinase, DNA-activated, catalytic polypeptide | Lower DNA-PK activity correlated with higher chromosome instability and lymph node metastasis in breast cancer |
