| Human | LOC100507436 | 100507436 | | MICA-NKG2D interaction constitutes a mechanism by which monocytes and NK cells as an early source of IFN-gamma may communicate directly during an innate immune response to infections in humans |
| Human | MIR146A | 406938 | microRNA 146a | studies indicate that rapid increase in miRNA-146a expression provides a novel mechanism for the negative regulation of severe inflammation during the innate immune response |
| Human | IL29 | 282618 | | Study shows that IFNL1, a cytokine produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and may be important in activating innate immune responses at the site of viral infection |
| Human | CASP12 | 120329 | caspase 12 (gene/pseudogene) | Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis |
| Human | PGLYRP2 | 114770 | peptidoglycan recognition protein 2 | pglyrp2 expression in skin and liver is important for systemic and local innate immune responses to bacterial infections |
| Human | TREML2 | 79865 | triggering receptor expressed on myeloid cells-like 2 | TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation |
| Human | NLRX1 | 79671 | NLR family member X1 | These results identify NLRX1 as a NLR that contributes to the link between reactive oxygen species generation at the mitochondria and innate immune responses |
| Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | Altered mechanisms regulating NOD2 induction, NF-kappaB activation and cytokine production may contribute to dysregulate the innate immune response underlying pediatric CD CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses in innate immune responses to invading microbes, a combination of signaling through TLRs and NOD1/2 leads to the synergistic activation of antibacterial responses in the oral epithelium |
| Human | MAVS | 57506 | mitochondrial antiviral signaling protein | PKR facilitates the host innate immune response and apoptosis in virus-infected cells by mediating IRF-3 activation through the mitochondrial IPS-1 signal transduction pathway |
| Human | SELS | 55829 | | Positive relationship between Tanis mRNA and the acute-phase protein serum amyloid A suggests an interaction between innate immune system responses and Tanis expression in muscle and adipose tissue |
| Human | OTUD5 | 55593 | OTU domain containing 5 | data identify DUBA as a negative regulator of innate immune responses |
| Human | TLR9 | 54106 | toll-like receptor 9 | TLR3 and 9 as well as IFN-beta and TNF-alpha are expressed in verruca and molluscum contagiosum skin lesions and may play a pivotal role in cutaneous innate immune responses Broad TLR9 activation defects in common variable immune deficiency prevent CpG-DNA-initiated innate immune responses; these defects may lead to impaired responses of plasmacytoid dendritic cells and loss of B cell function |
| Human | PLUNC | 51297 | | members of the PLUNC family may function in the innate immune response in regions of the mouth, nose and lungs, which are sites of significant bacterial exposure |
| Human | CRNN | 49860 | cornulin | SEP53 may be a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen |
| Human | CD209 | 30835 | CD209 molecule | differentiation of monocytes into CD209(+) macrophages and CD1b(+) dendritic cells distinctly mediate the innate immune response to Propionibacterium acnes |
| Human | TBK1 | 29110 | TANK-binding kinase 1 | IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response |
| Human | DDX58 | 23586 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | JEV and DEN-2 initiate the host innate immune response through a molecular mechanism involving RIG-I/IRF-3 and PI3K/NF-kappaB signaling pathways |
| Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | the NKG2D-of MHC Class I chain-related protein interaction is an important molecular mechanism that is involved in the innate immune response to microbial signals in the human uterine endometr |
| Human | AKAP13 | 11214 | A kinase (PRKA) anchor protein 13 | AKAP13 plays a role in TLR2-mediated NF-kappaB activation; GEF-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs |
| Human | NOD1 | 10392 | nucleotide-binding oligomerization domain containing 1 | CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses |
| Human | TLR6 | 10333 | toll-like receptor 6 | studies reveal coordinated induction of TLR2 and TLR6 during hypoxia and suggest tissue hypoxia in transcriptional adaptation of innate immune responses during acute infection or inflammation |
| Human | ACAP1 | 9744 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | CENTB1 selectively down-regulates NF-kappaB activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses |
| Human | SOCS3 | 9021 | suppressor of cytokine signaling 3 | SOCS3 and SOCS1 critically regulate influenza A virus-triggered innate immune responses by inhibiting type I interferon alphabeta receptor (IFNAR)1 antiviral signaling and differentially modulating inflammatory signaling pathways |
| Human | SOCS1 | 8651 | suppressor of cytokine signaling 1 | The STAT1-SOCS1 pathway regulates the innate immune response via TLR3 signaling in epidermal keratinocytes SOCS1 and SOCS3 critically regulate influenza A virus-triggered innate immune responses by inhibiting type I interferon receptor (IFNAR)1 antiviral signaling and modulating inflammatory signaling pathways |
| Human | TXN | 7295 | thioredoxin | A truncated form of endogenous thioredoxin (Trx80) is an early signal in response to danger which can stimulate CD14+ monocytes to differentiate into a novel cell population that may play a major role in triggering innate immune responses |
