Mouse | PRSS21 | 10942 | protease, serine, 21 (testisin) | Our functional data coupled with the restricted normal tissue distribution of testisin and its overexpression in a majority of ovarian cancers validates this cell surface protein as a target for therapeutic intervention. |
Mouse | GLS | 2744 | glutaminase | In this study the enzyme glutaminase, purified from the ascites fluid of ovarian cancer patients, was analysed for its antiangiogenic activity. |
Mouse | FLT1 | 2321 | fms-related tyrosine kinase 1 | Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer. |
Mouse | DUSP1 | 1843 | dual specificity phosphatase 1 | Induced expression of CL100 in ovarian cancer cells suppressed intraperitoneal tumor growth in nude mice. |
Mouse | GADD45A | 1647 | growth arrest and DNA-damage-inducible, alpha | After the treatment, tumors were excised and processed for histologic examination, Ki-67 staining, and tissue terminal deoxynucleotide transferase-mediated dUTP nick end labeling (TUNEL) assays to evaluate the morphologic, proliferative, and apoptotic changes induced by EB1089, respectively.RESULTS: The study shows that EB1089 suppresses the in vitro growth of ovarian cancer cells and transcriptionally activates the GADD45 reporter gene more effectively than 1,25(OH)(2)D(3). |
Mouse | ANGPT2 | 285 | angiopoietin 2 | In the mouse ovarian cancer model, up-regulation of Ang-2 in host stroma endothelial cells was significantly associated with pericyte loss and instability of the host vasculature surrounding the tumor. |
Human | CD24 | 100133941 | CD24 molecule | is expressed in ovarian cancer and is a new independent prognostic marker of patient survival Study identifies CD24 and EpCAM as cargo proteins of exosomes of cultured ovarian cancer cell lines and malignant ascites |
Human | MIR146A | 406938 | microRNA 146a | breast/ovarian cancer patients with variant C allele miR-146a may have high levels of mature miR-146 and that these variants predispose them to an earlier age of onset of familial breast and ovarian cancers |
Human | MIRLET7A3 | 406883 | microRNA let-7a-3 | let-7a-3 gene is methylated and the methylation may affect IGF-II expression and the survival of ovarian cancer patients |
Human | BRCA1P1 | 394269 | BRCA1 pseudogene 1 | METHODS: Ovarian cancers from a hospital-based tumor bank were characterized as having a BRCA1 mutation; or a methylated BRCA1, BRCA1 pseudogene or MLH1 promotor; or a wild-type BRCA gene. |
Human | LOC390998 | 390998 | ribosomal protein L10 pseudogene | Loss of heterozygosity and microsatellite instability at the Xq28 and the A/G heterozygosity of the QM gene are associated with ovarian cancer |
Human | PRSS41 | 360226 | protease, serine, 41 | tessp1 protein was detectable in prostate cancer and in some ovarian cancer tissues, indicating tumor-related synthesis of tessp1 beyond testis tissue |
Human | VSIG1 | 340547 | V-set and immunoglobulin domain containing 1 | expressed, both at the mRNA and protein level, in gastric, esophageal, and ovarian cancers, while expression in normal tissues was restricted to testis and stomach |
Human | SNAI3 | 333929 | snail family zinc finger 3 | SNAI3 gene, was located between KIAA0233 gene and CBFA2T3 gene in human chromosome 16q24.3, a region affected in breast cancer, gastric cancer, hepatocellular carcinoma, ovarian cancer, and therapy-related myeloid leukemia with t(16;21)(q24;q22) translocation. |
Human | POTED | 317754 | POTE ankyrin domain family, member D | A survey of several cancer samples showed that POTE was expressed in 6 of 6 prostate, 12 of 13 breast, 5 of 5 colon, 5 of 6 lung, and 4 of 5 ovarian cancers. |
Human | KLK9 | 284366 | kallikrein-related peptidase 9 | Click here to display 3 evidence detail records. |
Human | NEGR1 | 257194 | neuronal growth regulator 1 | In our small but representative cohort of patients, we have found significant correlations and associations in expression and clinicopathology that suggest a wider role of the family in ovarian cancer. |
Human | PAOX | 196743 | polyamine oxidase (exo-N4-amino) | The results obtained in A2780 ovarian cancer cells by real-time quantitative RT-PCR and Northern blot analysis show that a 2-hour exposure of A2780 cells to platinum drugs induces expression of SSAT, a second SSAT (SSAT-2), spermine oxidase, and polyamine oxidase in a dose-dependent manner. |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | These findings provide rationale for evaluation of ASNS protein expression as a predictive biomarker of clinical L-ASP activity in ovarian cancer.[L-ASP] |
Human | CLEC4C | 170482 | C-type lectin domain family 4, member C | The BDCA-1/BDCA-2 DCs ratio in peritoneal fluid of patients with serous cystadenoma was significantly higher in comparison to ovarian cancer. CONCLUSIONS: Decreased BDCA-1/BDCA-2 DCs ratio in patients with ovarian cancer may favour Th2 lymphocyte differentiation and/or induction of immunological tolerance. |
Human | PEBP4 | 157310 | phosphatidylethanolamine-binding protein 4 | Click here to display 4 evidence detail records. |
Human | CTCFL | 140690 | CCCTC-binding factor (zinc finger protein)-like | These data establish promoter DNA hypomethylation as a mechanism leading to BORIS expression in human ovarian cancer |
Human | ACVR1C | 130399 | activin A receptor, type IC | The antiproliferative effect of Nodal/ALK7 on ovarian cancer cells is in part mediated by cyclin G2 |
Human | GSTO2 | 119391 | glutathione S-transferase omega 2 | a glutathione S-transferase omega 2 gene polymorphism may havea role in ovarian cancer |
Human | NACC1 | 112939 | nucleus accumbens associated 1, BEN and BTB (POZ) domain containing | NAC-1 regulates Taxol resistance in ovarian cancer |