human : 41
|Human||RFWD2||64326||ring finger and WD repeat domain 2, E3 ubiquitin protein ligase|
COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas.
COP1 is significantly overexpressed in 81% (25 of 32) of breast and 44% (76 of 171) of ovarian adenocarcinoma as assessed by in situ hybridization and immunohistochemistry.
|Human||PRAME||23532||preferentially expressed antigen in melanoma|
the 4 biomarkers CLU, ITGB3, PRAME and CAPG may be used as prognostic factors for patients with stage III serous ovarian adenocarcinomas
The 40-kilodalton processed glycoprotein, mesothelin, is highly expressed in epithelial mesotheliomas and adenocarcinomas of the ovary (serous papillary) and pancreas, but its expression in a large series of other common carcinomas has not been completely explored.
Finally, we show that CA125 and mesothelin are co-expressed in advanced grade ovarian adenocarcinoma.
This study suggests that these proteins, especially PP5 and PP11, may be useful as markers in monitoring patients with ovarian adenocarcinomas as well as for their early diagnosis.
Immunohistochemical detection of pregnancy-specific protein (SP1) and placenta-specific tissue proteins (PP5, PP10, PP11 and PP12) in ovarian adenocarcinomas.
|Human||IQGAP1||8826||IQ motif containing GTPase activating protein 1|
Findings suggest the involvement of IQGAP1 in the progression and spread of ovarian adenocarcinomas
Our findings suggest the involvement of IQGAP1 in the progression and spread of ovarian adenocarcinomas.
|Human||PTP4A2||8073||protein tyrosine phosphatase type IVA, member 2|
In order to characterize the membrane changes related to Vinca alkaloid resistance, we raised monoclonal antibodies (mAbs) against a Vincristine resistant subline (OV1/VCR) derived from a human ovarian adenocarcinoma cell line (OV1/p).
|Human||CXCR4||7852||chemokine (C-X-C motif) receptor 4|
We studied a human ovarian adenocarcinoma cell line (OC 314) and investigated the role of CXCR4 activation by SDF-1 in human ovarian cancer.
Moreover, a monoclonal antibody panel for TTF-1, CK-7, and CK-20 may facilitate discrimination between primary and metastasized ovarian adenocarcinomas and/or identifying tumors of pulmonary origin.
|Human||LEFTY2||7044||left-right determination factor 2|
The expression of TGFB4 (ebaf) mRNA was absent in non- mucinous colonic, gastric and ovarian adenocarcinomas and adenocarcinomas of colon metastatic to the liver.
|Human||ST8||6765||suppression of tumorigenicity 8 (ovarian)|
Transfection of NIH3T3 cells with genomic DNA from the human ovarian adenocarcinoma tumor cell line OVCAR-3 identified ovc, a rearranged human DNA sequence which was generated during transfection and which induced both morphological transformation and tumorigenesis.
|Human||SPARC||6678||secreted protein, acidic, cysteine-rich (osteonectin)|
SPARC mRNA was not expressed by ovarian adenocarcinoma or by surface epithelial cells.
|Human||SOD2||6648||superoxide dismutase 2, mitochondrial|
Mn-SOD was also responsive to TNF stimulation in KURAMOCHI, a human ovarian adenocarcinoma cell line.
|Human||SKP2||6502||S-phase kinase-associated protein 2, E3 ubiquitin protein ligase|
CONCLUSIONS: Skp2 expression might play an important role in the development and progression of ovarian adenocarcinomas, and Skp2 overexpression is an independent prognostic marker of ovarian adenocarcinoma patients.
Considerable levels of Skp2 mRNA expression were detected in all ovarian adenocarcinomas examined by semiquantitative PCR.
Positive rates of Skp2 in ovarian adenoma, borderline adenoma, and ovarian adenocarcinoma were 0, 0, and 46.3% (26/56), respectivelyu expression level of Skp2 in ovarian adenocarcinoma was significantly higher than those in ovarian adenoma (P<0.01), and borderline adenoma (P<0.01).
Moreover, the expression levels of Cx43 and Skp2 were independent of age and histological type, but significantly associated with pathologic grade, clinical stage, and positive lymph node metastasis of ovarian adenocarcinoma.
Skp2 mRNA expression was examined by semiquantitative PCR in 32 ovarian adenocarcinomas and in 3 ovarian cancer cell lines.
Skp2 overexpression is a prognostic factor in patients with ovarian adenocarcinoma.
Skp2 overexpression is associated with ovarian adenocarcinoma
Besides, in ovarian adenocarcinoma, expression level of Cx43 was moderately inversely correlated with that of Skp2 (r=-0.48, P<0.01).
|Human||SEMA3F||6405||sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F|
The human ovarian adenocarcinoma cell line HEY showed a similar result as A9 cells, but the small cell lung cancer line GLC45 was unaffected by expression of SEMA3F.
These data reinforce the role of the tumor stroma in ovarian adenocarcinoma and suggest that stromal induction of syndecan-1 contributes to the pathogenesis of this malignancy.
Syndecan-1 was not detected in normal ovary but was present in the epithelial and stromal cells of benign and borderline tumors and in ovarian adenocarcinomas.
|Human||RBL2||5934||retinoblastoma-like 2 (p130)|
Levels of Rb2/p130 protein are increased 5-10-fold following all-trans-retinoic acid (ATRA) treatment of the retinoid-sensitive ovarian adenocarcinoma cell line CAOV3, but not the retinoid-resistant adenocarcinoma cell line SKOV3.
|Human||PTEN||5728||phosphatase and tensin homolog|
Microsatellite instability (MSI) leading to the functional inactivation of the PTEN gene has also been reported for ovarian adenocarcinomas with frequencies varying from 6 to 37%
decreased protein expressions due to increased MMAC gene mutation in advanced endometriosis and ovarian cancers were not observed; a significant difference in MMAC immunostaining between endometriosis and ovarian endometriod adenocarcinoma was seen
Decreased Notch 1 mRNA is associated with ovarian adenocarcinomas compared with adenomas
Quantitative PCR revealed decreased Notch 1 mRNA in ovarian adenocarcinomas compared with adenomas.
|Human||NME1||4830||NME/NM23 nucleoside diphosphate kinase 1|
nm23 expression in malignant ascitic effusions of serous ovarian adenocarcinoma.
|Human||CEACAM6||4680||carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)|
Comparison of immunological reactivity of glycoprotein antigens extracted from individual cases of mucinous and serous ovarian adenocarcinomas was performed taking into account the immunological relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), alpha-1-antichymotrypsin, and alpha-1-acid glycoprotein.
|Human||MMP13||4322||matrix metallopeptidase 13 (collagenase 3)|
Using in situ hybridization, expression of MMP-13 mRNA was detected in 9 of 12 vulvar SCCs, primarily in tumor cells, but not in intact vulvar epithelium, in cervical SCCs (n = 12), or in endometrial (n = 11) or ovarian adenocarcinomas (n = 8).
|Human||MMP2||4313||matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|
Stromal MMP-2 occurs early and may play a role early in ovarian adenocarcinoma invasion
alphav integrins and MMP2 have roles in migration of human ovarian adenocarcinoma cells through endothelial extracellular matrix
|Human||MAP3K1||4214||mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase|
Cisplatin-resistance involves the defective processing of MEKK1 in human ovarian adenocarcinoma 2008/C13 cells.
|Human||MCM5||4174||minichromosome maintenance complex component 5|
MCM-2 and MCM-5 proteins appear to be promising as prognostic markers in patients with ovarian adenocarcinomas
Overexpression of both RAR and RXR restores AP-1 repression in ovarian adenocarcinoma cells resistant to retinoic acid-dependent growth inhibition.