Human | TMEFF2 | 23671 | transmembrane protein with EGF-like and two follistatin-like domains 2 | Methylation testing of fecal DNA using a panel of epigenetic markers (methylated SFRP2, HPP1 and MGMT) may be a simple and promising non-invasive screening method for colorectal carcinoma and precancerous lesions |
Human | TP63 | 8626 | tumor protein p63 | The results indicate that the overexpression of p63 in oral precancerous lesions and squamous cell carcinoma in betel-quid chewers in Sri Lanka may be a useful marker for oral precancerous lesions |
Human | NR0B2 | 8431 | nuclear receptor subfamily 0, group B, member 2 | bile acid induces an increase in the gene expression of COX-2 via the sequential transcriptional induction of SHP and CDX1 in precancerous lesions of human gastric cancer |
Human | TP53 | 7157 | tumor protein p53 | TP53 mutations could be a useful prognostic indicator in precancerous oral lesions |
Human | TNFAIP6 | 7130 | tumor necrosis factor, alpha-induced protein 6 | The tumor necrosis factor alpha induced protein 6 is a potential marker that could be used for early diagnosis and prognosis of cancerous or precancerous lesions |
Human | TLR4 | 7099 | toll-like receptor 4 | TLR-4 Thr399Ileu substitution may be a risk factor for gastritis and precancerous lesions |
Human | SERPINB5 | 5268 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | In gastric carcinogenesis, maspin expression experiences upregulation in gastric precancerous lesions and then slight downregulation with malignant transformation |
Human | PGC | 5225 | progastricsin (pepsinogen C) | results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach |
Human | MUC5AC | 4586 | mucin 5AC, oligomeric mucus/gel-forming | Result suggest that testing of M1/MUC5AC can enhance the detection of precancerous lesions and colon cancer |
Human | MAL | 4118 | mal, T-cell differentiation protein | Loss of MAL expression is aasociated with precancerous lesions of the esophagus |
Human | IL1B | 3553 | interleukin 1, beta | IL-1B -511*T-IL-1RN *1 (T1) haplotype carriers were at decreased risk for gastritis and no significant association was observed for precancerous lesions in North Indians |
Human | GSTM1 | 2944 | glutathione S-transferase mu 1 | GSTT1 null genotype in cervical cell samples may be associated with more severe precancerous lesions of the cervix in a Japanese population |
Human | FOS | 2353 | FBJ murine osteosarcoma viral oncogene homolog | expression of Egr-1, c-fos and cyclin D1 varies in esophageal precancerous lesions and cancer tissues, suggesting an involvement of these genes in the development of esophageal carcinoma |
Human | ACE | 1636 | angiotensin I converting enzyme | Polymorphism in angiotensin-converting enzyme is associated with risk of oral precancerous lesions in nonsmokers |
Human | CREBBP | 1387 | CREB binding protein | overexpression of CBP is detected from the very early stages of laryngeal carcinogenesis, suggesting that CBP may play a role in malignant transformation of precancerous laryngeal lesions |
Human | CDKN2A | 1029 | cyclin-dependent kinase inhibitor 2A | p16 methylation was significantly associated with H. pylori infection in precancerous gastric lesions, suggesting that H. pylori infection could potently induce methylation of p16 CpG island immunohistochemical overexpression of p16 is linked to the presence and pathologic grade of human papillomavirus-induced precancerous cervical lesions Tumor suppressor gene p16 and Rb expression in gastric cardia precancerous lesions from subjects at a high incidence area in northern China |
Human | CASP1 | 834 | caspase 1, apoptosis-related cysteine peptidase | Interleukin-1 Beta gene polymorphism is associated with precancerous lesions in African Americans and Caucasians |
Human | BCL2 | 596 | B-cell CLL/lymphoma 2 | Apoptosis-associated bcl-2 oncogene is abnormally expressed in gastric precancerous lesions |