Genes (75)
Species: human : 73 mouse : 2 | |
Mouse | STAT5B | 6777 | signal transducer and activator of transcription 5B | In the current study we demonstrate specific activation of STAT5B in epithelial cells representing invasive and metastatic prostate cancer. | Mouse | SPARC | 6678 | secreted protein, acidic, cysteine-rich (osteonectin) | By using SPARC (secreted protein, acidic and rich in cysteine)-deficient mice and recombinant SPARC, we demonstrated that SPARC selectively supports the migration of highly metastatic relative to less metastatic prostate cancer cell lines to bone. | Human | MUC5B | 727897 | mucin 5B, oligomeric mucus/gel-forming | In this study, the distribution of the tumor-associated antigens GM2, Tn, sTn, Thompson-Friedenreich antigen (TF), Globo H, Le(y), MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC7, carcinoembryonic antigen, beta chain of human chorionic gonadotropin (hCG beta), HER2/neu, PSMA, and KSA on primary and metastatic prostate cancer and 16 types of normal tissues was compared by immunohistochemistry, using a panel of well-characterized monoclonal antibodies. | Human | KLKP1 | 606293 | kallikrein pseudogene 1 | KLK31P is expressed at lower levels in localized and metastatic prostate cancer cells than in normal prostate cells. | Human | C5orf39 | 389289 | | annexin II and its receptor axis play a central role in prostate cancer metastasis, and prostate cancer utilizes the hematopoietic stem cell homing mechanisms to gain access to the niche | Human | IGSF8 | 93185 | immunoglobulin superfamily, member 8 | Overexpression of EWI2/PGRL in Du145 metastatic prostate cancer cells inhibits cell migration on both fibronectin- and laminin-coated substratum, indicating that EWI2/PGRL directly regulates cell migration. | Human | ELAC2 | 60528 | elaC ribonuclease Z 2 | METHODS: We examined polymorphisms within ELAC2 (S217L, A541T, E622V), MSR1 (P275A, R293X, aIVS5-59c), and RNASEL (E265X, R462Q, D541E) in 150 European-Americans with metastatic prostate cancer and 170 prostate cancer-free controls using pyrosequencing assays. | Human | MUC3B | 57876 | mucin 3B, cell surface associated | In this study, the distribution of the tumor-associated antigens GM2, Tn, sTn, Thompson-Friedenreich antigen (TF), Globo H, Le(y), MUC1, MUC2, MUC3, MUC4, MUC5AC, MUC5B, MUC7, carcinoembryonic antigen, beta chain of human chorionic gonadotropin (hCG beta), HER2/neu, PSMA, and KSA on primary and metastatic prostate cancer and 16 types of normal tissues was compared by immunohistochemistry, using a panel of well-characterized monoclonal antibodies. | Human | ASAP1 | 50807 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | study suggests that the ASAP1 gene plays a role in prostate cancer metastasis and may represent a therapeutic target and/or biomarker for metastatic disease | Human | TRIB2 | 28951 | tribbles homolog 2 (Drosophila) | Expression profiles of androgen independent bone metastatic prostate cancer cells indicate up-regulation of the putative serine-threonine kinase GS3955. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | Tissue microarrays to assess AMACR expression in specimens consisting of benign prostate (n = 108 samples), atrophic prostate (n = 26), prostatic intraepithelial neoplasia (n = 75), localized prostate cancer (n = 116), and metastatic prostate cancer (n = 17) demonstrated mean AMACR protein staining intensity of 1.31 (95% confidence interval, 1.23-1.40), 2.33 (95% CI, 2.13-2.52), 2.67 (95% CI, 2.52-2.81), 3.20 (95% CI, 3.10-3.28), and 2.50 (95% CI, 2.20-2.80), respectively (P<.001). AMACR expression is highest in localized prostate cancer and decreases in metastatic prostate cancer. Recently, AMACR has been demonstrated to be over-expressed in localized and metastatic prostate cancer, suggesting that it may be an important tumor marker. Recently, AMACR has been demonstrated to be overexpressed in localized and metastatic prostate cancer and in high-grade prostatic intraepithelial neoplasia but not in normal prostatic glands, suggesting that it may be an important tumor marker. | Human | HPSE | 10855 | heparanase | heparanase overexpression can facilitate tumor invasion and accelerate bone destruction caused by prostate cancer bone metastasis | Human | NES | 10763 | nestin | Results specify a function for Nestin in cell motility and identify a novel pathway for prostate cancer metastasis | Human | GNA13 | 10672 | guanine nucleotide binding protein (G protein), alpha 13 | Results identify the G12 family proteins Galpha12 and 13 as important regulators of prostate cancer invasion and suggest that these proteins may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality | Human | KLK4 | 9622 | kallikrein-related peptidase 4 | hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in prostate cancer bone metastasis | Human | TRAF4 | 9618 | TNF receptor-associated factor 4 | Basal cells in prostate hypertrophy (n = 6) and prostatic intraepithelial neoplasia (PIN; n = 6) were strongly TRAF-4 positive, but none of the 32 primary and 16 metastatic prostate cancer specimens examined contained TRAF-4-positive malignant cells. | Human | BCAR1 | 9564 | breast cancer anti-estrogen resistance 1 | Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration in a metastatic prostate cancer cell line | Human | TNFRSF10A | 8797 | tumor necrosis factor receptor superfamily, member 10a | The TNFRSF10A Glu228Ala polymorphism may be an independent risk factor for prostate cancer metastasis after radation therapy | Human | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | The expression frequency was significantly higher (RANKL [44%], RANK [49%], and OPG [73%]) in metastatic prostate cancer. | Human | PSCA | 8000 | prostate stem cell antigen | Data suggest that PSCA is a promising tumor marker and potential therapeutic target for patients with metastatic prostate cancer | Human | TUSC3 | 7991 | tumor suppressor candidate 3 | Clone HRF-2 showed a high degree of identity with exons 9, 10 and 11 of N33, a gene that is located within a homozygously deleted region of metastatic prostate cancer. The deletion, in pancreatic tumor cell line MIA-PaCa-2, encompassed two screening loci, D8S549 and D8S1992, and overlapped another previously described homozygous deletion of band 8p22 in a metastatic prostate cancer specimen. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | CXCL12/CXCR4 axis is expressed in prostate cancer bone metastasis and exogenous CXCL12 induced MMP-9 expression To delineate the role of SDF-1 and CXCR4 in metastatic prostate cancer (CaP), positive correlations were established between SDF-1 levels and tumor metastasis. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone Thus high levels of the chemokine receptor CXCR4 induce a more aggressive phenotype in prostate cancer cells and identify CXCR4 as a potential therapeutic target in advanced cases of metastatic prostate cancer. MATERIALS and METHODS: CXCR4 mRNA expression was determined by RT-PCR in 3 metastatic prostate cancer cell lines DU145, LNCaP and PC3, the primary prostate cancer cell line 1542 CPT3X and the normal prostate epithelial cell lines 1542 NPTX and Pre 2.8. the pattern of chemokine receptor CXCR4 expression in patients with metastatic prostate cancer | Human | WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | Up-regulation of Wnt-1 and beta-catenin production in patients with advanced metastatic prostate carcinoma: potential pathogenetic and prognostic implications. | Human | VEGFA | 7422 | vascular endothelial growth factor A | Effect of culturing bone-targeted, metastatic C4-2B prostate cancer cells and bone stromal derived cells under hypoxic conditions on expression of vascular endothelial growth factor family members | Human | HSP90B1 | 7184 | heat shock protein 90kDa beta (Grp94), member 1 | the novel involvement of GRP94 suppression in prostate cancer metastasis |
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