Debug Stats | ### Total Build Time: 99 ms 44.889 KB CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 326 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 229 bytes- Skipping details on:
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Genes (30)
Species: human : 30 | |
Human | GJB4 | 127534 | gap junction protein, beta 4, 30.3kDa | Hyperkeratosis triggered by chronic mechanical irritation Hyperkeratosis, generalized | Human | WNT10A | 80326 | wingless-type MMTV integration site family, member 10A | Hyperkeratosis in epidermis | Human | FERMT1 | 55612 | fermitin family member 1 | Hyperkeratosis of palms and soles | Human | NSDHL | 50814 | NAD(P) dependent steroid dehydrogenase-like | | Human | TP63 | 8626 | tumor protein p63 | | Human | IKBKG | 8517 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | STAGE 2 - Skin papules, verrucous lesions, hyperkeratosis | Human | AAAS | 8086 | achalasia, adrenocortical insufficiency, alacrimia | Hyperkeratosis of the palms and soles | Human | TRPC1 | 7220 | transient receptor potential cation channel, subfamily C, member 1 | We suggest that the anti-apoptotic effect of TRPC1 could potentially contribute to abnormal keratosis in DD | Human | MAP2K2 | 5605 | mitogen-activated protein kinase kinase 2 | Hyperkeratosis (especially extensor surfaces) | Human | NAGA | 4668 | N-acetylgalactosaminidase, alpha- | | Human | MPO | 4353 | myeloperoxidase | Title:Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase.|Association:Not Found|Conclusion:Our findings, although based on small numbers, suggest that the oxidative stress genes MPO and CAT may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions. | Human | LOR | 4014 | loricrin | | Human | KRT86 | 3892 | keratin 86 | Perifollicular hyperkeratosis | Human | KRT83 | 3889 | keratin 83 | Perifollicular hyperkeratosis | Human | KRT81 | 3887 | keratin 81 | Perifollicular hyperkeratosis | Human | KRT16 | 3868 | keratin 16 | | Human | KRT10 | 3858 | keratin 10 | Hyperkeratosis of the palms and soles Migratory plaques of thickened, sharply demarcated erythema and hyperkeratosis | Human | KRT9 | 3857 | keratin 9 | | Human | KRT1 | 3848 | keratin 1 | Streaks of hyperkeratosis along each finger onto the palm Migratory plaques of thickened, sharply demarcated erythema and hyperkeratosis Hyperkeratosis of the palms and soles | Human | INSR | 3643 | insulin receptor | | Human | GJB3 | 2707 | gap junction protein, beta 3, 31kDa | Hyperkeratosis triggered by chronic mechanical irritation Hyperkeratosis, generalized | Human | GJB2 | 2706 | gap junction protein, beta 2, 26kDa | Hyperkeratosis (palms, soles, elbows, knees) | Human | GBA | 2629 | glucosidase, beta, acid | | Human | FLT4 | 2324 | fms-related tyrosine kinase 4 | Hyperkeratosis over edematous areas | Human | ERCC2 | 2068 | excision repair cross-complementing rodent repair deficiency, complementation group 2 | Title:DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis.|Association:Not Found|Conclusion:In conclusion, our findings suggest that the DNA repair gene XPD may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions. Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers. Title:DNA repair gene XPD and susceptibility to arsenic-induced hyperkeratosis.|Association:Not Found|Conclusion:In conclusion, our findings suggest that the DNA repair gene XPD may influence the risk of arsenic-induced premalignant hyperkeratotic skin lesions. Future larger studies are needed to confirm this novel finding and investigate how combinations of different candidate genes and/or other host and environmental factors may influence the risk of arsenic induced skin and other cancers. ERCC2 codon 751 Lys/Lys genotype is significantly associated with arsenic-induced premalignant hyperkeratosis |
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