The Septin 9 (MSF) gene is amplified and overexpressed in mouse mammary gland adenocarcinomas and human breast cancer cell lines.
|Mouse||SEMA3E||9723||sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E|
In vivo, expression of Sema3E in mammary adenocarcinoma cells induces the ability to form experimental lung metastasis, and in vitro, the Sema3E protein exhibits both migration and growth promoting activity on endothelial cells and pheochromocytoma cells.
|Mouse||IL1RL1||9173||interleukin 1 receptor-like 1|
Here we show that the T1 gene is activated in mammary adenocarcinomas of transgenic mice harbouring an H-ras transgene under the control of the mammary-specific whey acidic protein (WAP) promoter.
|Mouse||WNT3||7473||wingless-type MMTV integration site family, member 3|
Wnt-1 and Wnt-3 were originally identified as oncogenes activated by the insertion of mouse mammary tumor virus in virus-induced mammary adenocarcinomas, although they are not expressed in the normal mammary gland.
|Mouse||STAT5A||6776||signal transducer and activator of transcription 5A|
Similar to human breast cancers, a proportion of mammary adenocarcinomas in the WAP-TAg transgenic mouse model demonstrate constitutive Stat5a/b and Stat3 activation.
|Mouse||SCD||6319||stearoyl-CoA desaturase (delta-9-desaturase)|
Stearoyl-CoA desaturase activity in mammary adenocarcinomas carried by C3H mice.
|Mouse||S100A4||6275||S100 calcium binding protein A4|
A composite enhancer that is active in murine mammary adenocarcinoma cells was previously identified in the first intron of the mts1/S100A4 gene.
|Mouse||NOS3||4846||nitric oxide synthase 3 (endothelial cell)|
We provide evidence that NO, derived from iNOS and eNOS activity in LMM3 murine mammary adenocarcinoma cell line, is involved in tumor angiogenesis and in tumor cell migration.
|Mouse||MCM4||4173||minichromosome maintenance complex component 4|
Challenging this notion, a new study in mice shows that a hypomorphic mutation in the gene encoding the replication initiation factor Mcm4 leads to genetic instability and predisposes to mammary adenocarcinomas.
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.
|Mouse||FGF7||2252||fibroblast growth factor 7|
Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.
|Mouse||ETV4||2118||ets variant 4|
PEA3 is overexpressed in mouse metastatic mammary adenocarcinomas.
Recently, transgenic mice bearing the c-erbB-2/neu oncogene have been shown to over-express PEA3 mRNA in mammary adenocarcinomas, suggesting a role for this gene family in mammary tumorigenesis.
|Mouse||EPHA2||1969||EPH receptor A2|
4T1 metastatic mammary adenocarcinoma cells transplanted subcutaneously and orthotopically into EphA2-deficient female mice displayed decreased tumor volume, tumor cell survival, microvascular density, and lung metastasis relative to tumor-bearing littermate controls.
|Mouse||BRCA2||675||breast cancer 2, early onset|
Moreover, homozygosity versus heterozygosity for the Brca2 mutation heavily skewed the tumor spectrum toward mammary adenocarcinoma development in p53(+/-) mice.
Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.
|Mouse||AKT2||208||v-akt murine thymoma viral oncogene homolog 2|
Akt1 Ablation Inhibits, whereas Akt2 Ablation Accelerates, the Development of Mammary Adenocarcinomas in Mouse Mammary Tumor Virus (MMTV)-ErbB2/Neu and MMTV-Polyoma Middle T Transgenic Mice.
|Human||MUC5B||727897||mucin 5B, oligomeric mucus/gel-forming|
In breast adenocarcinoma cell lines expressing multiple EPH members, STAT3 constitutively bound to the promoters of MUC1, MUC4, and MUC5B genes.
|Human||CST9||128822||cystatin 9 (testatin)|
CLM mRNA was barely detected in most tumor cell lines except for breast adenocarcinoma MCF-7 cells and glioblastoma U251 cells, but after LPS or PMA stimulation, CLM expression was increased in myelogenous leukemia cell lines HL-60 and U-937.
|Human||TUBA1C||84790||tubulin, alpha 1c|
The anti-vascular action of the tubulin binding agent combretastatin A-4 phosphate (CA-4-P) has been quantified in two types of murine tumour, the breast adenocarcinoma CaNT and the round cell sarcoma SaS.
|Human||SH3BGRL3||83442||SH3 domain binding glutamic acid-rich protein like 3|
This study showed that, as with normal fibroblasts and U937 histiocytic lymphoma, human MCF7 mammary adenocarcinoma cells were protected from TNF in a concentration-dependent manner by pretreatment with either TNF or purified TIP-B1.
To study the in vivo antitumor activities of IL-21, TS/A murine mammary adenocarcinoma cells were genetically modified to secrete IL-21 (TS/A-IL-21).
|Human||TRPV6||55503||transient receptor potential cation channel, subfamily V, member 6|
TRPV6 may be a novel target for the development of calcium channel inhibitors to treat breast adenocarcinoma expressing TRPV6
|Human||KIN||22944||KIN, antigenic determinant of recA protein homolog (mouse)|
We report for the first time that ionizing radiation and bleomycin, a radiomimetic drug, which produce single- and double-strand breaks, increased expression of KIN in human cells established from tumors, including MeWo melanoma, MCF7 breast adenocarcinoma, and ATM+ GM3657 lymphoblast cells.
|Human||SEMA6B||10501||sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B|
The human MCF-7 breast adenocarcinoma cell line was chosen because it expresses Sema6B at a high level.
|Human||IRF9||10379||interferon regulatory factor 9|
After single-step selection of breast adenocarcinoma cells in paclitaxel, differential display and single gene analysis demonstrated that transcriptional activation of IRF9 and other IFN-responsive genes, independent of IFN, corresponded with resistance to antimicrotubule agents.
|Human||ACOT8||10005||acyl-CoA thioesterase 8|
The ability or inability of certain rodent mammary adenocarcinomas to synthesize medium chain fatty acids in vitro, correlates with the presence or absence of the specific mammary chain-terminating enzyme, thioesterase II.
|Human||TJP2||9414||tight junction protein 2|
In addition to pancreatic adenocarcinoma, ZO-2 was found to be de-regulated in breast adenocarcinoma, but not in colon or prostate adenocarcinoma.