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Genes (70)
Species: human : 70 | |
Human | CCR2 | 729230 | chemokine (C-C motif) receptor 2 | evaluated the possible relation between CCR2 and CCR5 alleles and blood pressure (BP) levels in hypertensive | Human | SLC22A12 | 116085 | solute carrier family 22 (organic anion/urate transporter), member 12 | losartan inhibited URAT1 and thereby it lowered Sur levels in hypertensive patients | Human | WNK4 | 65266 | WNK lysine deficient protein kinase 4 | Mutations in the WNK4 gene identified in Japanese hypertensives may contribute to hypertension and progression of hypertensive complications to some extent | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans | Human | VEGFA | 7422 | vascular endothelial growth factor A | In the development of esophageal varices in portal hypertensive rats, increased TNF-alpha and VEGF may be not an early event, and probably play a role in weakening the esophageal wall and the rupture of esophageal varices | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Knowing the VDR gene polymorphisms status may be helpful in preventing target organ damage in hypertensive patients | Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured in serum from hypertensive patients with LV hypertrophy | Human | TNF | 7124 | tumor necrosis factor | Urinary excretion of TNF-alpha might be an early marker of preclinical target organ damage in hypertensive patients The variant allele of THBS2 is a risk factor for TAA in hypertensive patients, whereas the variant alleles of HSPA8, GPX1, AGT, and TNF are protective against this condition | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | serum level significantly and positively correlated with carotid-femoral pulse wave velocity in hypertensive patients plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal extracellular matrix metabolism | Human | THBD | 7056 | thrombomodulin | thrombomodulin level may be a molecular marker of the latent progression of atherosclerosis in hypertensive patients | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Administration of losartan, but not amlodipine, to hypertensive patients improves structural abnormalities and prevents the production of CTGF and TGF-beta in small arteries | Human | TCF7L2 | 6934 | transcription factor 7-like 2 (T-cell specific, HMG-box) | TCF7L2 rs7903146 T allele is present in obese hypertensive patients as much as in the general population | Human | SELE | 6401 | selectin E | E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured in serum from hypertensive patients with LV hypertrophy | Human | SCNN1G | 6340 | sodium channel, non-voltage-gated 1, gamma subunit | The roles of these missense mutations in the SCNN1B or SCNN1G gene identified in hypertensive patients are not clear in the pathogenesis of hypertension and the regulation of electrolytes | Human | SCNN1A | 6337 | sodium channel, non-voltage-gated 1 alpha subunit | The distribution of genotype and allele frequencies of G2139A, A334T and A663T did not differ significantly between hypertensive subjects and control subjects in both Kazak and Uyghur populations | Human | RGS2 | 5997 | regulator of G-protein signaling 2, 24kDa | Genetic variations of RGS2 were studied in hypertensive patients and in the general population | Human | REN | 5972 | renin | The group of hypertensive obese women showed significantly reduced plasma levels of renin and increased aldosterone/renin quotient (ARQ) compared to obese normotensive women Plasma renin in the hypertensive subjects were lower in the Jordan Valley, but similar to normotensives in Irbid City Silent polymorphisms in the renin promoter and enhancer in hypertensive patients | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | significant contribution of the PPARgamma2(Pro12Ala) and eNOS(4a/b) gene polymorphisms to hypertensive risk in our population (odds ratio, 1.9 and 1.6, respectively), confirmed by multiple logistic regression analysis PPARgamma expression is reduced or lacking in all of the angiogenic plexiform lesions of pulmonary hypertensive lungs and in the vascular lesions of a rat model of severe PH (pulmonary hypertension) Hypertensive subjects with low birth weight or short length at birth and the Pro12Pro variant had raised systolic blood pressure PPARgamma2 pro12Ala polymorphism and insulin resistance in Japanese hypertensive patients | Human | PON1 | 5444 | paraoxonase 1 | PON1 status and the levels of certain biochemical parameters are independently associated with the hypertension in hypertensive and obese hypertensive patients | Human | PLAT | 5327 | plasminogen activator, tissue | Our results show an impaired adrenergic-stimulated t-PA release among essential hypertensive patients, probably mediated via a reduced NO availability | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | polymorphism in the promoter region of OPG is associated with vascular morphology in hypertensive subjects | Human | OLR1 | 4973 | oxidized low density lipoprotein (lectin-like) receptor 1 | the experimental evidence has suggested that LOX-1 may contribute to the development of hypertensive organ damage--REVIEW | Human | NPR3 | 4883 | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) | The novel Npr1 gene 3C variant and the Npr3 gene C(-55) allele are associated with hypertensive family history | Human | NPPB | 4879 | natriuretic peptide B | hypertensive patients with abnormal diurnal BP variation patterns (nondippers, extreme dippers, and risers) showed higher plasma BNP levels than those with normal circadian BP variation (dippers) NT-pro BNP levels tends to be higher in hypertensive subjects with diastolic dysfunction | Human | NPPA | 4878 | natriuretic peptide A | Atrial natriuretic hormone in the hypertensive subjects were lower in the Jordan Valley and lower in Irbid City than normotensives |
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