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Genes (57)
Species: human : 57 | |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | HLA-DQ2/8 is associated with endothelial microvascular dysfunction in young patients with juvenile type 1 diabetes [HLA-DQ2 and Hla-DQ8] | Human | RETN | 56729 | resistin | mRNA resistin negatively influences FMV, and is a possible in vivo index of endothelial dysfunction | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells | Human | DDAH1 | 23576 | dimethylarginine dimethylaminohydrolase 1 | Demonstrate a critical role for DDAH-1 and endogenous methylarginines in the pathogenesis of endothelial dysfunction | Human | SIRT1 | 23411 | sirtuin 1 | Sirt1 exerts a protective effects against endothelial dysfunction by preventing stress-induced premature senescence | Human | KERA | 11081 | keratocan | No evidence that endothelial dysfunction and germline mutation of lumican and keratocan genes participate in the etiology of subepithelial corneal haze | Human | NAMPT | 10135 | nicotinamide phosphoribosyltransferase | Circulating levels of visfatin and adiponectin are associated with endothelial dysfunction in all stages of chronic kidney disease, independently of inflammation and insulin resistance | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Adiponectin protects against endothelial dysfunction and cellular disruption induced by oxLDL, with this effect being due, in part, to maintenance of intracellular GSH levels Angiotein II-induced oxidative stress and endothelial dysfunction are accompanied by a decrease in adiponectin gene expression Adiponectin may play a protective role against the atherosclerotic vascular change, and loss of effects enhances endothelial dysfunction, as in obese people Observations suggest that hypoadiponectinemia is associated with impaired endothelium-dependent vasorelaxation and that the measurement of plasma adiponectin level might be helpful as a marker of endothelial dysfunction | Human | NRP1 | 8829 | neuropilin 1 | role for Npn-1 in regulating endothelial barrier dysfunction in response to VEGF | Human | PLA2G7 | 7941 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | The increased values of VEGF, PLA2-LDL and P-selectin in patients with long standing pulmonary hypertension are related to severe endothelial dysfunction and may have prognostic values | Human | VWF | 7450 | von Willebrand factor | Endothelial dysfunction exists in atrial fibrillation and is related to dysfuncion of VWF levels Elevation of vWF in plasma was associated with neuropathic foot ulceration, linking endothelial dysfunction to foot ulceration | Human | VEGFA | 7422 | vascular endothelial growth factor A | Decreased plasma total antioxidant activity, NO, and VEGF levels in patients with metabolic syndrome may reflect significant endothelial dysfunction free plasma VEGF levels are high in chronic renal impairment; may contribute to the endothelial dysfunction of uraemia VEGF impaired bradykinin-mediated dilatation and enhanced basal tone and permeability of isolated arteries which might indicate a potential role for VEGF in the development of endothelial dysfunction in pregnancy | Human | TNF | 7124 | tumor necrosis factor | Endothelial dysfunction is a selective feature of Crohn's disease and is beneficially affected by intravascular TNF-alpha neutralization | Human | SOD3 | 6649 | superoxide dismutase 3, extracellular | A common gene variant in the heparin-binding domain of ecSOD, which is a risk factor for ischemic heart disease, may be a risk factor for vascular maladaptation and endothelial dysfunction in heart failure Common human gene variant of ECSOD fails to protect against endothelial dysfunction produced by an inflammatory stimulus | Human | SELE | 6401 | selectin E | Endothelial dysfunction exists in atrial fibrillation and is related to dysfuncion of E selectin levels higher levels of E-selectin and ICAM-1 were consistently associated with increased diabetes risk in a multiethnic cohort of U.S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes | Human | ROCK1 | 6093 | Rho-associated, coiled-coil containing protein kinase 1 | ROCK has a role in ischemia-induced endothelial dysfunction during stroke | Human | PRKCB | 5579 | protein kinase C, beta | ApoCIII activates PKCbeta, which inhibits the IRS-1/PI3K/Akt/eNOS pathway and induces endothelial dysfunction | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Endothelial PPAR gamma is a critical mediator of vascular function; its loss through dominant-negative interference in the aorta of transgenic mice causes endothelial dysfunction through a mechanism involving oxidative stress | Human | PON1 | 5444 | paraoxonase 1 | 192Q>R allelic variant of the paraoxonase-1 gene is associated with coronary endothelial dysfunction and contributes to early atherosclerosis in humans | Human | PLA2G2A | 5320 | phospholipase A2, group IIA (platelets, synovial fluid) | increased sPLA(2) activity in inflammation in the presence of cells that have lost their membrane phospholipid asymmetry can lead to LPA-mediated endothelial dysfunction and loss of vascular integrity | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Results concllude that elevated PAI-1 levels may be associated with an increased risk for diabetes as a marker for underlying endothelial dysfunction rather than by a direct effect of genetically mediated elevated levels | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | Altogether, these findings suggest that increased OPG production represents an early event in the natural history of diabetes mellitus, possibly contributing to disease-associated endothelial cell dysfunction | Human | OLR1 | 4973 | oxidized low density lipoprotein (lectin-like) receptor 1 | mediates the action of oxidized LDL that induces the decrease in NO release and the increased expression of adhesion molecules, which are typical changes in endothelial dysfunction Upregulation of LOX-1 by linoleic acid may contribute to endothelial dysfunction associated with type 2 diabetes | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Although both eNOS polymorphisms induced endothelial dysfunction, the eNOS T-786C polymorphism may be associated with adiponectin levels, whereas the Glu298Asp polymorphism may be associated with atherogenic lipid levels no evidence for altered enzyme function of the eNOS mutant that could explain endothelial dysfunction associated with the E298D polymorphism NOS3 is also related to hypertension, endothelial dysfunction and variation on serum cholesterol in young adults with acute myocardial infarction Endothelial dysfunction in chronic kidney disease may be partly mediated by advanced glycation end product-induced inhibition of endothelial nitric oxide synthase through RAGE activation | Human | NOS2 | 4843 | nitric oxide synthase 2, inducible | Endothelial nitric oxide synthase gene polymorphism is associated with endothelial dysfunction in healthy young men |
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