Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | association of Lp-PLA(2) levels with arterial disease events implies a role for this enzyme in atherogenesis, our findings suggest that it is not prothrombotic[Lipoprotein-associated phospholipase A2] |
Human | PDGFD | 80310 | platelet derived growth factor D | PDGF-D is present in the neointima of the arteriopathy of Chronic allograft nephropathy, where it can engage PDGF-Rbeta to promote mesenchymal cell migration, proliferation, and neointima formation |
Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:|Association:Not Found|Conclusion:Not Found |
Human | NOTCH3 | 4854 | notch 3 | A model that invokes novel pathogenic roles for the mutant NOTCH3 protein rather than compromised NOTCH3 function as the primary determinant of the CADASIL arteriopathy |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | Title:Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renalangiography cohort.|Association:Not Found|Conclusion:We hypothesize that the Asp allele of the Glu298Asp polymorphism may predispose to the development of atherosclerotic lesions but that renal artery involvement depends on other factors, also. |
Human | MYH11 | 4629 | myosin, heavy chain 11, smooth muscle | Human MYH11 gene mutations provide the first example of a direct change in a specific smooth muscle cell protein leading to an inherited arterial diseases |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | MTHFR C677T and MTHFR A1289C genotypes and haplotypes are connected with tHcy plasma levels in Macedonian patients with occlusive artery disease and deep venous thrombosis The researchers found no association between MTHFR-677 and MTHFR-1298 polymorphisms with occlusive artery disease or deep venous thrombosis |
Human | ITGB3 | 3690 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy |
Human | ITGAV | 3685 | integrin, alpha V | alphavbeta3 integrin is transiently up-regulated (and activated) in graft arteriopathy |
Human | INS | 3630 | insulin | C-peptide may play an active role in atherogenesis in diabetic patients and suggest a new mechanism for accelerated arterial disease in diabetes |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | IL6 gene polymorphisms appear to be important genetic factors in premature coroanry artery disease, and in the regulation of key atherogenic markers in Asian Indian families |
Human | GP1BA | 2811 | glycoprotein Ib (platelet), alpha polypeptide | The polymorphisms affecting the structure or level of the main adhesive platelet glycoproteins (GPs) plays a minor role in genetic risk factors for arterial thrombotic disorders |
Human | FGB | 2244 | fibrinogen beta chain | Association of fibrinogen beta single nucleotide polymorphism FGB(-455) with severe caroltid artery disease is confirmed |
Human | ENG | 2022 | endoglin | Title:Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations.|Association:Not Found|Conclusion:A common polymorphism in ALK1 is associated with sporadic BAVM, suggesting that genetic variation in genes mutated in familial BAVM syndromes may play a role in sporadic BAVMs. |
Human | ACE | 1636 | angiotensin I converting enzyme | Title:Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renalangiography cohort.|Association:Not Found|Conclusion:We hypothesize that the Asp allele of the Glu298Asp polymorphism may predispose to the development of atherosclerotic lesions but that renal artery involvement depends on other factors, also. |
Human | CST3 | 1471 | cystatin C | mild renal impairment detected by elevated cystatin C is associated with both the occurrence and the severity of coronart artery disease, independent of the other risk factors |
Human | AGTR1 | 185 | angiotensin II receptor, type 1 | Title:Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renalangiography cohort.|Association:Not Found|Conclusion:We hypothesize that the Asp allele of the Glu298Asp polymorphism may predispose to the development of atherosclerotic lesions but that renal artery involvement depends on other factors, also. |
Human | AGT | 183 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Title:Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renalangiography cohort.|Association:Not Found|Conclusion:We hypothesize that the Asp allele of the Glu298Asp polymorphism may predispose to the development of atherosclerotic lesions but that renal artery involvement depends on other factors, also. Title:Angiotensinogen and Plasminogen Activator Inhibitor-1 Gene Polymorphism in Relation to Renovascular Disease.|Association:Not Found|Conclusion:Not Found |
Human | ACVRL1 | 94 | activin A receptor type II-like 1 | Title:Polymorphisms in transforming growth factor-beta-related genes ALK1 and ENG are associated with sporadic brain arteriovenous malformations.|Association:Y|Conclusion:A common polymorphism in ALK1 is associated with sporadic BAVM, suggesting that genetic variation in genes mutated in familial BAVM syndromes may play a role in sporadic BAVMs. |