Genes (50)
Species: human : 49 mouse : 1 | |
Mouse | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | Whereas Pms2-deficient mice do not develop intestinal tumors, mice deficient in Pms2 and heterozygous for Min, an allele of Apc, develop approximately three times the number of small intestinal adenomas and four times the number of colon adenomas relative to Min and Pms2+/-;Min mice. | Human | SLC5A8 | 160728 | solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 | SLC5A8 exon 1 methylation is an early event, detectable in colon adenomas, and in even earlier microscopic colonic aberrant crypt foci. | Human | UGT1A6 | 54578 | UDP glucuronosyltransferase 1 family, polypeptide A6 | CYP2C9 and UGT1A6 genotypes modulate the protective effect of aspirin on colon adenoma risk. | Human | A4GNT | 51146 | alpha-1,4-N-acetylglucosaminyltransferase | Formalin-fixed, paraffin-embedded tissue sections from esophagus, stomach, colon, liver, pancreas, lung, kidney, prostate, breast, and salivary gland resected for carcinoma, as well as salivary gland adenoma, colon adenoma, and metastatic adenocarcinoma of lymph nodes from stomach, pancreas, colon, and breast, were immunostained for MUC6, alpha4GnT, and GlcNAcalpha1-->4Galbeta-->R. | Human | AMACR | 23600 | alpha-methylacyl-CoA racemase | In this study, we investigated expression of AMACR in 242 cases of colonic tumors including 176 colorectal carcinomas, 38 colon adenomas and 28 hyperplastic (non-neoplastic) polyps by immunohistochemical analysis. Sixty-four percent of high-grade prostatic intraepithelial neoplasia and 75% colonic adenomas demonstrated positive AMACR protein expression. | Human | STRAP | 11171 | serine/threonine kinase receptor associated protein | Here, in order to investigate the roles of STRAP in colorectal carcinogenesis, the expression of the STRAP protein was investigated in 59 colonic adenomas and 123 colorectal cancers by immunohistochemistry. | Human | SPINT2 | 10653 | serine peptidase inhibitor, Kunitz type, 2 | The HAI-2/PB immunoreactivity was well conserved in the colonic adenoma-carcinoma sequence, and this protein may have important unknown function in the intestinal mucosa. | Human | DHRS9 | 10170 | dehydrogenase/reductase (SDR family) member 9 | Recent studies indicate that human colon adenomas and carcinomas lack retinol dehydrogenases (RDHs) and that APC regulates the expression of human RDHL. Microarray and reverse transcriptase-PCR analyses revealed reduced expression of two retinoid biosynthesis genes: retinol dehydrogenase 5 (RDH5) and retinol dehydrogenase L (RDHL) in colon adenomas and carcinomas as compared with normal colon. | Human | PDZK1IP1 | 10158 | PDZK1 interacting protein 1 | Furthermore, the expression of DD96 is induced in immortalized breast ductal epithelial cell lines compared with normal breast ductal epithelial cells, and, in vivo, in premalignant conditions, such as adenoma of the colon and ductal carcinoma in situ of the breast. | Human | KLF4 | 9314 | Kruppel-like factor 4 (gut) | We compared Gklf expression in intestinal and colonic adenomas to normal mucosa in multiple intestinal neoplasia (Min) mice and familial adenomatous polyposis (FAP) patients, respectively, using semi-quantitative RT-PCR. We previously showed that GKLF expression is decreased in intestinal and colonic adenomas, respectively, from multiple intestinal neoplasia (Min) mice and familial adenomatous polyposis (FAP) patients. | Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | We have recently demonstrated by Northern blot and RT-PCR that the mRNA expression of the alpha-chemokine hIRH/SDF-1alpha is reduced in hepatocellular carcinoma (HCC), several digestive tract cancers and premalignant colon adenomas, and that its receptor CXCR4 mRNA expression is reduced in HCC. | Human | ZNF217 | 7764 | zinc finger protein 217 | The gene copy number of ZNF217 was assessed in 100 colon carcinomas (19 Dukes; A, 42 Dukes; B and 39 Dukes; C), 13 colonic adenomas and 10 normal colon samples. | Human | VEGFA | 7422 | vascular endothelial growth factor A | The mRNA expression levels of Vascular Endothelial Growth Factor A was greater in tissues of early and advanced colon cancer compared with colon adenoma | Human | CLEC3B | 7123 | C-type lectin domain family 3, member B | Colonic adenomas, benign precursors of adenocarcinomas, showed fewer tetranectin positive goblet cells and in some cases showed tetranectin expression in the stroma. | Human | TERC | 7012 | telomerase RNA component | hTR and hTERT expressions were detected by in situ hybridization and reverse transcription following polymerase chain reaction, respectively, in 15 colonic adenomas, 19 sporadic colonic cancers at various histological stages, and 3 normal colonic mucosa samples. | Human | STK11 | 6794 | serine/threonine kinase 11 | We studied 27 colonic adenomatous polyps from familial adenomatous polyposis (FAP), two polyps of the small bowel from Peutz-Jeghers syndrome (PJS), and four colorectal juvenile polyps from juvenile polyposis syndrome (JPS). | Human | SPN | 6693 | sialophorin | Colon adenoma and cancer cells aberrantly express the leukocyte-associated sialoglycoprotein CD43. CD43 is a leukocyte-associated sialoglycoprotein which is also expressed in human colon adenoma and carcinoma. Detection of CD43 (leukosialin) in colon adenoma and adenocarcinoma by novel monoclonal antibodies against its intracellular domain. CD43 is an abundant transmembrane sialoglycoprotein in leukocyte-type cell lines, but it has also been suggested to be present in colon adenomas and colon carcinomas. Immuno-histochemical analysis of paraffin sections from colon adenoma and carcinoma tissues as well as colon cancer cell lines revealed that CD43 was predominantly localised intracellularly, in contrast to leukocyte-type cells. | Human | SEPP1 | 6414 | selenoprotein P, plasma, 1 | Previously, we have demonstrated dramatically reduced SeP expression in human colon adenomas. | Human | PRKCA | 5578 | protein kinase C, alpha | Furthermore, we have determined the expression of PKC alpha, -beta1, -beta2, -delta and -epsilon in colonic adenomas smaller than 1 cm in diameter of 18 patients and found a significant increase of PKC alpha in the cytosolic fraction and decreased membrane levels of PKC beta2 in adenomas compared to normal, neighboring mucosa while protein levels of PKC beta1, -delta and -epsilon were not altered. RESULTS: In both AOM-induced colonic adenomas and carcinomas, a significant down-regulation of PKC-alpha, -delta, and -zeta and an up-regulation of PKC-beta11 were found compared with control colonocytes. | Human | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | Adenomatous colonic polyps | Human | PLK1 | 5347 | polo-like kinase 1 | METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. | Human | DRG1 | 4733 | developmentally regulated GTP binding protein 1 | Compared to normal colon mucosa, Drg1 mRNA expression is decreased in colon adenomas and adenocarcinomas. | Human | MSH2 | 4436 | mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) | Adenomatous colonic polyps | Human | MMP7 | 4316 | matrix metallopeptidase 7 (matrilysin, uterine) | Matrix metalloproteinase-7 overexpression is thought to be an early event in the colonic adenoma-carcinoma pathway | Human | MLH1 | 4292 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | Adenomatous colonic polyps |
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