Genes (47)
Species:
human : 47 | |
| Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | NKp30 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide | | Human | TPH2 | 121278 | tryptophan hydroxylase 2 | Title:Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims.|Association:Y|Conclusion:This is the first report about an association between TPH2 gene polymorphisms and completed suicide. Our findings provide evidence for an involvement of genetic variants in the TPH2 gene in suicidal behavior. These results might open up new research strategies for the analysis of the observed disturbances in the serotonergic system in several other psychiatric disorders. No association with history of suicide was found for the -473T > A and -8396G > C polymorphisms of the TPH2 gene in subjects with schizophrenia or bipolar disorder study reports the learning process of decision-making in suicide attempters to be modulated by four serotonergic gene polymorphisms, 5HTTLPR, TPH1 A218C, MAOA u-VNTR, and TPH2 rs1118997 | | Human | PPP1R1B | 84152 | protein phosphatase 1, regulatory (inhibitor) subunit 1B | We found a significant difference in gene expression levels between SCZ patients who died by suicide (SCZ-S) (n=6) vs. other causes of death (SCZ-NS) (P<0.004), as well as between SCZ-S and UC (P<0.04) | | Human | NCR1 | 9437 | natural cytotoxicity triggering receptor 1 | NKp46 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide | | Human | NCR2 | 9436 | natural cytotoxicity triggering receptor 2 | NKp44 is not only a triggering molecule essential for antitumor activity but is also a surface receptor involved in natural killer cell suicide | | Human | TBX19 | 9095 | T-box 19 | Overtransmission of a haplotype GAC at the TBX19 locus was associated with increased angry/hostility scores among suicide attempters | | Human | YWHAE | 7531 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | Title:Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese.|Association:Y|Conclusion:This finding suggests that 14-3-3 epsilon is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide. 14-3-3 epsilon is a potential suicide susceptibility gene and implies that dysregulation of neurogenesis may be involved in suicide | | Human | XBP1 | 7494 | X-box binding protein 1 | XBP1 polymorphism (-116C/G) is not involved in susceptibility to suicide | | Human | WFS1 | 7466 | Wolfram syndrome 1 (wolframin) | Did not find evidence of an increased incidence of WFS carriers in the suicide panel and concluded that WFS1 carrier status is not a significant contributor to suicide in the general population | | Human | UCN | 7349 | urocortin | The Ucn1-mRNA level in non-preganglionic Edinger-Westphal nucleus neurons is about 9.12 times higher in male but unchanged in female suicide victims | | Human | TTR | 7276 | transthyretin | Serotonergic hypofunction in depression, reflected by low CSF 5-HIAA, may result in decreased choroid plexus transthyretin production, alterations in central thyroid hormone kinetics, and increased vulnerability to suicidal ideation and perhaps suicide | | Human | TPH1 | 7166 | tryptophan hydroxylase 1 | Title:|Association:Not Found|Conclusion:Not Found Title:Intronic polymorphism of tryptophan hydroxylase and serotonin transporter: indication for combinedeffect in predisposition to suicide|Association:Not Found|Conclusion:Concurrent presence of the two, allegedly transcriptionally less active, variants of these genes seems to be in some kind of relation to the increased susceptibility to suicide. Title:Polymorphisms of the tryptophan hydroxylase gene and serotonin 1A receptor gene in suicide victims among Japanese.|Association:Not Found|Conclusion:In conclusion, no significant relation could be established statistically concerning the serotonin related genes between the suicide samples and control samples in Akita. Title:Serotonin transporter gene may be involved in short-term risk of subsequent suicide attempts.|Association:Not Found|Conclusion:These results suggest that the 5-HTTLPR SS genotype is associated with further suicide attempts among patients who have previously attempted suicide. The TPH CC genotype in elderly victims of violent suicide points to the possible combined effect of the respective genetic factor and physiological changes during aging on the predisposition to this disorder study reports the learning process of decision-making in suicide attempters to be modulated by four serotonergic gene polymorphisms, 5HTTLPR, TPH1 A218C, MAOA u-VNTR, and TPH2 rs1118997 Title:Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis.|Association:Y|Conclusion:A significant association was observed between the A218C polymorphism and suicidal behavior using the fixed effect method and the random effect method. The analysis of the sources of heterogeneity showed that two studies (one positive and one negative) significantly deviated from the calculated global effect. The meta-analysis performed after removing those two studies also revealed a significant association between the TPH A218C polymorphism and suicidal behavior. Both analyses suggested that the A allele has a dose-dependent effect on the risk of suicidal behavior. THis enzyme's immunoreactivity is altered by the genetic variation in postmortem brain samples of both suicide victims and controls Title:|Association:Not Found|Conclusion:Not Found | | Human | TK1 | 7083 | thymidine kinase 1, soluble | Clinical-grade preparation of regulatory T-cells encoding the TK1 suicide gene as a safety gene is reported | | Human | TH | 7054 | tyrosine hydroxylase | study does not support the involvement of tyrosine hydroxylase gene variants as major contributors to suicide, whereas dopa decarboxylase variants could mediate some features related to suicide and be involved in violent suicidal behavior | | Human | TACR1 | 6869 | tachykinin receptor 1 | studied gene variants of Tachykinin Receptor 1 in 167 suicide attempters (affective spectrum n = 107, schizophrenia spectrum n = 35, borderline personality disorder n = 25), 92 individuals who committed suicide and 312 healthy subjects | | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Click here to display 18 evidence detail records. | | Human | SLC6A3 | 6531 | solute carrier family 6 (neurotransmitter transporter), member 3 | Title:5HTTLPR polymorphism in schizophrenic patients:further support for association with violent suicide attempts.|Association:Y|Conclusion:Although replication studies are warranted, these results in schizophrenia further support the hypothesis that 5HTTLPR polymorphism is a risk factor for violent suicidal behavior. | | Human | RGS2 | 5997 | regulator of G-protein signaling 2, 24kDa | These findings suggest that RGS2 is genetically involved in the biological susceptibility to suicide in the Japanese population | | Human | RAF1 | 5894 | v-raf-1 murine leukemia viral oncogene homolog 1 | selective reduction in catalytic activity and expression of B-Raf but not Raf-1 suggest that B-Raf may be playing an important role in altered ERK signaling in brain of suicide subjects, and thus in the pathophysiology of suicide | | Human | MAPK7 | 5598 | mitogen-activated protein kinase 7 | Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects | | Human | PRKAR2B | 5577 | protein kinase, cAMP-dependent, regulatory, type II, beta | there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta | | Human | PRKACB | 5567 | protein kinase, cAMP-dependent, catalytic, beta | there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta | | Human | POLB | 5423 | polymerase (DNA directed), beta | dL residues may not be readily repaired by "short-patch" base excision repair but instead function as suicide substrates in the formation of protein-DNA cross-links that may require alternative modes of repair | | Human | OPRM1 | 4988 | opioid receptor, mu 1 | the A118G SNP of the OPRM1 gene is associated with suicide | | Human | NTRK2 | 4915 | neurotrophic tyrosine kinase, receptor, type 2 | A reduction of TrkB.T1 expression in the frontal cortex of a subpopulation of suicide completers is associated with the methylation state of the promoter region Messenger RNA levels of BDNF and trk B were significantly reduced, independently and as a ratio to neuron-specific enolase, in both prefrontal cortex and hippocampus in suicide subjects, as compared with those in control subjects |
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