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Genes (16)
Species: human : 16 | |
Human | AICDA | 57379 | activation-induced cytidine deaminase | Title:|Association:Not Found|Conclusion:The 7888C/T polymorphism might be associated with the pathogenesis of atopic asthma and the regulation of total serum IgE levels. | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:|Association:Not Found|Conclusion:Not Found | Human | STAT6 | 6778 | signal transducer and activator of transcription 6, interleukin-4 induced | Title:|Association:Y|Conclusion:We conclude that the human STAT6 gene is rather involved in the development of eosinophilia and changes in total IgE levels than contributing to the pathogenesis of asthma. Title:|Association:Y|Conclusion:We conclude that the human STAT6 gene is rather involved in the development of eosinophilia and changes in total IgE levels than contributing to the pathogenesis of asthma. | Human | PAFAH1B1 | 5048 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | Title:|Association:Y|Conclusion:Not Found | Human | IL13RA1 | 3597 | interleukin 13 receptor, alpha 1 | Title:|Association:Y|Conclusion:Not Found | Human | IL13 | 3596 | interleukin 13 | Title:A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children.|Association:Y|Conclusion:Our results suggest that the R130Q polymorphism of the IL-13 gene is associated with elevated serum total and allergen-specific IgE but not asthma in Chinese children. Title:A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children|Association:Y|Conclusion:Our results suggest that the R130Q polymorphism of the IL-13 gene is associated with elevated serum total and allergen-specific IgE but not asthma in Chinese children. | Human | IL4R | 3566 | interleukin 4 receptor | Title:|Association:Not Found|Conclusion:Not Found Title:|Association:Y|Conclusion:Not Found | Human | IL4 | 3565 | interleukin 4 | Title:|Association:Y|Conclusion:Our data suggest that the IL-4 promoter C-590T polymorphism may be associated with the development of asthma in Japanese children, but not through modulating total serum IgE levels. | Human | IGH@ | 3492 | | Title:|Association:Not Found|Conclusion:Not Found | Human | HLA-DRB1 | 3123 | | Title:|Association:Not Found|Conclusion:We observed that HLA-DR 4 and DR7 alleles are significantly implicated in their susceptibility to the disease and suggest that this susceptibility is more related to atopy than to specific responses to allergens. According to previous studies, we could also submit that in atopic patients with asthma, DR4 alleles at the least, could be more closely associated with atopy than with asthma per se. Conversely, we suggest that some allelic DQA1 and DQB1 sequences might confer protection against the disease. Title:|Association:Not Found|Conclusion:The weak associations observed after stratification for specific IgE might point to a contribution of genes in these regions to the development of allergy. | Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | Title:|Association:Not Found|Conclusion:Not Found | Human | MS4A2 | 2206 | membrane-spanning 4-domains, subfamily A, member 2 | Title:|Association:Not Found|Conclusion:Not Found Title:|Association:Y|Conclusion:Not Found | Human | CTLA4 | 1493 | cytotoxic T-lymphocyte-associated protein 4 | Title:Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases.|Association:Y|Conclusion:In females only, the CTLA-4 (+49), but not the IL-4 promoter (-590), polymorphism was significantly associated with elevation of total IgE levels and allergic rhinitis. Here, we have, for the first time, demonstrated a gender-linked genetic relationship with allergic disease. | Human | CMA1 | 1215 | chymase 1, mast cell | Title:|Association:Not Found|Conclusion:Not Found | Human | CD14 | 929 | CD14 molecule | Title:|Association:Y|Conclusion:Not Found Title:|Association:Y|Conclusion:We conclude that CD14/-159 plays a significant role in regulating serum sCD14 levels and total serum IgE levels. | Human | ADRB2 | 154 | adrenoceptor beta 2, surface | Title:|Association:Y|Conclusion:The glutamine 27 beta2-adrenoceptor polymorphism appears to contribute to IgE variability in families with asthma. However, it seems that although both amino acid 16 and 27 beta2-adrenoceptor polymorphisms are disease-modifying in subjects with asthma, they do not contribute markedly to the development of the asthmatic phenotype. |
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