Debug Stats | ### Total Build Time: 23 ms 28.399 KB CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 316 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_DEFINITION gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes - Skipping details on:
CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=1 ms Completed: 0 ms rowSize= 15 bytesCONCEPT_RELATIONSHIPS gt=0 Completed: 0 ms rowSize= 106 bytesCONCEPT_GENES gt=21 ms Completed: 21 ms rowSize= 26.773 KBCONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.144 KBCONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes- Reload Stats
|
Genes (23)
Species: human : 23 | |
Human | DAOA | 267012 | D-amino acid oxidase activator | SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT association and epistasis analyses of the DAOA/G30 and DAO loci in a sample of 373 cases with DSM-IV schizophrenia/schizoaffective disorder and 812 controls from the Republic of Ireland | Human | IL23R | 149233 | interleukin 23 receptor | IL23R is a susceptibility gene for inflammatory bowel disease with suggestive epistasis with the IBD5 locus in the Crohn's disease population | Human | NOD2 | 64127 | nucleotide-binding oligomerization domain containing 2 | Presence of the IBD5 risk alleles, particularly in the homozygous state, is associated with IBD and especially with CD, without a significant epistasis with CARD15 | Human | IBD5 | 50941 | inflammatory bowel disease 5 | IL23R is a susceptibility gene for inflammatory bowel disease with suggestive epistasis with the IBD5 locus in the Crohn's disease population | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | Biologic epistasis between SLC6A4 and BDNF in the human brain by identifying a neural mechanism linking signaling on the neural systems level and having implications for treatment planning in depression | Human | PRODH | 5625 | proline dehydrogenase (oxidase) 1 | we found evidence for COMT and PRODH epistasis: in patients with a COMT Val allele (rs4680) and with one or two mutated PRODH alleles, we observed increased WM density in the left inferior frontal lobe | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | PPARA | 5465 | peroxisome proliferator-activated receptor alpha | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Data suggest that PI3K-C2beta and AKT are epistatic to intersectin, and show that ITSN, independent of its role in endocytosis, regulates a critical cellular signaling pathway necessary for cell survival | Human | LPL | 4023 | lipoprotein lipase | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | LIPC | 3990 | lipase, hepatic | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | IL10 | 3586 | interleukin 10 | the presence of epistasis between MHC with humoral systems, such as IL-10, could be underlying the susceptibility/resistance to Chagas' disease | Human | IL5RA | 3568 | interleukin 5 receptor, alpha | Multifactor dimensionality reduction (MDR) test was applied to detect epistasis, and identified single-IL4R(Q576R)- and three-IL4R(Q576R), IL5RA(-80), CD14(-260)- locus association models that predict multiple sclerosis risk with 75-76% accuracy | Human | FCGR2B | 2213 | Fc fragment of IgG, low affinity IIb, receptor (CD32) | The FcgammaRIIb transmembrane polymorphism is a strong disease susceptibility candidate in epistasis with other genetic effects in Taiwanese and other Asian populations | Human | DSG1 | 1828 | desmoglein 1 | data demonstrate the role of epistasis between individual genes in Pemphigus foliaceus susceptibility and illustrate the genetic complexity of organ-specific autoimmune diseases; Epistasis between DSG1 and HLA class II genes | Human | DRD2 | 1813 | dopamine receptor D2 | although there is a protein-protein interaction in the brain, there is no genetic association of the ADORA2A, either alone or in epistasis with DRD2, and the risk of schizophrenia | Human | CSF2 | 1437 | colony stimulating factor 2 (granulocyte-macrophage) | No association was found for CSF2(colony stimulating factor 2) single nucleotide polymorphisms and lung function, nor was there evidence of epistasis | Human | COMT | 1312 | catechol-O-methyltransferase | epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes | Human | BRCA2 | 675 | breast cancer 2, early onset | BRCA2 is epistatic to FA genes for ICL repair, but not for damage-induced modification of FANCD2 and may act downstream form FANCD2 | Human | APP | 351 | amyloid beta (A4) precursor protein | A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region | Human | APOE | 348 | apolipoprotein E | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | APOC3 | 345 | apolipoprotein C-III | Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PPARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile | Human | ADORA2A | 135 | adenosine A2a receptor | although there is a protein-protein interaction in the brain, there is no genetic association of the ADORA2A, either alone or in epistasis with DRD2, and the risk of schizophrenia |
|