| Debug Stats | ### Total Build Time: 80 ms 42.996 KB CONCEPT_NAME gt=6 ms Completed: 6 ms rowSize= 324 bytesCONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytesCONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 267 bytes- Skipping details on:
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CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 188 bytes- Skipping details on:
CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes CONCEPT_PARENTS gt=3 ms Completed: 3 ms rowSize= 556 bytesCONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytesCONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 1.530 KBCONCEPT_RELATIONSHIPS gt=44 ms Completed: 44 ms rowSize= 12.563 KBCONCEPT_GENES gt=23 ms Completed: 23 ms rowSize= 26.416 KBCONCEPT_XREFS gt=3 ms Completed: 3 ms rowSize= 1.147 KBCONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes- Reload Stats
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Genes (21)
Species: human : 21 | |
| Human | OIT3 | 170392 | oncoprotein induced transcript 3 | D8C, a novel domain present in LZP, mutates in familial juvenile hyperuricemia | | Human | SLC22A12 | 116085 | solute carrier family 22 (organic anion/urate transporter), member 12 | SLC22A12 is a major gene for hypouricemia but not hyperuricemia in Japanese | | Human | SLC22A11 | 55867 | solute carrier family 22 (organic anion/urate transporter), member 11 | hOAT4 is the long-postulated, low-affinity apical urate anion exchanger that facilitates hydrochlorothiazide-associated hyperuricemia | | Human | CLDN16 | 10686 | claudin 16 | | | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Ezetimibe, a Selective Inhibitor of the Transport of Cholesterol 1165-1170 Hyperuricemia is significantly associated with visceral fat accumulation and reduced serum adiponectin levels in Japanese men | | Human | ALMS1 | 7840 | Alstrom syndrome 1 | | | Human | UMOD | 7369 | uromodulin | a mutation in UMOD gene may lead to familial nephropathy associated with hyperuricemia Mutant uromodulin causes uricemic underexcretion and hyperuricemia D8C, a novel domain present in UMOD, mutates in familial juvenile hyperuricemia | | Human | TNF | 7124 | tumor necrosis factor | the genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption | | Human | HNF1B | 6928 | HNF1 homeobox B | Hyperuricemia and young-onset gout are consistent features of the phenotype associated with HNF-1beta mutations, but the mechanism is uncertain | | Human | PRPS1 | 5631 | phosphoribosyl pyrophosphate synthetase 1 | | | Human | PPP1R3A | 5506 | protein phosphatase 1, regulatory subunit 3A | | | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | | | Human | PFKM | 5213 | phosphofructokinase, muscle | | | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | | | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | mutation of the MTHFR gene is implied by the study results to be a risk factor of hyperuricemia in elderly Korean men Mutation of 5-MTHFR C677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia | | Human | HPRT1 | 3251 | hypoxanthine phosphoribosyltransferase 1 | A new mutation in the HPRT gene has been determined in one patient with complete deficiency of erythrocyte activity, with hyperuricemia and gout but without Lesch-Nyhan disease mutational analysis of HPRT in patients with Lesch-Nyhan Disease, HPRT-related hyperuricemia with neurologic dysfunction, and hyperuricemia | | Human | SLC37A4 | 2542 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | | | Human | APOC3 | 345 | apolipoprotein C-III | Title:Response to a Urate-Lowering Diet According to Polymorphisms in the Apolipoprotein AI-CIII-AIV Cluster|Association:Not Found|Conclusion:The response of the biological variables to a urate-lowering diet was mainly influenced by diet. Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03). | | Human | APOA4 | 337 | apolipoprotein A-IV | Title:Response to a Urate-Lowering Diet According to Polymorphisms in the Apolipoprotein AI-CIII-AIV Cluster|Association:Not Found|Conclusion:The response of the biological variables to a urate-lowering diet was mainly influenced by diet. Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03). | | Human | APOA1 | 335 | apolipoprotein A-I | Changes in triglycerides were influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03)in hyperuricemia Title:Response to a Urate-Lowering Diet According to Polymorphisms in the Apolipoprotein AI-CIII-AIV Cluster|Association:Not Found|Conclusion:The response of the biological variables to a urate-lowering diet was mainly influenced by diet. Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03). | | Human | ADRB3 | 155 | adrenoceptor beta 3 | Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males |
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