Human | MAGED4B | 81557 | melanoma antigen family D, 4B | The expressions of the six candidates for a suitable RT-PCR marker [mammaglobin B, carcinoembryonic antigen (CEA), cytokeratin (CK) 20, prostate-specific antigen, and melanoma antigens (MAGE-1 and MAGE-3)] were evaluated in two bile duct cancer cell lines and human biliary tract carcinoma tissues. |
Human | ACTR2 | 10097 | ARP2 actin-related protein 2 homolog (yeast) | Coexpression of Arp2 and WAVE2 was detected in 64 (36%) of 179 invasive ductal carcinomas and in 2 (11%) of 18 ductal carcinomas in situ, but was not detected in any adjacent non-cancerous tissue. |
Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | Immunohistochemistry was performed on sections from 50 patients with pancreatic cancer (n = 27), ampullary cancer (n = 12), low bile duct cancer (n = 3), neuroendocrine tumours (n = 3) and chronic pancreatitis (n = 5), using antibodies raised against collagenase (MMP2), stromelysin (MMP3) and tissue inhibitor of metalloproteinase (TIMP1) and developed using the avidin-biotin complex method. |
Human | SCTR | 6344 | secretin receptor | A novel abnormal spliceoform of the secretin receptor was identified in pancreatic and bile duct cancers and developed as a dual antibody sandwich enzyme-linked immunosorbent assay for measure in the circulation |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | a common PTGS2 variant increases bile duct cancer risk |
Human | ENPP3 | 5169 | ectonucleotide pyrophosphatase/phosphodiesterase 3 | E-NPP3 is involved in the infiltration of neoplastic bile duct carcinoma |
Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | All common bile duct carcinomas, most (67%) ampullary carcinomas in situ and some (43%) ampullary carcinomas had moderate to strong nm23-H1 immunostaining. |
Human | MGAT5 | 4249 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | To elucidate the mechanism by which the GnT-V gene is expressed in a cell- and tissue-specific manner, cell-restricted expression was analyzed using the 5;-upstream regions of the human GnT-V gene spanning base pairs -2760 to +23 in a human bile duct carcinoma cell line, HuCC-T1. 233, 18-26). To elucidate the mechanism by which the GnT-V gene is expressed in a cell- and tissue-specific manner, cell-restricted expression was analyzed using the 5;-upstream regions of the human GnT-V gene spanning base pairs -2760 to +23 in a human bile duct carcinoma cell line, HuCC-T1. |
Human | SCGB2A1 | 4246 | secretoglobin, family 2A, member 1 | The expressions of the six candidates for a suitable RT-PCR marker [mammaglobin B, carcinoembryonic antigen (CEA), cytokeratin (CK) 20, prostate-specific antigen, and melanoma antigens (MAGE-1 and MAGE-3)] were evaluated in two bile duct cancer cell lines and human biliary tract carcinoma tissues. |
Human | MDK | 4192 | midkine (neurite growth-promoting factor 2) | We examined the expression of the MK gene in specimens of 47 surgically removed human carcinomas of the gastrointestinal organs, namely, gastric, colorectal, hepatocellular, pancreatic, esophageal, ampullary duodenal and bile duct carcinomas. |
Human | MAGEA1 | 4100 | melanoma antigen family A, 1 (directs expression of antigen MZ2-E) | The expressions of the six candidates for a suitable RT-PCR marker [mammaglobin B, carcinoembryonic antigen (CEA), cytokeratin (CK) 20, prostate-specific antigen, and melanoma antigens (MAGE-1 and MAGE-3)] were evaluated in two bile duct cancer cell lines and human biliary tract carcinoma tissues. |
Human | LIMS1 | 3987 | LIM and senescent cell antigen-like domains 1 | METHODS: A polyclonal antibody was raised to a purified 6-histidine PINCH fusion protein and used to evaluate 74 cases comprising 33 breast carcinomas (21 ductal carcinomas, 6 lobular carcinomas, 4 ductal carcinomas in situ, 2 lobular carcinomas in situ), 22 prostate carcinomas, 5 colon carcinomas, 6 lung carcinomas (3 adenocarcinomas and 3 squamous carcinomas), and 8 skin carcinomas (4 basal cell carcinomas and 4 squamous cell carcinomas) by immunoperoxidase histochemistry of formalin-fixed, paraffin-embedded tissues. |
Human | LDLR | 3949 | low density lipoprotein receptor | Male and female carriers of the T allele of LDLR IVS9-30C>T had a 1.5-fold risk of bile duct cancer |
Human | HOXB7 | 3217 | homeobox B7 | Detection of human aspartyl (asparaginyl) Beta-hydroxylase and homeobox b7 mRNA in brush cytology specimens from patients with bile duct cancer. Homeobox B7 (HoxB7) mRNA is overexpressed in biliary cancer cell lines and possibly involved in the pathogenesis of bile duct cancer |
Human | FOXA1 | 3169 | forkhead box A1 | Analysis of FOXA1 expression in breast tissue arrays revealed significantly higher expression in pure ductal carcinomas in situ compared to invasive ductal carcinomas (IDC); and in IDC, high expression of FOXA1 was associated with favorable prognostic factors. |
Human | GFRA1 | 2674 | GDNF family receptor alpha 1 | The authors studied the relation between perineural invasion in patients with bile duct carcinoma and the expression of glial cell line-derived neurotrophic factor (GDNF), GDNF family receptor alpha1 (GFRalpha1), and RET receptor tyrosine kinase, which are expressed in both central and peripheral nerve tissues. |
Human | GALNT3 | 2591 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) | Extra hepatic bile duct carcinomas alter their GalNAc-T3 expression during tumor growth, and the difference in the expression pattern may be associated with lymph node metastasis |
Human | FIGF | 2277 | c-fos induced growth factor (vascular endothelial growth factor D) | MATERIALS AND METHODS: The expressions of HIF-1alpha, VEGF-C and VEGF-D were analyzed in 10 normal mammary epithelia, 12 fibroadenomas, 20 ductal carcinomas in situ (DCISs and 36 invasive ductal carcinomas (IDCs) by immunohistochemistry, comparing clinicopathological parameters. |
Human | ETS1 | 2113 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | Transcriptional regulation of the N-acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC-T1) is mediated by Ets-1. |
Human | EGFR | 1956 | epidermal growth factor receptor | Data provide the first evidence of somatic mutations of the EGFR gene in bile duct carcinoma |
Human | DLAT | 1737 | dihydrolipoamide S-acetyltransferase | Because the expression level of PDC-E2 was elevated in PBC bile duct cells, we tried to construct a bile duct carcinoma cell line that overexpressed PDC-E2 as a PBC cell model. |
Human | ASPH | 444 | aspartate beta-hydroxylase | Human aspartyl (asparaginyl) beta-hydroxylase (HAAH) mRNA is overexpressed in biliary cancer cell lines and possibly involved in the pathogenesis of bile duct cancer |
Human | FASLG | 356 | Fas ligand (TNF superfamily, member 6) | Significantly lower soluble form of fas is associated with bile duct carcinoma |
Human | FAS | 355 | Fas cell surface death receptor | Significantly higher soluble form of fas is associated with bile duct carcinoma |
Human | APOE | 348 | apolipoprotein E | Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of gallstones, a 1.8-fold risk of gallbladder cance, a 3.7-fold risk of bile duct cancer and a 4-fold risk of ampullary cancer |