Human | ABCG2 | 9429 | ATP-binding cassette, sub-family G (WHITE), member 2 | BCRP transports anticancer drugs more efficiently at low pH, independent of the dissociation status of the substrate |
Human | ZAP70 | 7535 | zeta-chain (TCR) associated protein kinase 70kDa | in Jurkat cells, ZAP-70 phosphorylation level increased under acidic environments; results suggest that extracellular low pH stimulates or enhances TCR signaling via ZAP-70 and p38 |
Human | TTR | 7276 | transthyretin | The asymmetry and a possible destabilization of the tetrameric quaternary structure of TTR may be responsible for the amyloidogenic potential of the two TTR mutant forms at low pH conformational changes preceding the formation of amyloid, we performed molecular dynamics simulations of the wild-type monomer, amyloidogenic variants of transthyretin (V30M, L55P, V122I) and a protective variant (T119M) at neutral and low pH |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | The IL-6/STAT3 antiapoptotic pathway is induced by short exposure to bile acid cocktail and low pH |
Human | SLC4A1 | 6521 | solute carrier family 4 (anion exchanger), member 1 | data provide the first demonstration of a defined change in the molecular structure of cdAE1, and also indicate that the structure under physiological conditions is different from the crystal structure determined at low pH |
Human | SEMG2 | 6407 | semenogelin II | antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH |
Human | SEMG1 | 6406 | semenogelin I | antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH |
Human | SELL | 6402 | selectin L | Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils |
Human | PLG | 5340 | plasminogen | Angiostatin, an angiogenesis inhibitor, lowers intracellular pH in cultured endothelial cells under conditions of low extracellular pH, resulting in a decrease in cell migration and an increase in cell death |
Human | NFKB1 | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Data show that, similar to H. pylori, low pH augments NF-kappaB nuclear binding in gastric epithelial cells and appears to be mediated through MEK1-dependent signaling pathways |
Human | MUC2 | 4583 | mucin 2, oligomeric mucus/gel-forming | MUC2 mucin has an autocatalytic cleavage in the C terminus at the low pH of the late secretory pathway |
Human | LTF | 4057 | lactotransferrin | Three specific sites are variably occupied by polar groups in lactoferrin mutants R210G, R210E, and R210L and other Ltf proteins, which when coupled with iron-release data give new insights into factors that most influence iron retention at low pH |
Human | KCNA5 | 3741 | potassium voltage-gated channel, shaker-related subfamily, member 5 | Reduction in the activation energy for the inactivation transition from the open state underlies the inhibition of hKv1.5 Na(+) current at low pH |
Human | GART | 2618 | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | The pH-dependent activity in human GART is due to its inability to bind the substrate, beta-glycinamide ribonucleotide, at low pH on the basis of structural studies at high and low pH |
Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | that exposure to low pH is not required for RANTES or MIP-1beta dissociation from CCR5, or for recycling of internalised CCR5 to the cell surface |
Human | CLIC2 | 1193 | chloride intracellular channel 2 | CLIC2 forms pH-dependent chloride channels in vitro with higher channel activity at low pH levels and that the channels are subject to redox regulation |
Human | CALCA | 796 | calcitonin-related polypeptide alpha | human calcitonin at low local pH could be involved in osteoclasts' calcium-sensitive permeability through channel formation and/or receptor interaction |
Human | B2M | 567 | beta-2-microglobulin | equilibrium denaturation measured by (1)H-(15)N NMR to determine conformational properties of an amyloidogenic intermediate of human beta(2)-microglobulin (beta(2)m) formed at low pH Low pH may stabilize the straight conformation of edge beta-strand D (containing residues with amyloid-like fibril-forming potential) and thus increase the amyloidogenicity of beta 2-microglobulin |
Human | APP | 351 | amyloid beta (A4) precursor protein | biophysical analysis of amyloid beta-protein at low pH and its protofibril formation |