Human | ABCG2 | 9429 | ATP-binding cassette, sub-family G (WHITE), member 2 | BCRP transports anticancer drugs more efficiently at low pH, independent of the dissociation status of the substrate |
Human | ZAP70 | 7535 | zeta-chain (TCR) associated protein kinase 70kDa | in Jurkat cells, ZAP-70 phosphorylation level increased under acidic environments; results suggest that extracellular low pH stimulates or enhances TCR signaling via ZAP-70 and p38 |
Human | TTR | 7276 | transthyretin | conformational changes preceding the formation of amyloid, we performed molecular dynamics simulations of the wild-type monomer, amyloidogenic variants of transthyretin (V30M, L55P, V122I) and a protective variant (T119M) at neutral and low pH The asymmetry and a possible destabilization of the tetrameric quaternary structure of TTR may be responsible for the amyloidogenic potential of the two TTR mutant forms at low pH |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | The IL-6/STAT3 antiapoptotic pathway is induced by short exposure to bile acid cocktail and low pH |
Human | SLC4A1 | 6521 | solute carrier family 4 (anion exchanger), member 1 | data provide the first demonstration of a defined change in the molecular structure of cdAE1, and also indicate that the structure under physiological conditions is different from the crystal structure determined at low pH |
Human | SEMG2 | 6407 | semenogelin II | antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH |
Human | SEMG1 | 6406 | semenogelin I | antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH |
Human | SELL | 6402 | selectin L | Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils |
Human | PLG | 5340 | plasminogen | Angiostatin, an angiogenesis inhibitor, lowers intracellular pH in cultured endothelial cells under conditions of low extracellular pH, resulting in a decrease in cell migration and an increase in cell death |
Human | NFKB1 | 4790 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Data show that, similar to H. pylori, low pH augments NF-kappaB nuclear binding in gastric epithelial cells and appears to be mediated through MEK1-dependent signaling pathways |
Human | MUC2 | 4583 | mucin 2, oligomeric mucus/gel-forming | MUC2 mucin has an autocatalytic cleavage in the C terminus at the low pH of the late secretory pathway |
Human | LTF | 4057 | lactotransferrin | Three specific sites are variably occupied by polar groups in lactoferrin mutants R210G, R210E, and R210L and other Ltf proteins, which when coupled with iron-release data give new insights into factors that most influence iron retention at low pH |
Human | KCNA5 | 3741 | potassium voltage-gated channel, shaker-related subfamily, member 5 | Reduction in the activation energy for the inactivation transition from the open state underlies the inhibition of hKv1.5 Na(+) current at low pH |
Human | GART | 2618 | phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase | The pH-dependent activity in human GART is due to its inability to bind the substrate, beta-glycinamide ribonucleotide, at low pH on the basis of structural studies at high and low pH |
Human | CCR5 | 1234 | chemokine (C-C motif) receptor 5 (gene/pseudogene) | that exposure to low pH is not required for RANTES or MIP-1beta dissociation from CCR5, or for recycling of internalised CCR5 to the cell surface |
Human | CLIC2 | 1193 | chloride intracellular channel 2 | CLIC2 forms pH-dependent chloride channels in vitro with higher channel activity at low pH levels and that the channels are subject to redox regulation |
Human | CALCA | 796 | calcitonin-related polypeptide alpha | human calcitonin at low local pH could be involved in osteoclasts' calcium-sensitive permeability through channel formation and/or receptor interaction |
Human | B2M | 567 | beta-2-microglobulin | Low pH may stabilize the straight conformation of edge beta-strand D (containing residues with amyloid-like fibril-forming potential) and thus increase the amyloidogenicity of beta 2-microglobulin equilibrium denaturation measured by (1)H-(15)N NMR to determine conformational properties of an amyloidogenic intermediate of human beta(2)-microglobulin (beta(2)m) formed at low pH |
Human | APP | 351 | amyloid beta (A4) precursor protein | biophysical analysis of amyloid beta-protein at low pH and its protofibril formation |