Mouse | POSTN | 10631 | periostin, osteoblast specific factor | Ectopic expression of periostin gene by a retrovirus vector suppressed in vitro cell invasiveness of the bladder cancer cells without affecting cell proliferation and tumor growth in nude mice. Periostin may play a role as a suppressor of invasion and metastasis in the progression of human bladder cancers. |
Mouse | PLK1 | 5347 | polo-like kinase 1 | PLK-1 siRNA was successfully transfected into the cells, reduced PLK-1 expression, and prevented the growth of bladder cancer in this mouse model. |
Mouse | LOR | 4014 | loricrin | Loricrin is also expressed in a few parakeratinizing epithelia such as BBN [N-butyl-N-(4-hydroxybutyl)nitrosamine]-induced murine bladder carcinoma and a restricted subset of oral and single vaginal epithelial cells in higher mammals. |
Mouse | KDR | 3791 | kinase insert domain receptor (a type III receptor tyrosine kinase) | CONCLUSION: The extracellular domain of KDR could be expressed in nude mouse bladder cancer tissue and inhibit tumor angiogenesis. |
Mouse | JUP | 3728 | junction plakoglobin | We hypothesize that beta- and gamma-catenin may play an important role in the pathogenesis of bladder cancer. In human bladder cancer, beta- and gamma-catenin expression was significantly weaker than in normal bladder. In summary, alterations in beta- and gamma-catenin are late events favoring tumor progression in mouse BBN-induced bladder cancer. The present study demonstrates that beta- and gamma-catenin may play an important role in bladder cancer progression. |
Mouse | HYAL1 | 3373 | hyaluronoglucosaminidase 1 | These results show that HYAL1 expression in bladder cancer cells regulates tumor growth and progression and therefore serves as a marker for high-grade bladder cancer. |
Mouse | CEACAM1 | 634 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | Rodent biliary glycoprotein (Bgp), also known as C-CAM, has recently been shown to function as a tumor suppressor in colon, prostate, and bladder cancers. |
Human | UCA1 | 652995 | urothelial cancer associated 1 (non-protein coding) | Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development |
Human | H19 | 283120 | H19, imprinted maternally expressed transcript (non-protein coding) | analysis of IGF2 and H19 loss of imprinting in bladder cancer |
Human | FLCN | 201163 | folliculin | Associated endometrial carcinoma, atypical endometrial hyperplasia, uterine leiomyosarcoma, bladder transitional carcinoma, gastric, biliary and renal cell carcinoma |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | NMP22, nuclear matrix protein-22 in urine may be promising tool for screening bladder cancer [NMP22] |
Human | SYNPO2 | 171024 | synaptopodin 2 | Click here to display 6 evidence detail records. |
Human | NRG4 | 145957 | neuregulin 4 | Neuregulin-4 expression is downregulated during urinary bladder cancer progression |
Human | PIGU | 128869 | phosphatidylinositol glycan anchor biosynthesis, class U | Click here to display 5 evidence detail records. |
Human | ARHGEF25 | 115557 | Rho guanine nucleotide exchange factor (GEF) 25 | In line with these data, expression of either p63RhoGEF or GEFT in J82 human bladder carcinoma cells induced the formation of actin stress fibres. |
Human | MAGED4B | 81557 | melanoma antigen family D, 4B | Out of 57 samples of primary transitional-cell carcinomas of the bladder, 12 (21%) expressed MAGE-1 and 20 (35%) expressed MAGE-3. |
Human | COL18A1 | 80781 | collagen, type XVIII, alpha 1 | Lentivirus-mediated gene transfer might represent an effective strategy for expression of angioinhibitory peptides to achieve inhibition of human bladder cancer proliferation and tumor progression |
Human | TSGA10 | 80705 | testis specific, 10 | In malignant tissues, TSGA10 was over-expressed in 4 of 20 hepatocellular carcinomas (HCC), 1 of 20 colon cancers, 7 of 20 ovarian cancers, 3 of 20 prostate cancers, 1 of 21 malignant melanomas, and 8 of 21 bladder cancers. |
Human | ZDHHC11 | 79844 | zinc finger, DHHC-type containing 11 | data suggest that gain of 5p15.33 (TPPP and ZDHHC11) may become a potential biomarker identifying high-risk patients with disease progression in bladder cancer |
Human | BIRC7 | 79444 | baculoviral IAP repeat containing 7 | alpha isoform of LIVIN, which is not expressed in normal bladder tissue, is expressed in a proportion of bladder carcinoma with a high risk of relapse Livin expression may have a role in the development of bladder cancer |
Human | HMGN5 | 79366 | high mobility group nucleosome binding domain 5 | Immunohistochemistry was used to detect the NSBP1 expression in 19 specimens of NP resected during complete cystectomy from patients with bladder carcinoma, and 26 specimens of BPH and 40 specimens of PCa, all resected during operation. |
Human | MBOAT7 | 79143 | membrane bound O-acyltransferase domain containing 7 | RNA analysis demonstrated increased expression of BB1 mRNA in metastatic breast and bladder carcinomas relative to normal breast epithelium and urothelium. |
Human | CSMD1 | 64478 | CUB and Sushi multiple domains 1 | BAC microarray-CGH detects homozygous deletion of CSMD1 in human bladder cancer specimens |
Human | PBOV1 | 59351 | prostate and breast cancer overexpressed 1 | A novel gene, designated UROC28, was identified by an agarose gel-based differential display technique, and it was found to be up-regulated in prostate, breast, and bladder cancer. Cloning and characterization of UROC28, a novel gene overexpressed in prostate, breast, and bladder cancers. |
Human | GNB4 | 59345 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | Intron-1 haplotypes of GNB4 may, thus, serve as predictive markers for progression and survival of patients suffering from bladder cancer |