Genes (56)
Species:
human : 56 | |
| Human | LOC100507436 | 100507436 | | Title:Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification|Association:Not Found|Conclusion:Five different genotyping techniques resolved and confirmed 364 genotypes when both original and Phi29-processed DNA worked in PCRs. General population genetic analyses provided additional evidence that WGA may represent a reliable and simple approach to securing ample genomic DNA for typing HLA, MICA, and related variants. | | Human | VEGFA | 7422 | vascular endothelial growth factor A | Homozygosity of the VEGF -1154A gene may serve as a susceptibility factor affecting for recurrent pregnancy loss Title:Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss.|Association:Y|Conclusion:This is the first report on VEGF gene polymorphisms in women with recurrent miscarriage, demonstrating that the -1154G/A VEGF gene polymorphism is associated with idiopathic recurrent abortions. | | Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Title:An assessment of genetic markers as predictors of bone turnover in healthy adults.|Association:Y|Conclusion:These findings suggest that healthy Irish adults with either the tt or ff VDR genotype have higher rates of bone turnover than those with Tt or TT, or Ff or FF genotypes, respectively, and therefore may have a higher risk of low bone mineral density and osteoporosis in later life. | | Human | TNF | 7124 | tumor necrosis factor | Title:Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause.|Association:Not Found|Conclusion:This finding would support the concept of involvement of IFN-gamma +874 A --> T in the pathogenesis of RPL of unknown cause in the Caucasian Argentine population. Title:Th2/Th3 cytokine genotypes are associated with pregnancy loss|Association:Not Found|Conclusion:Our results suggest that abortive events are determined by genetic factors, reflected in the female patient's immunogenetic profile. Title:Associations between cytokine gene polymorphisms and recurrent pregnancy loss.|Association:Not Found|Conclusion:We believe that the associations of these genotypes with RPL are interesting not only as risk factors but also because they represent another piece of evidence that these cytokines might be important in the pathogenesis of RPL. relationship between recurrent pregnancy loss and polymorphisms of the genes coding for TNF-alpha (-308 G-->A), IL-10 (-1082 G-->A), IL-6 (-174 G-->C), and IFN-gamma (+874 A-->T) TNFalpha polymorphisms and resting blood TNFalpha levels do not correlate with the propensity to recurrent pregnancy loss in Caucasian women TNF-alpha was found to be related to the pregnancy loss Title:Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women.|Association:Not Found|Conclusion:It may be concluded that IL-10 polymorphism at position -592 could be a genetic factor for RPL. | | Human | TIMP1 | 7076 | TIMP metallopeptidase inhibitor 1 | The dysregulated TIMP1 expression is associated with infertility and early pregnancy loss | | Human | TGFB1 | 7040 | transforming growth factor, beta 1 | Title:Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause.|Association:Not Found|Conclusion:This finding would support the concept of involvement of IFN-gamma +874 A --> T in the pathogenesis of RPL of unknown cause in the Caucasian Argentine population. Title:A case-control study in IL6 and TGFB1 gene polymorphisms and recurrent spontaneous abortion in southern Brazilian patients.|Association:Not Found|Conclusion:This result strengthened the importance of IL6 genotypes in the pathogenesis of RSA of unknown cause in the south Brazilian population. Title:Th2/Th3 cytokine genotypes are associated with pregnancy loss|Association:Not Found|Conclusion:Our results suggest that abortive events are determined by genetic factors, reflected in the female patient's immunogenetic profile. | | Human | TCN2 | 6948 | transcobalamin II | Title:A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss.|Association:Not Found|Conclusion:Not Found | | Human | TCN1 | 6947 | transcobalamin I (vitamin B12 binding protein, R binder family) | Title:Gene-gene interaction between fetal MTHFR 677C>T and transcobalamin 776C>G polymorphisms in human spontaneous abortion|Association:Y|Conclusion:Embryos that have combined MTHFR 677TT and TC 776CG or 776GG genotypes; genotypes that individually are associated with impaired homocysteine metabolism in adults, are at increased risk for spontaneous abortion compared with embryos that have only one of these genotypes. | | Human | SPP1 | 6696 | secreted phosphoprotein 1 | Compared with normal pregnancy, osteopontin expression and decidual killer cells accumulation were reduced significantly in recurrent pregnancy loss patients | | Human | PGR | 5241 | progesterone receptor | Title:Association of progesterone receptor polymorphism with recurrent abortions.|Association:Not Found|Conclusion:The data suggest that the rarer PR allele may be associated with an increased likelihood of repeated miscarriages contributing to its multi-factorial causes. | | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Title:Lipoprotein (a) and other prothrombotic risk factors in Caucasian women with unexplained recurrent miscarriage. Results of a multicentre case-control study.|Association:Not Found|Conclusion:Upon univariate analysis the heterozygous FV mutation, Lp(a) > 30 mg/dL, increased APA/ACA and BMI > 25 kg/m(2) in combination with a prothrombotic risk factor were found to be significantly associated with uRM. In multivariate Title:Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages.|Association:Not Found|Conclusion:Based on these results, we recommend the incorporation of these two polymorphisms into the spectrum of thrombophilic mutations which should be analysed in individuals with recurrent spontaneous miscarriages. Patients homozygous for both the ACE D and PAI-1 4G alleles may benefit from the application of low molecular weight heparin as early as possible in the pregnancy in order to prevent uteroplacental microthromboses. Title:Recurrent pregnancy loss and its relation to FV Leiden, FII G20210A and polymorphisms of plasminogen activator and plasminogen activator inhibitor.|Association:Not Found|Conclusion:9/49 women with RPL showed coagulation disorders with heterozygous FV Leiden mutation (5), FXII (1), protein C (1) or protein S (2) deficiency. However, due to the small number of patients studied, no definite conclusion can be drawn. Title:[Association of genetic polymorphisms in plasminogen activator inhibitor-1 gene and 5,10-methylenetetrahydrofolate reductase gene with recurrent early spontaneous abortion]|Association:Not Found|Conclusion:The above findings suggest that genetic polymorphisms of PAI-1 4G/5G and MTHFR C677T were associated with RESA. They may have synergetic impact and present gene dosage effect on the susceptibility to the development of early spontaneous abortion. Title:|Association:Not Found|Conclusion:Not Found | | Human | PAEP | 5047 | progestagen-associated endometrial protein | During first trimester, serum glycodelin and IGFBP-1 are markedly decreased in polycystic ovary syndrome(PCOS), implicating endometrial epithelial and stromal dysfunction during periimplantation and early pregnancy in early pregnancy loss | | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | NO concentration but not the polymorphism of MTHFR and eNOS gene and hyperhomocysteinemia are associated with recurrent pregnancy loss in Japanese Title:Endothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage|Association:Y|Conclusion:These data support a role for the NOS3 gene as a genetic determinant of the risk of idiopathic recurrent miscarriage. The present study identifies and validates a novel polymorphism in the eNOS gene which was found associated with the risk of recurrent early pregnancy loss (REPL) Title:Polymorphisms of the angiotensinogen gene, the endothelial nitric oxide synthase gene, and the interleukin-1beta gene promoter in women with idiopathic recurrent miscarriage.|Association:Not Found|Conclusion:Despite promising experimental data, our data fall short of showing any significant association between a variant of the promoter region of IL1B, the M235T polymorphism of Agt, and the Glu298Asp missense variant of Nos3 and the occurrence of IRM. | | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Click here to display 10 evidence detail records. | | Human | MTHFD1 | 4522 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | Title:|Association:Not Found|Conclusion:Not Found Title:|Association:Not Found|Conclusion:Not Found | | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | The dysregulated MMP9 expression is associated with infertility and early pregnancy loss | | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | The dysregulated MMP2 expression is associated with infertility and early pregnancy loss | | Human | CD46 | 4179 | CD46 molecule, complement regulatory protein | Title:Maternal CD46H*2 and IL1B-511*1 homozygosity in T helper 1-type immunity to trophoblast antigens in recurrent pregnancy loss.|Association:Not Found|Conclusion:The combination of homozygosity for both IL1B-511*1 and CD46H*2 alleles is a high risk factor for RPL-Th1(+). The combination of homozygosity for both IL1B-511*1 and CD46H*2 alleles is a high risk factor for recurrent pregnancy loss | | Human | LTA | 4049 | lymphotoxin alpha | Title:Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women.|Association:Not Found|Conclusion:It may be concluded that IL-10 polymorphism at position -592 could be a genetic factor for RPL. | | Human | JAK2 | 3717 | Janus kinase 2 | The JAK2 V617F mutation, which occurs in 0.20% of normal primigravidas between the ages of 21 and 36 years who live in the Mediterranean region of southern Europe, is associated with an increased risk of pregnancy loss | | Human | INHA | 3623 | inhibin, alpha | findings suggest that inhibin A is a specific marker of early pregnancy loss before the onset of the clinical symptoms of recurrent miscarriage | | Human | IL10 | 3586 | interleukin 10 | Title:Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women.|Association:Not Found|Conclusion:It may be concluded that IL-10 polymorphism at position -592 could be a genetic factor for RPL. Title:Associations between cytokine gene polymorphisms and recurrent pregnancy loss.|Association:Not Found|Conclusion:We believe that the associations of these genotypes with RPL are interesting not only as risk factors but also because they represent another piece of evidence that these cytokines might be important in the pathogenesis of RPL. Title:Associations between cytokine gene polymorphisms and recurrent pregnancy loss.|Association:Y|Conclusion:We believe that the associations of these genotypes with RPL are interesting not only as risk factors but also because they represent another piece of evidence that these cytokines might be important in the pathogenesis of RPL. relationship between recurrent pregnancy loss and polymorphisms of the genes coding for TNF-alpha (-308 G-->A), IL-10 (-1082 G-->A), IL-6 (-174 G-->C), and IFN-gamma (+874 A-->T) Title:Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause.|Association:Not Found|Conclusion:This finding would support the concept of involvement of IFN-gamma +874 A --> T in the pathogenesis of RPL of unknown cause in the Caucasian Argentine population. | | Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | Title:Cytokine gene polymorphisms in recurrent pregnancy loss of unknown cause.|Association:Not Found|Conclusion:This finding would support the concept of involvement of IFN-gamma +874 A --> T in the pathogenesis of RPL of unknown cause in the Caucasian Argentine population. Title:Th2/Th3 cytokine genotypes are associated with pregnancy loss|Association:Not Found|Conclusion:Our results suggest that abortive events are determined by genetic factors, reflected in the female patient's immunogenetic profile. Among Japanese women, those carrying the -634G allele of the IL-6 gene might have a decreased risk of recurrent pregnancy loss Title:A case-control study in IL6 and TGFB1 gene polymorphisms and recurrent spontaneous abortion in southern Brazilian patients.|Association:Not Found|Conclusion:This result strengthened the importance of IL6 genotypes in the pathogenesis of RSA of unknown cause in the south Brazilian population. | | Human | IL4 | 3565 | interleukin 4 | Title:Cytokine gene polymorphisms and susceptibility to recurrent pregnancy loss in Iranian women.|Association:Not Found|Conclusion:It may be concluded that IL-10 polymorphism at position -592 could be a genetic factor for RPL. IL-4 VNTR allele is not a major genetic regulator in recurrent pregnancy loss | | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | no significant differences were found when the frequency of IL-1RN 2 polymorphisms were compared between fertile control couples and couples experiencing recurrent pregnancy loss |
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