Human | CD276 | 80381 | CD276 molecule | B7-H3 is highly expressed in urothelial cell carcinoma across tumor stages, whereas B7-H1 and PD-1 expression are associated with advanced disease |
Human | DDX43 | 55510 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 | the methylation status of the HAGE promoter directly correlates with its expression in both CML cell lines and patients and is associated with advanced disease and poor outcome |
Human | GOLM1 | 51280 | golgi membrane protein 1 | increased expression of GP73 in hepatocytes appears to be a general feature of advanced liver disease, and may be regulated via distinct pathways that involve hepatotropic viruses or cytokines |
Human | UBIAD1 | 29914 | UbiA prenyltransferase domain containing 1 | TERE1 maybe significant in prostate cancer growth regulation and the down regulation or absence of TERE1 may be an important component of the phenotype of advanced disease |
Human | CD274 | 29126 | CD274 molecule | B7-H3 is highly expressed in urothelial cell carcinoma across tumor stages, whereas B7-H1 and PD-1 expression are associated with advanced disease |
Human | EBAG9 | 9166 | estrogen receptor binding site associated, antigen, 9 | wide distribution of EBAG9 and its relation to advanced disease suggest that this protein may play important roles in epithelial ovarian cancer |
Human | TNFRSF6B | 8771 | tumor necrosis factor receptor superfamily, member 6b, decoy | Gastric cancer patients with high DcR3 expression presented more advanced pN2 disease than those with low DcR3 expression |
Human | TP53 | 7157 | tumor protein p53 | Interval between the onset of rheumatoid arthritis and lymphoproliferative disorders development was significantly longer in patiets with p53 gene mutations and had more advanced diseases and an unfavorable prognosis |
Human | TNF | 7124 | tumor necrosis factor | study found no evidence of an interaction between alcohol consumption and TNF-alpha gene polymorphisms in relation to TNF-alpha levels; carriers of the TNF -238A allele tended to have a higher prevalence of advanced liver disease than -238G homozygotes |
Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | Increased sdf1a expression in basal ganglia neurons of patients with advanced HIV CNS disease suggests it may also contribute to pathogenesis |
Human | CCL5 | 6352 | chemokine (C-C motif) ligand 5 | SNP -403G may be associated with increased susceptibility to HIV infection, while -28G may be associated with advanced disease |
Human | RPE65 | 6121 | retinal pigment epithelium-specific protein 65kDa | Gene therapy with this protein to cure Leber congenital amaurosis; Gene therapy in Rpe65(-/-) mice at advanced-disease stages show some success |
Human | PTEN | 5728 | phosphatase and tensin homolog | Data indicates that haploinsufficiency or PTEN genomic loss is an indicator of more advanced disease at surgery, and is predictive of a shorter time to biochemical recurrence of disease |
Human | KLK10 | 5655 | kallikrein-related peptidase 10 | KLK10 expression is up-regulated in CRC and GC and higher expression of KLK10 closely correlates with advanced disease stage, which predicts a poorer prognosis |
Human | PIK3CA | 5290 | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Higher BRCA1 mRNA expression is significantly correlated with advanced disease and ERBB2 overexpression in breast cancers |
Human | SERPINA1 | 5265 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | In individuals with advanced lung disease associated with alpha(1)-antitrypsin deficiency, cytotoxic concentrations of alpha-defensins might be present and unopposed, thus further aggravating lung disease in this population |
Human | PDCD1 | 5133 | programmed cell death 1 | B7-H3 is highly expressed in urothelial cell carcinoma across tumor stages, whereas B7-H1 and PD-1 expression are associated with advanced disease |
Human | MYC | 4609 | v-myc avian myelocytomatosis viral oncogene homolog | Translocation is more common in germinal centre-like B (GCB) cell type of adult diffuse large B-cell lymphoma than in non-GCB type, and associated with advanced disease |
Human | MX1 | 4599 | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | HIV replication unresponsive to antiretroviral treatment in perinatal-infected patients with advanced disease and plasmacytoid dendritic cell depletion may lead to interferon-alpha expression and subsequent induction of MxA mRNA |
Human | MDM2 | 4193 | MDM2 oncogene, E3 ubiquitin protein ligase | MDM2 splice variant expression has been associated with advanced neoplastic disease--REVIEW |
Human | KLRC1 | 3821 | killer cell lectin-like receptor subfamily C, member 1 | HIV-1 infection is associated with higher levels NKG2A in the cytotoxic NK subset in HIV-1-infected patients with more advanced disease |
Human | IL4 | 3565 | interleukin 4 | Lack of antitumor activity and intolerance of this drug in patients with advanced HIV disease and Kaposi's sarcoma |
Human | CYR61 | 3491 | cysteine-rich, angiogenic inducer, 61 | Cyr61 appears to guard against metastatic disease because low expression is associated with more advanced disease; and therefore, expression levels of Cyr61 correlate with the prognosis of lung cancer |
Human | HIF1A | 3091 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Expression correlates with advanced disease stage, increased angiogenesis and poor prognosis in human glioma |
Human | ERBB2 | 2064 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 | HER-2/neu over-expression correlates with more advanced disease in Iranian colorectal neoplasm patients |