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Details
Link-It Detail - Disease - Breast Carcinoma
Debug Stats
  • ### Total Build Time: 1,210 ms 55.404 KB
  • CONCEPT_NAME gt=0 Completed: 0 ms rowSize= 330 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 736 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=0 Completed: 0 ms rowSize= 14 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=0 Completed: 0 ms rowSize= 7 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
  • CONCEPT_RELATIONSHIPS gt=4 ms Completed: 4 ms rowSize= 16.974 KB
  • CONCEPT_GENES gt=1,204 ms Completed: 1.204 Seconds rowSize= 36.169 KB
  • CONCEPT_XREFS gt=2 ms Completed: 2 ms rowSize= 1.150 KB
  • CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Breast Carcinoma C0678222
Definition (1)
A carcinoma arising from the breast, most commonly the terminal ductal-lobular unit. It is the most common malignant tumor in females. Risk factors include country of birth, family history, menstrual and reproductive history, fibrocystic disease and epithelial hyperplasia, exogenous estrogens, contraceptive agents, and ionizing radiation. The vast majority of breast carcinomas are adenocarcinomas (ductal or lobular). Breast carcinoma spreads by direct invasion, by the lymphatic route, and by the blood vessel route. The most common site of lymph node involvement is the axilla.
Relationships (269)

Relation Types:
diso_​to_​anat : 10
diso_​to_​chem : 43
diso_​to_​diso : 40
diso_​to_​gene : 176


Relationships:
disease_​has_​associated_​disease : 1
gene_​associated_​with_​disease : 175
gene_​is_​biomarker_​of : 1
gene_​product_​is_​biomarker_​of : 1
gene_​product_​malfunction_​associated_​with_​disease : 42
is_​abnormal_​cell_​of_​disease : 4
is_​finding_​of_​disease : 2
is_​normal_​cell_​origin_​of_​disease : 1
is_​normal_​tissue_​origin_​of_​disease : 2
is_​not_​abnormal_​cell_​of_​disease : 2
is_​primary_​anatomic_​site_​of_​disease : 1
isa : 33
mapped_​to : 3
parent_​is_​cdrh : 1
Page Size
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Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANATis_primary_anatomic_site_of_diseaseimg Breast C0006141
DISO_to_ANATis_abnormal_cell_of_diseaseimg Cancer Cell C0334227
DISO_to_ANATis_abnormal_cell_of_diseaseimg Carcinoma Cell C1518174
DISO_to_ANATis_normal_cell_origin_of_diseaseimg Epithelial Cells C0014597
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Epithelial Tissue C0014609
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Malignant Stromal Cell C1518246
DISO_to_ANATis_normal_tissue_origin_of_diseaseimg Mammary Epithelium C0596882
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Cell C0597032
DISO_to_ANATis_abnormal_cell_of_diseaseimg Neoplastic Epithelial Cell C1513959
DISO_to_ANATis_not_abnormal_cell_of_diseaseimg Neoplastic Smooth Muscle Cell C1514098
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg ADAM11 Protein C1332016
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg AGR2 protein, human C1332035
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BCAR1 protein, human C1451357
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BCAS1 protein, human C0755807
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BCAS3 Protein C1332621
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BCAS4 protein C1332622
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BRCA1 Associated RING Domain 1 Protein C1332437
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BRCA1 Protein C0259275
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BRCA3 Protein C1332439
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BRCATA protein C1332441
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg BRCD1 Protein C1332445
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg CATHEPSIN D C0007427
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg Catechol O-Methyltransferase C0007407
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg Choline Kinase C0008415
DISO_to_CHEMgene_product_malfunction_associated_with_diseaseimg DLC1 protein, human C0675121
Genes (1926)

Species:
human : 1850
mouse : 76
Page Size
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SpeciesGeneGeneIdGene NameEvidence
MouseADAMTS15170689ADAM metallopeptidase with thrombospondin type 1 motif, 15
img NCI, Score=801, Pubmed Id: 16152618, UMLKSK CUI: C0678222
MousePNCK139728pregnancy up-regulated non-ubiquitously expressed CaM kinase
img NCI, Score=801, Pubmed Id: 11034105, UMLKSK CUI: C0678222
MouseSAT2112483spermidine/spermine N1-acetyltransferase family member 2
img NCI, Score=801, Pubmed Id: 9343946, UMLKSK CUI: C0678222
MouseIL22RA158985interleukin 22 receptor, alpha 1
img NCI, Score=801, Pubmed Id: 17114505, UMLKSK CUI: C0678222
MouseSMOX54498spermine oxidase
img NCI, Score=801, Pubmed Id: 12141946, UMLKSK CUI: C0678222
MouseUTP2027340UTP20, small subunit (SSU) processome component, homolog (yeast)
img NCI, Score=801, Pubmed Id: 9673349, UMLKSK CUI: C0678222
MouseLETMD125875LETM1 domain containing 1
Click here to display 3 evidence detail records.
MouseBRMS125855breast cancer metastasis suppressor 1
Click here to display 3 evidence detail records.
MouseLYVE110894lymphatic vessel endothelial hyaluronan receptor 1
img NCI, Score=801, Pubmed Id: 11175850, UMLKSK CUI: C0678222
MouseSEPT910801septin 9
img NCI, Score=801, Pubmed Id: 12727837, UMLKSK CUI: C0678222
MouseKDM5B10765lysine (K)-specific demethylase 5B
Click here to display 3 evidence detail records.
MouseMRC29902mannose receptor, C type 2
img NCI, Score=801, Pubmed Id: 15967816, UMLKSK CUI: C0678222
MouseST189705suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)
img NCI, Score=801, Pubmed Id: 15489893, UMLKSK CUI: C0678222
MouseCLCA29635chloride channel accessory 2
img NCI, Score=801, Pubmed Id: 10554024, UMLKSK CUI: C0678222
MouseKSR18844kinase suppressor of ras 1
img NCI, Score=801, Pubmed Id: 15684389, UMLKSK CUI: C0678222
MouseHYAL28692hyaluronoglucosaminidase 2
img NCI, Score=801, Pubmed Id: 12584308, UMLKSK CUI: C0678222
MousePEA158682phosphoprotein enriched in astrocytes 15
img NCI, Score=801, Pubmed Id: 9205133, UMLKSK CUI: C0678222
MouseTNFSF118600tumor necrosis factor (ligand) superfamily, member 11
img NCI, Score=801, Pubmed Id: 12237883, UMLKSK CUI: C0678222
MouseLMO48543LIM domain only 4
img NCI, Score=801, Pubmed Id: 15897450, UMLKSK CUI: C0678222
MouseAKAP18165A kinase (PRKA) anchor protein 1
img NCI, Score=801, Pubmed Id: 12576461, UMLKSK CUI: C0678222
MouseWNT10B7480wingless-type MMTV integration site family, member 10B
img NCI, Score=801, Pubmed Id: 9121776, UMLKSK CUI: C0678222
MouseWNT17471wingless-type MMTV integration site family, member 1
img NCI, Score=801, Pubmed Id: 6318122, UMLKSK CUI: C0678222
img NCI, Score=801, Pubmed Id: 3018519, UMLKSK CUI: C0678222
MouseEZR7430ezrin
img NCI, Score=801, Pubmed Id: 15987432, UMLKSK CUI: C0678222
MouseUROD7389uroporphyrinogen decarboxylase
img NCI, Score=801, Pubmed Id: 1526139, UMLKSK CUI: C0678222
MouseTIMP27077TIMP metallopeptidase inhibitor 2
img NCI, Score=801, Pubmed Id: 11309307, UMLKSK CUI: C0678222
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0678222Breast Carcinoma0self