Mouse | ADAMTS15 | 170689 | ADAM metallopeptidase with thrombospondin type 1 motif, 15 | Results observed in FVB-PyMT mice, a robust transgenic model of highly metastatic breast carcinoma, fitted the expectation that relatively high expression levels of ADAMTS8 together with low expression levels of ADAMTS15 seen in human breast carcinoma are associated with a poor clinical outcome. |
Mouse | PNCK | 139728 | pregnancy up-regulated non-ubiquitously expressed CaM kinase | Potentially related to its heterogeneous in vivo expression pattern, Pnck expression is oncogene-associated in murine epithelial cell lines derived from mammary tumors arising in different transgenic mouse models of breast cancer; cell lines derived from mammary tumors initiated by c-myc or int-2/Fgf3 express Pnck, whereas cell lines initiated by neu or H-ras do not. |
Mouse | SAT2 | 112483 | spermidine/spermine N1-acetyltransferase family member 2 | Correlation between GM3/GD3 ratio and SAT-2 activity; (2), mammary carcinomas developed in MMTV/c-neu transgenic mice: accumulation of GM3-derived species. |
Mouse | IL22RA1 | 58985 | interleukin 22 receptor, alpha 1 | In this study, we report that murine breast cancer cells express functional IL-22R as indicated by RT-PCR studies, immunoblotting, and STAT3 activation assays. |
Mouse | SMOX | 54498 | spermine oxidase | A BLAST search using maize PAO sequences identified homologous mammalian cDNAs derived from human hepatoma and mouse mammary carcinoma: the encoded proteins differed by 20 amino acids. |
Mouse | UTP20 | 27340 | UTP20, small subunit (SSU) processome component, homolog (yeast) | Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis. |
Mouse | LETMD1 | 25875 | LETM1 domain containing 1 | Click here to display 3 evidence detail records. |
Mouse | BRMS1 | 25855 | breast cancer metastasis suppressor 1 | Click here to display 3 evidence detail records. |
Mouse | LYVE1 | 10894 | lymphatic vessel endothelial hyaluronan receptor 1 | Using a novel marker for lymphatic endothelium, LYVE-1, we demonstrate here the occurrence of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice. |
Mouse | SEPT9 | 10801 | septin 9 | Real-time PCR analysis revealed a consistently increased expression of septin 9 (Sept9), not only in polyomavirus middle T antigen-induced, but in a wide variety of mouse models of breast cancer. |
Mouse | KDM5B | 10765 | lysine (K)-specific demethylase 5B | Click here to display 3 evidence detail records. |
Mouse | MRC2 | 9902 | mannose receptor, C type 2 | Here, we show that uPARAP/Endo180 has a key role in the degradation of collagen during mammary carcinoma progression. |
Mouse | ST18 | 9705 | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) | We further show that ectopic ST18 expression in MCF-7 breast cancer cells strongly inhibits colony formation in soft agar and the formation of tumors in a xenograft mouse model.Oncogene (2004) 23, 9295-9302. |
Mouse | CLCA2 | 9635 | chloride channel accessory 2 | Our results suggest that CLCA2 may act as a tumor suppressor in breast cancer. |
Mouse | KSR1 | 8844 | kinase suppressor of ras 1 | Nm23-H1 Metastasis Suppressor Expression Level Influences the Binding Properties, Stability, and Function of the Kinase Suppressor of Ras1 (KSR1) Erk Scaffold in Breast Carcinoma Cells. |
Mouse | HYAL2 | 8692 | hyaluronoglucosaminidase 2 | Oncogenic transformation assays using mouse and rat fibroblasts have localized the transforming activity to the Env proteins encoded by these viruses, which require the putative lung and breast cancer tumor suppressor hyaluronidase 2 (Hyal2) to promote virus entry into cells. |
Mouse | PEA15 | 8682 | phosphoprotein enriched in astrocytes 15 | Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers. |
Mouse | TNFSF11 | 8600 | tumor necrosis factor (ligand) superfamily, member 11 | At all stages, RANKL expression was confined to the stromal/osteoblastic cells, whereas PTHrP was confined to the MCF-7 breast cancer cells. |
Mouse | LMO4 | 8543 | LIM domain only 4 | Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. |
Mouse | AKAP1 | 8165 | A kinase (PRKA) anchor protein 1 | PURPOSE: This study investigated whether the functional and structural interactions between epidermal growth factor receptor (EGFR), protein kinase AI (PKAI), and bcl-2/bcl-xL could be exploited to obtain cooperative antitumor effects against models of human colon and breast cancer. |
Mouse | WNT10B | 7480 | wingless-type MMTV integration site family, member 10B | The gene is the human homologue of mouse Wnt10b, recently shown to be one of the oncogenes cooperating with FGF3 in the development of mouse mammary tumour virus (MMTV) induced mouse mammary carcinomas. |
Mouse | WNT1 | 7471 | wingless-type MMTV integration site family, member 1 | The mouse int-1 gene is a putative mammary oncogene discovered as a target for transcriptionally activating proviral insertion mutations in mammary carcinomas induced by the mouse mammary tumor virus in C3H mice. Most mammary carcinomas induced in C3H mice by the mouse mammary tumour virus (MMTV) bear a new proviral insertion within a highly conserved locus on chromosome 15 called int-1. |
Mouse | EZR | 7430 | ezrin | The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. |
Mouse | UROD | 7389 | uroporphyrinogen decarboxylase | Uroporphyrinogen decarboxylase from mouse mammary carcinoma and liver of normal and tumor-bearing mouse. |
Mouse | TIMP2 | 7077 | TIMP metallopeptidase inhibitor 2 | Our findings suggest that overexpression of TIMP-2 delays growth and angiogenesis of mammary carcinoma in vivo and that down-regulation of VEGF expression may play an important role in this TIMP-2-mediated antitumoral and antiangiogenic effects. |