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Data - ToppGene Sources

The vast majority of all data in Gataca is from ToppGene so its credits cover data sources that are used within Gataca. The primary reason for utilizing the same sources between these applications is to help ensure consistancy between them. ToppGene, and Gataca, uses data from over 20 sources.

For ToppGene Credits, please visit:

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Data - GUDMAP

GUDMAP

The GUDMAP data within Gataca is only availble within the GUDMAP interface:

Gataca's GUDMAP

Data - UMLSKS

UMLSKS website

Software

Software - Solr

Solr website

Software - PrototypeJS

Prototype JS website

Prototype JavaScript framework, version 1.7
(c) 2005-2010 Sam Stephenson
 
Prototype is freely distributable under the terms of an MIT-style license.
For details, see the Prototype web site: http://www.prototypejs.org/

Software - script.aculo.us

Script.aculo.us website

NOTE: Only the effects.js and dragdrop.js modules from Script.aculo.us are being used.

// script.aculo.us scriptaculous.js v1.9.0, Thu Dec 23 16:54:48 -0500 2010

// Copyright (c) 2005-2010 Thomas Fuchs (http://script.aculo.us, http://mir.aculo.us)
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Software - canvasXpress

canvasXpress website

CanvasXpress is a javascript library based on the <canvas> tag implemented in HTML5.

This package is currently being used for the Venn Diagram within SetBuilder. Plans are to utilize it in other areas in the generation of other graphs.

Software - Oracle Enterprise Edition

Oracle website

The data within Gataca is being stored in an Oracle 11g database.

Software - Modernizr

modernizr

modernizr provides simple interfacing to check to see what features are available within the client's browser. This is predomantly used to test for HTML 5 features such as canvas or local storage support.

Software - JQTouch

JQTouch website

JQTouch is being used for the mobile edition of Gataca.

Software - jQuery

JQuery website

jQuery is used within JQTouch only.

Software - tablesort

tablesort website

Copyright (c) 2006 Andrew Tetlaw 
http://tetlaw.id.au/view/blog/table-sorting-with-prototype/

Permission is hereby granted, free of charge, to any person
obtaining a copy of this software and associated documentation
files (the "Software"), to deal in the Software without
restriction, including without limitation the rights to use, copy,
modify, merge, publish, distribute, sublicense, and/or sell copies
of the Software, and to permit persons to whom the Software is
furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be
included in all copies or substantial portions of the Software.

Software - Firebug Light

Firebug Light website

firebugx.js - There is no disclaimer in the original file, but it is an open source project. The main website is http://www.getfirebug.com It is an open source project hosted by Google code.

Link-It Detail - Disease - Complete hydatidiform mole

Debug Stats

### Total Build Time: 17 ms 44.750 KB
CONCEPT_NAME gt=2 ms Completed: 2 ms rowSize= 350 bytes
CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 522 bytes
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CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 14 bytes
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CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 15 bytes
CONCEPT_RELATIONSHIPS gt=1 ms Completed: 1 ms rowSize= 106 bytes
CONCEPT_GENES gt=12 ms Completed: 12 ms rowSize= 42.564 KB
CONCEPT_XREFS gt=1 ms Completed: 1 ms rowSize= 1.160 KB
CONCEPT_ANCILLARY gt=0 Completed: 0 ms rowSize= 14 bytes
Reload Stats

Disease (1)

Complete hydatidiform mole C0678213

Definition (1)

Derived from the fertilization of an anuclear ovum by one or sometimes two haploid sperm. Its molar chromosomes derive entirely from the paternal origin. It has no identifiable embryonic or fetal tissue. The chorionic villi have generalized swelling and diffuse trophoblastic hyperplasia. Most complete moles (>90%) have a 46,XX karyotype and the rest 46,XY karyotype.

Genes (21)

Species:

human : 21

Species	Gene	GeneId	Gene Name	Evidence
Human	HOPX	84525	HOP homeobox	NCI, Score=801, Pubmed Id: 14614883, UMLKSK CUI: C0678213 Loss of NECC1 expression, biallelic deletions at the critical (7p12-7q11.23) region and enhanced H19 expression in choriocarcinoma would reflect the genetic features exhibited by the putative forerunner, complete mole.
Human	PHLDA2	7262	pleckstrin homology-like domain, family A, member 2	NCI, Score=801, Pubmed Id: 13129680, UMLKSK CUI: C0678213 The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole. NCI, Score=801, Pubmed Id: 13129680, UMLKSK CUI: C0678213 IPL protein was absent in both of two cases of androgenetic complete hydatidiform mole examined by immunostaining, and IPL mRNA was absent in an additional three cases of this neoplasm examined by northern blotting.
Human	TJP1	7082	tight junction protein 1	NCI, Score=801, Pubmed Id: 11228248, UMLKSK CUI: C0678213 A striking result was the altered expression of ZO-1 and occludin in partial and complete moles.
Human	TIMP1	7076	TIMP metallopeptidase inhibitor 1	NCI, Score=801, Pubmed Id: 10525381, UMLKSK CUI: C0678213 While 8 (73.0%) placentas, 14 (87.5%) partial moles, and 19 (76.0%) complete moles showed strong immunoreactivity for TIMP-1 in syncytiotrophoblasts, no strong staining was found in choriocarcinomas (P < 0.01, P < 0.01, P < 0.01, respectively). NCI, Score=801, Pubmed Id: 10525381, UMLKSK CUI: C0678213 METHODS: Paraffin sections of 16 partial moles, 25 complete moles, 10 gestational choriocarcinomas, and 11 normal first-trimester placentas were studied immunohistochemically for expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, and tissue inhibitor of metalloproteinase-1 (TIMP-1).
Human	ST14	6768	suppression of tumorigenicity 14 (colon carcinoma)	NCI, Score=801, Pubmed Id: 1672240, UMLKSK CUI: C0678213 To determine the genetic origin of the complete hydatidiform mole, 20 abnormal pregnancies were studied with restriction fragment length polymorphism with five genomic probes: EJ 6.6, beta-globin gene, 3;alpha-hypervariable region, J-Bir, and St14.
Human	PGM1	5236	phosphoglucomutase 1	NCI, Score=801, Pubmed Id: 6325316, UMLKSK CUI: C0678213 In the present study, to shed some light on the genesis of trophoblastic tumor, chromosome, HLA and PGM1 polymorphisms were examined for complete moles and choriocarcinomas. NCI, Score=801, Pubmed Id: 2821529, UMLKSK CUI: C0678213 Using chromosomal heteromorphisms, human lymphocyte antigen (HLA) and phosphoglucuromutase 1 (PGM1) polymorphisms, we established the androgenetic origin of complete mole in 84 of 91 cases. NCI, Score=801, Pubmed Id: 2960601, UMLKSK CUI: C0678213 Using chromosomal heteromorphism, HLA and PGM1 polymorphisms, we established the androgenetic origin of complete mole in 82 of 91 cases.
Human	NOS3	4846	nitric oxide synthase 3 (endothelial cell)	NCI, Score=801, Pubmed Id: 9771440, UMLKSK CUI: C0678213 METHODS: The immunoperoxidase technique with an antibody directed against eNOS was applied to paraffin sections from first and second trimester placentas, placenta accreta, partial and complete hydatidiform moles, and choriocarcinoma. NCI, Score=801, Pubmed Id: 9771440, UMLKSK CUI: C0678213 Cells with differentiation to intermediate trophoblast in complete hydatidiform mole and choriocarcinoma also show high levels of eNOS, which may be associated with the haematogenous mode of spread of trophoblastic disease.
Human	NME1	4830	NME/NM23 nucleoside diphosphate kinase 1	NCI, Score=801, Pubmed Id: 12051871, UMLKSK CUI: C0678213 RESULTS: Expression of c-erbB-2 and p53 gene products was significantly increased and expression of nm23 and c-ras products was remarkably decreased in complete hydatidiform moles that progressed into postmolar tumor compared with those that remitted spontaneously after evacuation. NCI, Score=801, Pubmed Id: 11963831, UMLKSK CUI: C0678213 We examined the clinical significance of nm23-H1 expression in complete hydatidiform mole. GENERIF, Score=1000, Pubmed Id: 11963831, UMLKSK CUI: C0678213 expression of nm23-H1 showed a negative relation to invasion, suggesting its use as a potential marker of myometrial invasion in complete hydatidiform moles NCI, Score=801, Pubmed Id: 11963831, UMLKSK CUI: C0678213 Expression of nm23-H1 showed a negative relation to invasion, suggesting its use as a potential marker of myometrial invasion in complete hydatidiform moles. NCI, Score=801, Pubmed Id: 12051871, UMLKSK CUI: C0678213 Formalin-fixed paraffin sections of 50 cases of complete mole that progressed to gestational tumor and 32 cases of complete mole that remitted spontaneously were studied immunohistochemically for c-ras, c-erbB-2, p53, and nm23 proteins. NCI, Score=801, Pubmed Id: 17027071, UMLKSK CUI: C0678213 INTRODUCTION: There is scant information about the expression of CD44 and E-cadherin, two cell adhesion molecules, and the antimetastatic protein nm23-H1, in complete hydatidiform moles. NCI, Score=801, Pubmed Id: 11963831, UMLKSK CUI: C0678213 METHODS: Sections of 105 cases of complete hydatidiform moles (including 25 cases of invasive mole) and 95 cases of gestational age--matched normal placentas were immunohistochemically stained with anti-nm23-H1 antibody, which recognizes the nm23-H1/NDP kinase A gene product. NCI, Score=801, Pubmed Id: 17027071, UMLKSK CUI: C0678213 Expression of CD44, E-cadherin, and antimetastatic protein nm23-H1 in complete hydatidiform moles. NCI, Score=801, Pubmed Id: 11963831, UMLKSK CUI: C0678213 Expression of nm23-H1 protein in relation to myometrial invasion in complete hydatidiform moles. NCI, Score=801, Pubmed Id: 12051871, UMLKSK CUI: C0678213 The relationship between expression of c-ras, c-erbB-2, nm23, and p53 gene products and development of trophoblastic tumor and their predictive significance for the malignant transformation of complete hydatidiform mole. NCI, Score=801, Pubmed Id: 11963831, UMLKSK CUI: C0678213 OBJECTIVE: Although nm23-H1 protein expression has been related to invasion in many cancers, its expression and prognostic significance in complete hydatidiform moles has not yet been investigated. NCI, Score=801, Pubmed Id: 17027071, UMLKSK CUI: C0678213 CONCLUSION: In this preliminary study, there is no relationship between CD44, E-cadherin, and nm23-H1 expression in complete hydatidiform moles and the risk of invasive disease. NCI, Score=801, Pubmed Id: 12051871, UMLKSK CUI: C0678213 OBJECTIVE: The aims of this retrospective study by means of immunohistochemical staining were (1) to study the expression of c-ras, c-erbB-2, p53, and nm23 gene products in complete hydatidiform moles that progress to gestational trophoblastic tumor and in those that remit spontaneously after evacuation, and (2) to estimate the predictive value of the expression of these four gene products in malignant transformation of complete hydatidiform mole. NCI, Score=801, Pubmed Id: 11963831, UMLKSK CUI: C0678213 CONCLUSION: nm23-H1 expression could be used as a marker for accurate evaluation of myometrial invasion in complete hydatidiform mole.
Human	RNR1	4549	s-rRNA	NCI, Score=801, Pubmed Id: 11170827, UMLKSK CUI: C0678213 This strategy resulted in the isolation of four mitochondrial transcripts downregulated in benign, as well as in malignant, trophoblastic diseases encoding the cytochrome oxidase subunit I (COX I), the ATPase subunit 6, the 12S ribosomal RNA (12S rRNA) and the transfer RNA for phenylalanine (tRNA(Phe)).This expression pattern was confirmed by Northern blot in normal early placenta (NEP), complete hydatidiform mole (CHM), persistent gestational trophoblastic disease (PGTD) and the human choriocarcinoma derived cell line JEG-3.
Human	MMP13	4322	matrix metallopeptidase 13 (collagenase 3)	NCI, Score=801, Pubmed Id: 10525381, UMLKSK CUI: C0678213 METHODS: Paraffin sections of 16 partial moles, 25 complete moles, 10 gestational choriocarcinomas, and 11 normal first-trimester placentas were studied immunohistochemically for expression of MMP-1, MMP-2, MMP-3, MMP-9, MMP-13, and tissue inhibitor of metalloproteinase-1 (TIMP-1).
Human	MCM7	4176	minichromosome maintenance complex component 7	NCI, Score=801, Pubmed Id: 14636275, UMLKSK CUI: C0678213 METHODS AND RESULTS: Immunohistochemical staining for MCM7 was performed on 122 samples of paraffin-embedded trophoblastic tissues including 22 normal first-trimester placentas, 12 term placentas, 12 spontaneous miscarriages (SM), 21 partial moles (PM), 44 complete hydatidiform moles (CM), and 11 choriocarcinomas (CCA).
Human	LNPEP	4012	leucyl/cystinyl aminopeptidase	NCI, Score=801, Pubmed Id: 12361682, UMLKSK CUI: C0678213 In this study, we confirmed the distribution of P-LAP and AP-A proteins and messenger RNAs in human trophoblasts in normal placenta and complete hydatidiform mole by immunohistochemical and in-situ hybridization techniques. NCI, Score=801, Pubmed Id: 12361682, UMLKSK CUI: C0678213 Differential distribution of placental leucine aminopeptidase/oxytocinase and aminopeptidase A in human trophoblasts of normal placenta and complete hydatidiform mole.
Human	HLA-G	3135		NCI, Score=801, Pubmed Id: 11518912, UMLKSK CUI: C0678213 STUDY DESIGN: We examined 5 complete hydatidiform mole specimens and 5 partial hydatidiform mole specimens to determine whether HLA-G is expressed by immunohistochemistry and by RNA in situ hybridization analysis. NCI, Score=801, Pubmed Id: 11518912, UMLKSK CUI: C0678213 Furthermore, expression of HLA-G in the complete hydatidiform mole, a naturally occurring androgenote, confirms expression of the paternal allele of HLA-G.
Human	F2RL2	2151	coagulation factor II (thrombin) receptor-like 2	NCI, Score=801, Pubmed Id: 12692840, UMLKSK CUI: C0678213 Likewise, high expression levels of PAR1 and PAR3 were observed in the cytotrophoblast cells of complete hydatidiform mole as compared to minimal levels in normal age-matched placenta.
Human	ENPEP	2028	glutamyl aminopeptidase (aminopeptidase A)	NCI, Score=801, Pubmed Id: 12361682, UMLKSK CUI: C0678213 Differential distribution of placental leucine aminopeptidase/oxytocinase and aminopeptidase A in human trophoblasts of normal placenta and complete hydatidiform mole.
Human	DAB2	1601	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	NCI, Score=801, Pubmed Id: 9696034, UMLKSK CUI: C0678213 Subsequent study using immunohistochemistry showed high levels of DOC-2/hDab2 protein expression in normal trophoblast tissues but significantly lower levels of expression in gestational trophoblastic disease tissues, particularly in complete mole and choriocarcinoma.
Human	CSF1R	1436	colony stimulating factor 1 receptor	NCI, Score=801, Pubmed Id: 9513871, UMLKSK CUI: C0678213 OBJECTIVE: To determine the expression of bcl-2, c-myc, c-fms and c-erbB-2 oncoproteins in normal placentas, partial and complete hydatidiform moles, and choriocarcinomas and to examine the possible presence of mutations in the K-ras gene in complete moles and choriocarcinomas. NCI, Score=801, Pubmed Id: 9513871, UMLKSK CUI: C0678213 CONCLUSION: Our data suggest that c-myc, c-erbB-2, c-fms and bcl-2 oncoproteins may be important in the pathogenesis of complete mole and choriocarcinoma.
Human	CDKN1C	1028	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	GENERIF, Score=884, Pubmed Id: 12514787, UMLKSK CUI: C0678213 findings support the hypothesis that misexpression of p57 is involved in the abnormal development of androgenetic complete moles
Human	CCNE1	898	cyclin E1	NCI, Score=801, Pubmed Id: 11598175, UMLKSK CUI: C0678213 The different expression patterns of cyclin E and E2F-1 in partial and complete moles may be useful in distinguishing these two entities. NCI, Score=801, Pubmed Id: 11598175, UMLKSK CUI: C0678213 Cyclin E was maximally expressed by complete moles and choriocarcinomas, and showed an inverse relationship with the cyclin-dependent kinase inhibitor p27(kip1). NCI, Score=801, Pubmed Id: 10931468, UMLKSK CUI: C0678213 RESULTS: The cyclin E indexes (CEI) were as follows: 25.7% +/- 6.2% for hydropic change, 35.3% +/- 12.7% for triploid partial moles, 42.2% +/- 13.1% for diploid/tetraploid complete moles, and 63.6% +/- 9.5% for choriocarcinomas. NCI, Score=801, Pubmed Id: 11598175, UMLKSK CUI: C0678213 In this study we investigated the immunostaining patterns of G(1) restriction point and G(1)-S regulatory proteins E2F-1, Cdk2, cyclin E, p27(kip1), and the proliferation marker Ki-67 on routinely processed sections of 29 hydatidiform moles (10 partial moles and 19 complete moles, including 9 persistent moles), 7 choriocarcinomas, and 7 normal placentas.
Human	ASCL2	430	achaete-scute complex homolog 2 (Drosophila)	GENERIF, Score=1000, Pubmed Id: 17165436, UMLKSK CUI: C0678213 Negative expression of HASH2 in complete hydatidiform moles (CM) but positive expression in malignant tumors suggests the presence of a specific mechanism for inactivation of the HASH2 gene in CM and reactivation in invasive moles or choriocarcinoma
Human	APOB	338	apolipoprotein B	NCI, Score=801, Pubmed Id: 2066110, UMLKSK CUI: C0678213 Five of these revealed DNA segments unique to the paternal APOB allele, allowing us to diagnose a complete mole.

XRefs (1)

XRef Types:

cui : 1

ToppGene Datasets:

none : 1

ToppGene Datasets	XRef Type	XRef Id	XRef	Values	Source	Top % Rank
	CUI	C0678213	Complete hydatidiform mole	0		self

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