Genes (46)
Species: human : 45 mouse : 1 | |
Mouse | PRSS21 | 10942 | protease, serine, 21 (testisin) | Stable expression of Testisin in the Testisin-negative Tera-2 testicular cancer line suppressed tumorigenicity as revealed by inhibition of both anchorage-dependent cell growth and tumour formation in an SCID mouse model of testicular tumorigenesis. | Human | SCGB3A1 | 92304 | secretoglobin, family 3A, member 1 | Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1). | Human | NANOG | 79923 | Nanog homeobox | We provide evidence for the fetal origin of testicular cancer as we detected strong expression of NANOG in fetal gonocytes up to gestational week 20, with subsequent down-regulation occurring earlier than for OCT-4. NANOG is a new marker for testicular carcinoma in situ and germ cell tumours | Human | ERVK6 | 64006 | | HERV-K expression was also common to testicular carcinoma in situ as well as gonocytes of dysgenetic gonads. | Human | CYSLTR2 | 57105 | cysteinyl leukotriene receptor 2 | In this study, we investigate the role of the calcium-sensing receptor (CaR), a G protein-coupled receptor (GPCR), in regulating PTTG in a widely used model of humoral hypercalcemia of malignancy, the rat H-500 Leydig cell testicular cancer. | Human | KLK14 | 43847 | kallikrein-related peptidase 14 | In this paper, the expression of KLK5, KLK10, KLK13 and KLK14 in testicular cancer and their possible roles during testicular cancer development, as well as their clinical applications are briefly reviewed. | Human | KLK13 | 26085 | kallikrein-related peptidase 13 | In addition, differential expression of the KLK-L4 gene was found in various histological types of testicular cancer. In this paper, the expression of KLK5, KLK10, KLK13 and KLK14 in testicular cancer and their possible roles during testicular cancer development, as well as their clinical applications are briefly reviewed. Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer. | Human | KLK5 | 25818 | kallikrein-related peptidase 5 | In this paper, the expression of KLK5, KLK10, KLK13 and KLK14 in testicular cancer and their possible roles during testicular cancer development, as well as their clinical applications are briefly reviewed. | Human | CHEK2 | 11200 | checkpoint kinase 2 | As DNA breaks occur commonly during gametogenesis, and p53 is wild-type and overexpressed in testicular cancer, we examined abundance and localisation of the Chk2 protein during normal development of human testes, and at various stages of germ-cell tumour (GCT) pathogenesis. | Human | CDC37 | 11140 | cell division cycle 37 | In addition, we found that a LKB1 point mutation identified in a sporadic testicular cancer, weakens the interaction of LKB1 with both Hsp90 and Cdc37/p50 and enhances its sensitivity to the destabilizing effect of geldanamycin. | Human | PRSS21 | 10942 | protease, serine, 21 (testisin) | The recently characterized human serine protease, Testisin, is expressed on premeiotic testicular germ cells and is a candidate type II tumor suppressor for testicular cancer. Testisin is a recently identified human serine protease expressed by premeiotic testicular germ cells and is a candidate tumor suppressor for testicular cancer. | Human | MVP | 9961 | major vault protein | In our present work we studied the expression of LRP in testicular cancers. For example, low rates of LRP positivity were seen in testicular cancer, neuroblastoma, and acute myeloid leukemia; intermediate in ovarian cancer; and high in colon, renal, and pancreatic carcinomas. | Human | CCNA1 | 8900 | cyclin A1 | Cyclin A1 is a tissue-specific cyclin that is highly expressed in acute myeloid leukemia and in testicular cancer. Compared to normal spermatogenesis, testicular cancers expressed on average lower levels of cyclin A1. | Human | XIST | 7503 | X inactive specific transcript (non-protein coding) | XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer. | Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | To evaluate the role of these molecules as possible tumor markers in patients with urological malignancies, we examined the serum levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cellcular adhesion molecule-1 (VCAM-1) and E-selectin in patients with renal cell-, bladder-, prostate- and testicular cancer. | Human | TSPY1 | 7258 | testis specific protein, Y-linked 1 | TSPY was also strongly immunostained in early testicular carcinoma in situ (CIS), while seminomatous tumour cells stained less intensely. | Human | TRO | 7216 | trophinin | Because the process of tumor metastasis resembles that of trophoblast invasion and proliferation during embryo implantation, we hypothesized that testicular cancers that synthesize hCG express trophinin thus becoming aggressive trophoblast-like cells. | Human | STK11 | 6794 | serine/threonine kinase 11 | In addition, we found that a LKB1 point mutation identified in a sporadic testicular cancer, weakens the interaction of LKB1 with both Hsp90 and Cdc37/p50 and enhances its sensitivity to the destabilizing effect of geldanamycin. To address the incidence of LKB1 epigenetic inactivation in primary tumors, we analysed colorectal, breast, gastric, pancreatic, thyroid, bladder and testicular carcinomas (n=195). Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Together, these findings suggest that somatic mutations of LKB1 are not frequent in colorectal and testicular cancer. | Human | SLC2A3 | 6515 | solute carrier family 2 (facilitated glucose transporter), member 3 | Only in Glut3-positive testicular carcinomas were most tumor cells Glut3-positive. | Human | RNF4 | 6047 | ring finger protein 4 | Small nuclear RING finger protein (SNURF/RNF4) is a steroid receptor coregulator that is down-regulated in testicular germ cell cancer. Down-regulation of estrogen receptor beta and transcriptional coregulator SNURF/RNF4 in testicular germ cell cancer. | Human | PTPN13 | 5783 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | This study indicates that production of FasL by the germ cell tumour cells might be involved in the early development of these types of adult testicular cancer by inducting apoptosis of Fas-positive, Fap-1-negative tumour-infiltrating lymphocytes. | Human | PTN | 5764 | pleiotrophin | CONCLUSIONS: PTN and FGF-2 may represent promising new diagnostic markers for testicular cancer with high sensitivity even in early-stage testicular cancer. Marked increase of the growth factors pleiotrophin and fibroblast growth factor-2 in serum of testicular cancer patients. | Human | KLK10 | 5655 | kallikrein-related peptidase 10 | In this paper, the expression of KLK5, KLK10, KLK13 and KLK14 in testicular cancer and their possible roles during testicular cancer development, as well as their clinical applications are briefly reviewed. | Human | KLK6 | 5653 | kallikrein-related peptidase 6 | For example, hK4, hK5, hK6, hK7, hK8, hK10, hK11, hK13 and hK14 are emerging biomarkers for ovarian, breast, prostate and testicular cancer. For example, hK4, hK5, hK6, hK7, hK8, hK10, hK11, hK13 and hK14 are emerging biomarkers for ovarian, breast, prostate and testicular cancer. | Human | NKX3-1 | 4824 | | Here we show that NKX3.1 expression is dramatically down-regulated in testicular cancer of germ cell origin. |
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