Mouse | JDP2 | 122953 | Jun dimerization protein 2 | Using cell transformation assays in NIH3T3 cells and injection of prostate cancer cell lines overexpressing JDP2 into severe combined immuno-deficient (SCID) mice, we show for the first time the potential role of JDP2 in inhibition of cell transformation and tumor suppression. |
Mouse | WFDC1 | 58189 | WAP four-disulfide core domain 1 | Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. |
Mouse | AZIN1 | 51582 | antizyme inhibitor 1 | Overexpression of antizyme inhibitor in NIH-3T3 mouse fibroblasts or in AT2.1 Dunning rat prostate carcinoma cells resulted in an increased rate of cell proliferation and an increase in saturation density of the cultured cells. |
Mouse | CDC37 | 11140 | cell division cycle 37 | These data suggest that the expression of Cdc37 may promote inappropriate proliferation and may be an important early step in the development of human prostate cancer. |
Mouse | GLIPR1 | 11010 | GLI pathogenesis-related 1 | We previously identified the mouse RTVP-1 (mRTVP-1; related to testes-specific, vespid, and pathogenesis proteins) gene as a direct target of p53 with proapoptotic activities in various cancer cell lines, including prostate cancer. We previously identified and characterized a novel p53-regulated gene in mouse prostate cancer cells that was homologous to a human gene that had been identified in brain cancers and termed RTVP-1 or GLIPR. |
Mouse | AKAP12 | 9590 | A kinase (PRKA) anchor protein 12 | SSeCKS, a Src-suppressed protein kinase C substrate with metastasis suppressor activity, is the rodent orthologue of human gravin/AKAP12, a scaffolding protein for protein kinase A and protein kinase C. We show here that the tetracycline-regulated reexpression of SSeCKS in MatLyLu (MLL) prostate cancer cells suppressed formation of macroscopic lung metastases in both spontaneous and experimental models of in vivo metastasis while having minimal inhibitory effects on the growth of primary-site s.c. tumors. SSeCKS, a major protein kinase C substrate with tumor suppressor activity, is likely the rodent orthologue of human Gravin/AKAP12, a scaffolding protein for protein kinases A and C. Gravin was mapped as a single-copy gene to 6q24-25.2, a hotspot for deletion in advanced prostate cancer, and therefore, we investigated the role of SSeCKS/Gravin in prostate oncogenesis. |
Mouse | TNFRSF11A | 8792 | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | Click here to display 3 evidence detail records. |
Mouse | TP53BP1 | 7158 | tumor protein p53 binding protein 1 | We previously showed that ectopic expression of p202 in human prostate cancer cells renders growth inhibition and suppression of transformation phenotype in vitro. In this report, we showed that prostate cancer cells with stable expression of p202 were less tumorigenic than the parental cells. |
Mouse | TNFAIP6 | 7130 | tumor necrosis factor, alpha-induced protein 6 | TSG-6 was low or undetectable in prostate cancer cells (LNCaP, PC-3, and DU145) and TRAMP tumors but up-regulated in response to 2-methoxyestradiol. |
Mouse | TGFB3 | 7043 | transforming growth factor, beta 3 | Northern blotting showed that mRNA levels for the four growth-related genes transforming growth factor-beta 1 (TGF-beta 1), transforming growth factor-beta 3 (TGF-beta 3), tissue-type plasminogen activator (tPA), and c-myc were significantly elevated in clonal mouse prostate carcinomas grown in castrated hosts. |
Mouse | STAT5B | 6777 | signal transducer and activator of transcription 5B | These results support our hypothesis that specific activation of STAT5, in particular STAT5B, facilitates the progression of prostate cancer. |
Mouse | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Activation of Stat3 in androgen-sensitive LNCaP prostate cancer cells results in enhancement of tumor growth in both intact and castrated male nude mice and enhances androgen receptor-mediated prostate specific antigen expression. CONCLUSIONS: These findings demonstrate that intracellular signaling mediated by Stat3 can enhance the growth of androgen-sensitive human LNCaP prostate cancer cells in both intact and castrated male nude mice. |
Mouse | S100A4 | 6275 | S100 calcium binding protein A4 | Click here to display 6 evidence detail records. |
Mouse | RORA | 6095 | RAR-related orphan receptor A | Click here to display 3 evidence detail records. |
Mouse | PRSS8 | 5652 | protease, serine, 8 | Prostasin mRNA expression was absent in invasive prostate cancer cell lines of a transgenic mouse model. |
Mouse | MAPK9 | 5601 | mitogen-activated protein kinase 9 | Moreover, systemic treatment of mice bearing established xenografts of PC3 prostate carcinoma cells with antisense JNK1 and JNK2 led to inhibition tumor growth by 57% (P < 0.002) and 80% (P < 0.001), respectively. CONCLUSION: These results indicate that JNK is required for growth of prostate carcinoma cells in vitro and in vivo, and additionally indicate that JNK2 plays a dominant role. |
Mouse | PEBP1 | 5037 | phosphatidylethanolamine binding protein 1 | RESULTS: Clinical samples of primary prostate cancer had detectable RKIP expression, whereas clinical samples of prostate cancer metastases did not. |
Mouse | NKX3-1 | 4824 | | Click here to display 5 evidence detail records. |
Mouse | MSMB | 4477 | microseminoprotein, beta- | Prostate targeting: PSP94 gene promoter/enhancer region directed prostate tissue-specific expression in a transgenic mouse prostate cancer model. |
Mouse | MCM7 | 4176 | minichromosome maintenance complex component 7 | These studies implicate MCM7, and the DNA replication licensing gene family, in prostate cancer progression, growth and invasion. |
Mouse | KDR | 3791 | kinase insert domain receptor (a type III receptor tyrosine kinase) | Click here to display 3 evidence detail records. |
Mouse | JUNB | 3726 | jun B proto-oncogene | Western blotting analysis showed that an absence of wild-type p53, and/or a loss of junB and AP2 protein expression, correlated with downregulation of KAI1 mRNA levels in a series of prostate cancer cell lines. |
Mouse | JUN | 3725 | jun proto-oncogene | Antitumor mechanisms of oligodeoxynucleotides with CpG and polyG motifs in murine prostate cancer cells: decrease of NF-kappaB and AP-1 binding activities and induction of apoptosis. Further studies using Western blot analysis and electrophoresis mobility shift assay (EMSA) revealed that the treatment of prostate cancer cells with specific ODNs activated the caspase pathway(s) and decreased the binding activities of AP-1 and NF-kappaB in a time-dependent manner. |
Mouse | IGFBP5 | 3488 | insulin-like growth factor binding protein 5 | Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models. These findings suggest that up-regulation of IGFBP-5 after castration serves to enhance IGF bioactivity and raise the possibility that the response of prostate cancer to androgen withdrawal can be enhanced by strategies, such as antisense IGFBP-5 ODN therapy, that target IGF signal transduction. |
Mouse | IGFBP3 | 3486 | insulin-like growth factor binding protein 3 | In this study, we report that IGF-binding protein (IGFBP)-3 transcripts (that regulate levels of free IGF) are down-regulated in prostate cancer cells cocultured with PMO, whereas prostate-specific antigen (a protease known to cleave IGFBP-3) is detected in the 150-400 ng/ml range. |