Human | CXCL16 | 58191 | chemokine (C-X-C motif) ligand 16 | Hyperhomocysteinemia up-regulates CXCL16 leading to increased recruitment of CXCR6(+) lymphocytes and scavenging of modified lipids via a potential involvement of a PPAR-gamma-dependent mechanism |
Human | BHMT2 | 23743 | betaine--homocysteine S-methyltransferase 2 | Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism |
Human | CXCR6 | 10663 | chemokine (C-X-C motif) receptor 6 | Hyperhomocysteinemia up-regulates CXCL16 leading to increased recruitment of CXCR6(+) lymphocytes and scavenging of modified lipids via a potential involvement of a PPAR-gamma-dependent mechanism |
Human | VEGFA | 7422 | vascular endothelial growth factor A | Our findings suggest that hyperhomocysteinemia could promote the development of atherosclerotic lesions through VEGF induction in macrophages |
Human | TYMS | 7298 | thymidylate synthetase | Title:The role of genetic factors in the development of hyperhomocysteinemia.|Association:Not Found|Conclusion:In conclusion, the study on vegetarians and seniors documents interesting lifestyle-genotype interactions. Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation. |
Human | TPMT | 7172 | thiopurine S-methyltransferase | Defective methylation and subsequent hyperhomocysteinemia leading to impairment of thiopurine methyltransferase activity may serve as a MS susceptibility factor |
Human | TGFB1 | 7040 | transforming growth factor, beta 1 | TGFB expression is not affected by hyperhomocysteinaemia either in normal or in high glucose in fibroblasts |
Human | TCN2 | 6948 | transcobalamin II | The results, if confirmed in other populations, highlight the necessity for investigation of the transcobalamin II C776G polymorphism in the research for hyperhomocysteinemia risk factors |
Human | TCN1 | 6947 | transcobalamin I (vitamin B12 binding protein, R binder family) | Title:The role of genetic factors in the development of hyperhomocysteinemia.|Association:Not Found|Conclusion:In conclusion, the study on vegetarians and seniors documents interesting lifestyle-genotype interactions. Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease |
Human | SREBF1 | 6720 | sterol regulatory element binding transcription factor 1 | SREBP-1c could participate to the hepatic steatosis observed in humans and related to alcohol consumption and hyperhomocysteinaemia, two pathologies which are concomitant with a stress of the endoplasmic reticulum and an insulin activation |
Human | SHMT1 | 6470 | serine hydroxymethyltransferase 1 (soluble) | Title:The role of genetic factors in the development of hyperhomocysteinemia.|Association:Not Found|Conclusion:In conclusion, the study on vegetarians and seniors documents interesting lifestyle-genotype interactions. Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation. |
Human | PROC | 5624 | protein C (inactivator of coagulation factors Va and VIIIa) | activation of protein C by thrombin and inactivation of plasma FVa by APC are not impaired in human volunteers with acute hyperhomocysteinemia |
Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | NO concentration but not the polymorphism of MTHFR and eNOS gene and hyperhomocysteinemia are associated with recurrent pregnancy loss in Japanese |
Human | MTRR | 4552 | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | study evaluated the importance of the polymorphisms in the MTHFR, MTRR, and CBS genes for hyperhomocysteinemia, considering B12 and folate levels; results confirm that genetic interactions can influence on the homocysteine status No differences in mean homocysteine, prevalence of hyperhomocysteinemia and significant coronary artery disease between genotypes AA, AG, GG |
Human | MTR | 4548 | 5-methyltetrahydrofolate-homocysteine methyltransferase | Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L |
Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Click here to display 35 evidence detail records. |
Human | FOLR1 | 2348 | folate receptor 1 (adult) | Mutations in the 5'-untranslated region and proximal promoter of the folate receptor-alpha (FR-alpha) gene could be a new factor contributing to gene-food interaction explaining part of the hyperhomocysteinemia panorama |
Human | FOLH1 | 2346 | folate hydrolase (prostate-specific membrane antigen) 1 | Title:Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia.|Association:Y|Conclusion:These data suggest that the presence of the H475Y GCPII allele impairs the intestinal absorption of dietary folates, resulting in relatively low blood folate levels and consequent hyperhomocysteinemia. |
Human | F5 | 2153 | coagulation factor V (proaccelerin, labile factor) | inactivation of plasma FVa by APC is not impaired in human volunteers with acute hyperhomocysteinemia |
Human | ACE | 1636 | angiotensin I converting enzyme | An effective risk factor was found when the polymorphisms of the ACE genes= and hyperhomocysteinemia were associated with risk of chronic kidnen allograft dysfunction |
Human | COMT | 1312 | catechol-O-methyltransferase | Title:The role of genetic factors in the development of hyperhomocysteinemia.|Association:Not Found|Conclusion:In conclusion, the study on vegetarians and seniors documents interesting lifestyle-genotype interactions. Although the TC and COMT mutations influence cellular vitamin B12 metabolism, this effect did not result in overt homocysteine elevation. |
Human | CBS | 875 | cystathionine-beta-synthase | study evaluated the importance of the polymorphisms in the MTHFR, MTRR, and CBS genes for hyperhomocysteinemia, considering B12 and folate levels; results confirm that genetic interactions can influence on the homocysteine status plasma Hcy-thiolactone is elevated 59-fold and 72-fold in human patients with hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase and cystathionine beta-synthase genes, respectively |
Human | BHMT | 635 | betaine--homocysteine S-methyltransferase | betaine-homocysteine methyltransferase (BHMT) transgenic mice are resistant to alcohol or high methionine low folate diet -induced hyperhomocysteinemia and liver steatosis |
Human | ATF3 | 467 | activating transcription factor 3 | role of JNK-ATF3 pathway in apoptosis of vascular endothelial cells associated with hyperhomocysteinemia |
Human | APOE | 348 | apolipoprotein E | The ApoE4 allele constitutes a risk factor for hippocampal volume loss in patients with alcohol dependence under the conditions of hyperhomocysteinemia |