Human | LOC100507436 | 100507436 | | 1)MICA expressed in the M8 melanoma cell line triggered NK cell tumor lysis and 2)HLA-G1 coexpression mediated the inhibition of NK cytotoxicity by mitigating the MICA activating signal upregulation of MICA and MICB by treatment with TsA leads to enhancement of the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells |
Human | NCR3 | 259197 | natural cytotoxicity triggering receptor 3 | Shown that NKp30-immunoglobulin recombinant fusion protein is Duffy binding-like proteins, natural cytotoxicity receptors are involved in naturual killer cell-Plasmodium- parasitized erythrocytes NKp30, among natural cytotoxicity receptors, appeared to be primarily involved in triggering NK cells upon interaction with bone marrow stromal cells Selective cross-talk among natural cytotoxicity receptors (NKp46, NKp30 and NKp44) in human natural killer cells |
Human | RAET1E | 135250 | retinoic acid early transcript 1E | immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D-mediated NK cell cytotoxicity to tumors |
Human | SH2D1B | 117157 | SH2 domain containing 1B | NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2 |
Human | SLAMF6 | 114836 | SLAM family member 6 | blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2 |
Human | REPS1 | 85021 | RALBP1 associated Eps domain containing 1 | Inhibition of RALBP1 by polyclonal antibodies causes increased drug-accumulation and increased cytotoxicity which demonstrate the potential utility of targeting RALBP1 in the treatment of leukemia |
Human | NT5C1A | 84618 | 5'-nucleotidase, cytosolic IA | overexpression of 5'-nucleotidase inhibits Natural Killer cell cytotoxicity to ameliorate rejection after xenotransplantation |
Human | SLC39A8 | 64116 | solute carrier family 39 (zinc transporter), member 8 | These data are the first to characterize human SLC39A8 (Zip8) and remarkably demonstrate that upregulation of Zip8 is sufficient to protect lung epithelia against TNF-alpha-induced cytotoxicity |
Human | SLAMF7 | 57823 | SLAM family member 7 | blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity |
Human | AS3MT | 57412 | arsenic (+3 oxidation state) methyltransferase | Heterologous expression of rat AS3MT in human urothelial cells...confers capacity to methylate inorganic arsenic and alters its cytotoxicity and that of methylated arsenicals |
Human | EXOSC5 | 56915 | exosome component 5 | These results in our study indicates gene silencing of SOCS1 remarkably enhanced the cytotoxicity efficiency of CML28 DNA vaccine in DCs |
Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | In HL cells, grzB-induced mitochondrial release of proapoptotic Smac is blocked, which results in complete abrogation of cytotoxicity mediated by CTLs |
Human | DEFB103B | 55894 | defensin, beta 103B | results demonstrate that antimicrobial activity & absence of cytotoxicity can be explained by lipid-specificity of hBD3; clear correlation between these aspects of biological activity of hBD3 & its interaction with lipid matrices could be found |
Human | CD244 | 51744 | CD244 molecule, natural killer cell receptor 2B4 | blocking the engagement of 2B4, NTB-A and CRACC has no effect on the proliferation or development of the cytotoxic potential of NK cells but triggering by their physiological ligands on MHC class I-negative target cells induces potent NK cell cytotoxicity 2B4 (CD244) can stimulate NK cell cytotoxicity and cytokine production by interacting with NK cell expressed CD48 and adds CD48 to the growing number of activating NK cell receptors The lower surface expression of 2B4 after ligand-induced down-modulation results in reduced 2B4-mediated NK cell activation and cytotoxicity The triggering of 2B4 (CD244) alone is sufficient to induce natural killer (NK) cell cytotoxicity in IL-2-activated NK cells with high SLAM-associated protein expression |
Human | DCPS | 28960 | decapping enzyme, scavenger | Furthermore, we show that a novel human histidine triad protein DCS-1, which is expressed together with NR1 in many tissues, can significantly reduce menadione-induced cytotoxicity in these cells |
Human | RNF19A | 25897 | ring finger protein 19A, E3 ubiquitin protein ligase | results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 |
Human | KLRK1 | 22914 | killer cell lectin-like receptor subfamily K, member 1 | Click here to display 8 evidence detail records. |
Human | RALBP1 | 10928 | ralA binding protein 1 | RLIP76 has a role in triggering apoptosis in lung cancer cells and synergistically increaseing doxorubicin cytotoxicity |
Human | CXCL13 | 10563 | chemokine (C-X-C motif) ligand 13 | CCL19 plus CXCL13 regulate interaction between B-ALL CD23+CD5+ B cells and CD8+ T cells by inducing activation of PEG10, in turn, resulting in IL-10 overexpression and impairment of tumor-specific cytotoxicity in syngeneic CD8+ T cells |
Human | CD96 | 10225 | CD96 molecule | CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR), stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells |
Human | SNCAIP | 9627 | synuclein, alpha interacting protein | results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 |
Human | NCR1 | 9437 | natural cytotoxicity triggering receptor 1 | natural cytotoxicity receptor (NCR) and NK receptor member D of the lectin-like receptor family (NKG2D) were the key NK activating receptors for bone marrow-derived myeloma cell recognition |
Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | Recombinant adiponectin suppresses IL-2-induced natural killer cell cytotoxicity by inhibiting the NF-kappa B signaling pathway and downregulating interferon-gamma |
Human | TRIP10 | 9322 | thyroid hormone receptor interactor 10 | CIP4 is an important cytoskeletal adaptor that functions after filamentous actin accumulation and Cdc42 activation to enable microtubule organizing center polarization and NK cell cytotoxicity |
Human | SLC28A2 | 9153 | solute carrier family 28 (concentrative nucleoside transporter), member 2 | Human nucleoside transporters involved in cellular uptake of Bbenzamide riboside and tiazofurin and their role in cytotoxicity |