Mouse | WNT3A | 89780 | wingless-type MMTV integration site family, member 3A | WNT3 and WNT3A genes are two human paralogues of mouse proto-oncogene Wnt3, which induces carcinogenesis through activation of the beta-catenin - TCF signaling pathway. |
Mouse | DNAJC12 | 56521 | DnaJ (Hsp40) homolog, subfamily C, member 12 | The 11 up-regulated genes included 7 carcinogenesis-related genes (Igfbp1, Tff3, Hpx, Orm2, Ctsl, Plg, Jdp1), and the 9 down-regulated genes included Car3 that is associated with the protection of cells from attack by oxygen radicals. |
Mouse | LY6D | 8581 | lymphocyte antigen 6 complex, locus D | In conclusion, these results identify distinguishing features between non-genotoxic and genotoxic carcinogen derived liver tumors as well as genes that are upregulated in both types and suggest that RIKEN cDNA, Ly-6D and lipocalin 2 in particular appear to be desirable molecular markers for further study in liver carcinogenesis and progression. |
Mouse | UBC | 7316 | ubiquitin C | Recent work has shown that peroxisome proliferator-activated receptor beta (PPARbeta) attenuates cell proliferation and skin carcinogenesis, and this is due in part to regulation of ubiquitin C expression. Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. |
Mouse | THBS2 | 7058 | thrombospondin 2 | Click here to display 3 evidence detail records. |
Mouse | TBX3 | 6926 | T-box 3 | The closely related T-box genes Tbx2 and Tbx3 are both expressed in the developing mammary glands of mouse embryos and both have been implicated in mammary carcinogenesis. |
Mouse | TBX2 | 6909 | T-box 2 | The closely related T-box genes Tbx2 and Tbx3 are both expressed in the developing mammary glands of mouse embryos and both have been implicated in mammary carcinogenesis. |
Mouse | PTGER3 | 5733 | prostaglandin E receptor 3 (subtype EP3) | Prostaglandin E receptor EP3 deficiency modifies tumor outcome in mouse two-stage skin carcinogenesis. Unlike EP3 knockout mice, the EP2 knockout mice produced significantly fewer tumors and reduced tumor incidence compared with wild type (WT) mice in a 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) two-stage carcinogenesis protocol. |
Mouse | KLK6 | 5653 | kallikrein-related peptidase 6 | By monitoring BSSP expression throughout experimental skin carcinogenesis we found strong constitutive expression in hyperplastic epidermis as well as in proliferatively active keratinocytes of benign and malignant skin tumors. Keratinocyte-specific onset of serine protease BSSP expression in experimental carcinogenesis. |
Mouse | PPARD | 5467 | peroxisome proliferator-activated receptor delta | Click here to display 6 evidence detail records. |
Mouse | PMS2 | 5395 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | These results suggest that a single normal PMS2 allele can protect thymus but not intestine from MNU carcinogenesis. |
Mouse | NOTCH1 | 4851 | notch 1 | Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis. |
Mouse | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | CONCLUSIONS: The lack of NM23-M1 expression promotes metastasis in the SV40 animal model of liver carcinogenesis. |
Mouse | NKX3-1 | 4824 | | Click here to display 8 evidence detail records. |
Mouse | NFATC4 | 4776 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | These findings suggest that NFAT3/cyclooxygenase-2 act as a link between inflammation and carcinogenesis by being involved in the tumor promotion stage. |
Mouse | FGFR4 | 2264 | fibroblast growth factor receptor 4 | Fibroblast growth factor receptor 4, implicated in progression of islet cell carcinogenesis by its expression profile, does not contribute functionally. |
Mouse | EPHA2 | 1969 | EPH receptor A2 | We report here that deletion of EphA2 in mouse led to markedly enhanced susceptibility to 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA) two-stage skin carcinogenesis. Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. |
Mouse | CTSE | 1510 | cathepsin E | In contrast to previous reports suggesting that activation of PPARbeta potentiates intestinal tumorigenesis, here we show that ligand activation of PPARbeta attenuates chemically induced colon carcinogenesis and that PPARbeta-dependent induction of cathepsin E could explain the reported disparity in the literature about the effect of ligand activation of PPARbeta in the intestine. |
Human | CD24 | 100133941 | CD24 molecule | As a putative new oncogene that is overexpressed in gastrointestinal malignancies early in the carcinogenesis process, CD24 my be a potential target for early intervention in the prevention and treatment of cancer |
Human | HEPN1 | 641654 | hepatocellular carcinoma, down-regulated 1 | CONCLUSIONS: Our data show that HEPN1 is frequently silenced in HCC, and that exogenous HEPN1 exhibits antiproliferative effect on HepG2 cells, suggesting that silencing of HEPN1 may be associated with carcinogenesis of hepatocytes. |
Human | KLKP1 | 606293 | kallikrein pseudogene 1 | KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that may play a role in prostate carcinogenesis or maintenance CONCLUSIONS: KLK31P is a novel androgen regulated and transcribed pseudogene of kallikreins that may play a role in prostate carcinogenesis or maintenance. |
Human | STGC3 | 474171 | uncharacterized STGC3 | Results suggest that an abnormality in STGC3 expression is associated with nasopharyngeal carcinogenesis and that it may play an important role in controlling cell growth and regulating the cell cycle |
Human | MIR197 | 406974 | microRNA 197 | CONCLUSIONS: Our observations show that miR-197 and miR-346 contribute to FTC carcinogenesis. |
Human | MIR126 | 406913 | microRNA 126 | miR-126 regulates PI3K signaling partly by targeting p85beta, and loss of miR-126 may provide a selective growth advantage during colon carcinogenesis miR-126 regulates PI3K signaling partly by targeting p85beta, and that the loss of miR-126 may provide a selective growth advantage during colon carcinogenesis |
Human | MIR1-1 | 406904 | | Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis |