Human | RACGAP1 | 29127 | Rac GTPase activating protein 1 | intracellular Ca2+ is mobilized by sphingosine 1 phosphate and mediates rac activation and adherens junction assembly in endothelial cells |
Human | HPSE | 10855 | heparanase | heparanase plays a unique dual role in tumor metastasis, facilitating tumor cell invasiveness and inducing VEGF C expression, thereby increasing the density of lymphatic vessels that mobilize metastatic cells |
Human | NEU3 | 10825 | sialidase 3 (membrane sialidase) | NEU3 is able to mobilize to membrane ruffles in response to growth stimuli and activate the Rac-1 signaling by co-localization with Rac-1, leading to increased cell motility |
Human | CXCR4 | 7852 | chemokine (C-X-C motif) receptor 4 | by down-regulating neutrophil CXCR4 expression and attenuating neutrophil responsiveness to SDF-1, lipopolysaccharide can mobilize neutrophils from bone marrow to the peripheral blood through reducing neutrophil retention in bone marrow L-selectin mobilized intracellular CXCR4 to significantly increase surface CXCR4 stimulation, inhibited SDF-1 induced CXCR4 internalization, increased SDF-1-induced lymphocyte adhesion and transendothelial migration |
Human | VEGFC | 7424 | vascular endothelial growth factor C | heparanase plays a unique dual role in tumor metastasis, facilitating tumor cell invasiveness and inducing VEGF C expression, thereby increasing the density of lymphatic vessels that mobilize metastatic cells |
Human | TP53 | 7157 | tumor protein p53 | These data indicate a novel p53-dependent mechanism in which cell stress mobilizes nucleolin for transient replication inhibition and DNA repair |
Human | TLR5 | 7100 | toll-like receptor 5 | Toll-like receptor (TLR)5 is stored intracellularly in neutrophils and is mobilized to the cell surface in a protein synthesis-independent manner after stimulation with TLR ligands and cytokines characteristic of cystic fibrosis airway microenvironment |
Human | STAT3 | 6774 | signal transducer and activator of transcription 3 (acute-phase response factor) | Hematopoietic CD34+ cells secreted IL-15 that, through autocrine/paracrine loop distinct signal pathways, activated NF-kB in bone marrow and cord blood progenitors, and activated STAT3 and STAT5 in peripheral G-CSF-mobilized and BM progenitors only |
Human | SLC2A4 | 6517 | solute carrier family 2 (facilitated glucose transporter), member 4 | TUG traps endocytosed GLUT4 and tethers it intracellularly, and insulin mobilizes this pool of retained GLUT4 by releasing this tether |
Human | SELL | 6402 | selectin L | L-selectin mobilized intracellular CXCR4 to significantly increase surface CXCR4 stimulation and inhibited SDF-1 induced CXCR4 internalization |
Human | CXCL12 | 6387 | chemokine (C-X-C motif) ligand 12 | Since we demonstrated that not only SDF-1, but also HGF and LIF are upregulated in damaged tissues, we postulate that CXCR4+ c-Met+ LIF-R+ TCSC could be mobilized from the BM into the PB, where they play a role in tissue repair/regeneration |
Human | RAB27A | 5873 | RAB27A, member RAS oncogene family | Rab27a is a major component of the exocytic machinery of human neutrophils, modulating the secretion of tertiary and specific granules that are readily mobilized upon neutrophil activation |
Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Data show that prostag;andins E2 and F2alpha can mobilize inositol 1,4,5-trisphosphate, induce ERK1/2 phosphorylation and induce cyclooxygenase-2 expression via the FP receptor |
Human | PRTN3 | 5657 | proteinase 3 | PR3 originates from two distinct pools, the granular pool mobilized following degranulation or a plasma membrane pool mobilized upon apoptosis |
Human | PRODH | 5625 | proline dehydrogenase (oxidase) 1 | proline oxidase mediates apoptosis through the generation of proline-dependent ROS, which then mobilize calcium and activate calcineurin |
Human | PLAU | 5328 | plasminogen activator, urokinase | Substitution of the two relevant serines with glutamic acid residues impairs the ability of urokinase to mobilize a variety of human and mouse cell lines as well as human primary T lymphocytes |
Human | KLRD1 | 3824 | killer cell lectin-like receptor subfamily D, member 1 | Expression of the inhibitory NKR (CD94/NKG2A) of the G-CSF mobilized peripheral blood mononuclear cells |
Human | ITGB4 | 3691 | integrin, beta 4 | alpha6beta4 integrin is mobilized and activated durign carcinoma progression [review] |
Human | ITGA6 | 3655 | integrin, alpha 6 | alpha6beta4 integrin is mobilized and activated durign carcinoma progression [review] |
Human | IL13 | 3596 | interleukin 13 | CC chemokine receptor 3 mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of this protein |
Human | IL6 | 3569 | interleukin 6 (interferon, beta 2) | capacity of bladder cells to mobilize secondary messengers and evoke a more rapid IL-6 response via TLR4 protein might be critical in their role as first responders to microbial challenge |
Human | FLT1 | 2321 | fms-related tyrosine kinase 1 | Bone marrow-derived cells expressing this gene can be mobilized into and cluster at distant sites, "the premetastatic niche" |
Human | CSF3 | 1440 | colony stimulating factor 3 (granulocyte) | monocytes mobilized into the blood by G-CSF or AMD3100 stimulate angiogenesis at sites of ischemia through a paracrine mechanism G-CSF mobilizes CD34+ cells, increases hepatocyte growth factor, and induces hepatic progenitor cells to proliferate within 7 days of administration |
Human | CCR3 | 1232 | chemokine (C-C motif) receptor 3 | This protein mobilizes to the surface of human mast cells and potentiates immunoglobulin E-dependent generation of interleukin 13 |
Human | CDK1 | 983 | cyclin-dependent kinase 1 | mediates phosphorylation and mobilizes microtubule-organizing centers from the apical intermediate filament scaffold in CACO-2 epithelial cells |