Mouse | BEX2 | 84707 | brain expressed X-linked 2 | Genome-Wide Analysis of Epigenetic Silencing Identifies BEX1 and BEX2 as Candidate Tumor Suppressor Genes in Malignant Glioma. |
Mouse | RAG2 | 5897 | recombination activating gene 2 | Here, we show that intratumoral administration of Delta9-tetrahydrocannabinol and the synthetic cannabinoid agonist WIN-55,212-2 induced a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2. |
Mouse | RAD51 | 5888 | RAD51 recombinase | In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene. These results suggest that inhibition of RAD51 can be expected to serve as a novel potentiator for radiation therapy in malignant gliomas by inhibiting DNA double-strand break repair. |
Mouse | MDM4 | 4194 | Mdm4 p53 binding protein homolog (mouse) | We previously reported on the amplification and overexpression of the mouse double minute 4 homolog gene (MDM4) from 1q32 in a subset of malignant gliomas (Riemenschneider et al., Cancer Res 1999;59:6091-6). |
Mouse | MDK | 4192 | midkine (neurite growth-promoting factor 2) | Midkine promoter-based conditionally replicative adenovirus for malignant glioma therapy. |
Mouse | IL13 | 3596 | interleukin 13 | In addition, we have reported that IL-13 cytotoxin, comprised of human IL-13 and a mutated form of Pseudomonas exotoxin, is highly and specifically cytotoxic to these cells and can lead to pronounced antitumor activity in malignant glioma tumors in animal models. |
Human | LOC732093 | 732093 | | an association between Hsc70 and ASIC2 that may underlie the increased retention of ASIC2 in the endoplasmic reticulum of glioma cells |
Human | GGT2 | 728441 | gamma-glutamyltransferase 2 | Since GGT expression and its role in malignant glioma biology remain largely unknown, we investigated this phenomenon by immunostaining 26 higher-grade human astrocytic gliomas (WHO grades III and IV) with a monoclonal anti-GGT-antibody (138H11). |
Human | MIR21 | 406991 | microRNA 21 | miR-21 contributes to glioma malignancy by downregulation of matrix metalloproteinases (MMP) inhibitors, which leads to activation of MMPs, thus promoting invasiveness of cancer cells |
Human | ASPM | 259266 | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | Increase in ASPM mRNA and protein expression is associated with malignant gliomas |
Human | NEWENTRY | 192343 | Record to support submission of GeneRIFs for a gene not in Gene (human; man). | Both integrins, v3 and v5, are involved in the glioma cell radioresistance through the integrin-linked kinase (ILK) and the small GTPase RhoB, at least by regulating the radiation-induced mitotic cell death (rhoB GTP-Binding Protein) |
Human | TMEM18 | 129787 | transmembrane protein 18 | Overexpression of TMEM18 is associated with glioma |
Human | MTDH | 92140 | metadherin | AEG-1 might function as a coactivator for NF-kappaB, consequently augmenting expression of genes necessary for invasion of glioma cells |
Human | BEX2 | 84707 | brain expressed X-linked 2 | Two novel brain expressed genes, BEX1 and BEX2 are identified; they are silenced in all glioma specimens and exhibit extensive promoter hypermethylation |
Human | MAGED4B | 81557 | melanoma antigen family D, 4B | It has recently been demonstrated that malignant glioma cells express certain known tumor-associated antigens, such as HER-2, gp100, and MAGE-1. |
Human | SPHKAP | 80309 | SPHK1 interactor, AKAP domain containing | HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells |
Human | DUSP26 | 78986 | dual specificity phosphatase 26 (putative) | Downregulation of Dusp26 may contribute to malignant phenotypes of glioma |
Human | LRRC4 | 64101 | leucine rich repeat containing 4 | Methylation-mediated inactivation of LRRC4 is a frequent and glioma-specific event these studies represent the first cDNA array analysis of the effects of LRRC4 on the involvement of different neurobiological genes in U251MG glioblastoma cells and provide new insights into the function of LRRC4 in glioma |
Human | BCAN | 63827 | brevican | The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican |
Human | DIABLO | 56616 | diablo, IAP-binding mitochondrial protein | Most importantly, Smac peptides strongly enhanced the antitumor activity of Apo-2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in an intracranial malignant glioma xenograft model in vivo. Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo. Data show that transfer of the gene encoding Smac sensitized tumor and malignant glioma cells for apoptosis, and that Smac peptides enhanced the antitumor activity of Apo-2L/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) Here, we report that transfer of the gene encoding second mitochondria-derived activator of caspase (Smac) or Smac peptides sensitized various tumor cells in vitro and malignant glioma cells in vivo for apoptosis induced by death-receptor ligation or cytotoxic drugs. |
Human | BEX1 | 55859 | brain expressed, X-linked 1 | Genome-Wide Analysis of Epigenetic Silencing Identifies BEX1 and BEX2 as Candidate Tumor Suppressor Genes in Malignant Glioma. |
Human | PPIL3 | 53938 | peptidylprolyl isomerase (cyclophilin)-like 3 | The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma |
Human | SHC3 | 53358 | SHC (Src homology 2 domain containing) transforming protein 3 | Finally, we found that the expression of truncated variants of Shc3 with dominant-negative effects in human high-grade glioma cells that maintain Shc3 expression in vitro leads to a decreased Akt posphorylation and increased apoptosis, thus resulting in impaired survival of the transfected cells. The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells |
Human | ACSL5 | 51703 | acyl-CoA synthetase long-chain family member 5 | These results indicate that ACSL5 is a critical factor for survival of glioma cells under acidic tumor microenvironment |
Human | TNFRSF12A | 51330 | tumor necrosis factor receptor superfamily, member 12A | up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors |