Human | PTBP2 | 58155 | polypyrimidine tract binding protein 2 | Overexpression of PTB in resting CD4+ T cells from patients on highly active antiretroviral therapy (HAART) allowed cytoplasmic accumulation of HIV-1 RNAs |
Human | HDAC7 | 51564 | histone deacetylase 7 | VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating MT-MMP1/MMP10 expression and angiogenesis |
Human | TARDBP | 23435 | TAR DNA binding protein | Neuropathological examination reveals cytoplasmic deposition of the TDP-43 protein in affected pedigree members with frontotemporal lobar degeneration--motor neuron disease |
Human | FOSL1 | 8061 | FOS-like antigen 1 | Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis |
Human | ZFP36 | 7538 | ZFP36 ring finger protein | HSV-1 virion host shutoff protein dependent degradation of AU-rich element-containing RNAs correlates with the transactivation, cytoplasmic accumulation, and persistence of tristetraprolin in infected cells |
Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | Reconstitution of VHL expression in renal cell carcinoma (RCC) cells repressed hepatocyte growth factor (HGF)-stimulated beta-catenin tyrosyl phosphorylation, cytoplasmic beta-catenin accumulation, and reporter gene transactivation |
Human | SMARCB1 | 6598 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | INI1 is dispensable for retrovirus-induced cytoplasmic accumulation of PML and does not interfere with virus integration |
Human | PLAUR | 5329 | plasminogen activator, urokinase receptor | urokinase and urokinase receptor mRNAs are stabilized by HuR linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2 |
Human | PLAU | 5328 | plasminogen activator, urokinase | urokinase and urokinase receptor mRNAs are stabilized by HuR linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2 |
Human | NPM1 | 4869 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | NPM1 gene mutations cause a frame shift in the C-terminus of exon 12, disrupting the NPM nucleolar-localization signal or generating a leucine-rich nuclear export motif, resulting in abnormal cytoplasmic accumulation of NPM NPM1 mutations in acute myeloid leukemia act to achieve maximum nuclear export and cytoplasmic accumulation of NPM1 COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants |
Human | KCNJ2 | 3759 | potassium inwardly-rectifying channel, subfamily J, member 2 | These results establish the direct regulation of Kir channels by the cytoplasmic accumulation of LC-CoA, which might be of physiological and pathophysiological relevance in a variety of tissues |
Human | IKBKB | 3551 | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | This novel finding indicated that IKKbeta could mediate cytoplasmic p21 accumulation via activation of its downstream target Akt, which was known to phosphorylate p21 and lead to cytoplasmic localization of p21 |
Human | ELAVL1 | 1994 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | Cytoplasmic accumulation of HUR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells |
Human | CTNND1 | 1500 | catenin (cadherin-associated protein), delta 1 | Overexpression of P-cadherin was strongly associated with cytoplasmic accumulation of one of the catenins, p120ctn, and cadherin switching in pancreatic ductal carcinoma cells |
Human | CTNNB1 | 1499 | catenin (cadherin-associated protein), beta 1, 88kDa | The cytoplasmic accumulation of beta-catenin is a common characteristic of oral SCC, but is not closely associated with mutational alterations in the APC, beta-catenin and Axin1 genes |
Human | ADAR | 103 | adenosine deaminase, RNA-specific | Results identify regions in human adenosine deaminase that acts on RNA (ADAR1) that interfere with nuclear localization and mediate cytoplasmic accumulation |