Human | TMPRSS6 | 164656 | transmembrane protease, serine 6 | Matriptase-2 suppresses breast tumor development in vivo, displays prognostic value for breast cancer patients, inhibits both breast cancer cell invasion and motility in vitro, and may play a contrasting role to matriptase-1 in breast cancer |
Human | CITED4 | 163732 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 | Results show that breast cancer development is characterized by either nuclear loss or cytoplasmic translocation of CITED4, with consequent loss of hypoxia-inducible factor-1alpha transcriptional antagonist activity |
Human | ITIH5 | 80760 | inter-alpha-trypsin inhibitor heavy chain family, member 5 | expression is consistantly lost or strongly downregulated in invasive ductal carcinoma; proposed that loss of ITIH5 expression may be involved in breast cancer development |
Human | LETMD1 | 25875 | LETM1 domain containing 1 | HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor |
Human | CHEK2 | 11200 | checkpoint kinase 2 | CHEK2 germline mutation rarely contributes to breast cancer development in the Czech Republic |
Human | PTGES3 | 10728 | prostaglandin E synthase 3 (cytosolic) | p23 differentially regulates ER target genes and is involved in the control of distinct cellular processes in breast tumor development |
Human | VAV3 | 10451 | vav 3 guanine nucleotide exchange factor | Findings suggest that Vav3 overexpression may aberrantly enhance ERalpha-mediated signaling axis and play a role in breast cancer development and/or progression |
Human | BCAS2 | 10286 | breast carcinoma amplified sequence 2 | This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function |
Human | NCOA3 | 8202 | nuclear receptor coactivator 3 | the N-terminally deleted isoform of AIB1 can play a role in breast cancer development and/or progression |
Human | WT1 | 7490 | Wilms tumor 1 | WT1 plays an important role in maintaining normal growth of mammary epithelial cells and dysregulated WT1 expression may contribute to breast cancer development |
Human | VDR | 7421 | vitamin D (1,25- dihydroxyvitamin D3) receptor | Title:Association of A vitamin D receptor polymorphism with sporadic breast cancer development.|Association:Y|Conclusion:Not Found |
Human | UBE2B | 7320 | ubiquitin-conjugating enzyme E2B | These data reveal a potentially important role for transcriptionally active beta-catenin in the regulation of Rad6B gene expression, and link aberrant beta-catenin signaling with transcriptional deregulation of Rad6B and breast cancer development |
Human | TP53 | 7157 | tumor protein p53 | results indicate that both BstUI and MspI p53 polymormphisms might play the role in the breast cancer development especially in women younger than 50 years |
Human | TERT | 7015 | telomerase reverse transcriptase | the MNS16A variant in the hTERT gene may contribute to the risk of breast cancer development and metastasis in Chinese women |
Human | AURKA | 6790 | aurora kinase A | Breast cancer development is driven by genomic instability associated with variant Aurora-A |
Human | SRD5A2 | 6716 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) | No breast development or menstruation at puberty |
Human | RPL7A | 6130 | ribosomal protein L7a | ethanol-induced alteration in expression may mediate the promoting effects of ethanol on breast cancer development |
Human | RAD51 | 5888 | RAD51 recombinase | alteration in RAD51 region may contribute to the disturbances of DNA repair involving RAD51 and/or BRCA2 penetration and thus enhance the risk of breast cancer development The obtained results indicate that alteration in the RAD51 region may contribute to the disturbances of DNA repair involving RAD51 and BRCA1 and thus enhance the risk of breast cancer development results suggest a contribution of BLM and RAD51 to breast cancer development and provide support for the tumorigenic significance of the functional interaction between these two HR proteins |
Human | PRKDC | 5591 | protein kinase, DNA-activated, catalytic polypeptide | role of DNA-PKcs in the processing of complex DNA damage and its potential association with breast cancer development |
Human | MKI67 | 4288 | antigen identified by monoclonal antibody Ki-67 | ER alpha and Ki67 might be involved in distinct pathological and molecular features during breast cancer development |
Human | LRP1 | 4035 | low density lipoprotein receptor-related protein 1 | The T allele of the C766T polymorphism in the LRP1 gene is associated with an increased risk of breast cancer development in women of Caucasian origin |
Human | IGF1 | 3479 | insulin-like growth factor 1 (somatomedin C) | GH1/IGF-1 axis polymorphisms may have a role in breast cancer development [review] |
Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | The only significant association between increased risk of breast cancer development and GSTs polymorphsims is found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 are combined |
Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | The only significant association between increased risk of breast cancer development and GSTs polymorphisms is found when GSTT1 null, GSTM1 null and the presence of valine in GSTP1 in codon 105 are combined |
Human | GH1 | 2688 | growth hormone 1 | GH1/IGF-1 axis polymorphisms may have a role in breast cancer development [review] |