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Genes (42)
Species: human : 42 | |
Human | LOC648998 | 648998 | | Overweight and obese adults demonstrate increased vascular endothelial expression of NAD(P)H oxidase-p47(phox) linked to oxidative stress | Human | LMO3 | 55885 | LIM domain only 3 (rhombotin-like 2) | The current findings have implications for treatment response to drugs currently in use (or being developed) for the treatment of overeating and overweight | Human | ITLN1 | 55600 | intelectin 1 (galactofuranose binding) | Omentin-1(ITLN1) is downregulated by insulin and glucose which may explain the decreased omentin-1 levels observed in our overweight women with polycystic ovary syndrome | Human | GHRL | 51738 | ghrelin/obestatin prepropeptide | Fasting total (acetylated and desacyl) ghrelin concentrations were lower in overweight (600 +/- 33 pg/ml) compared with normal weight (764 +/- 33 pg/ml, P < 0.05) boys and were not affected by exercise | Human | INSIG2 | 51141 | insulin induced gene 2 | There is no association of the rs7566605 variant with overweight in Japanese people There is a lack of association between single-nucleotide polymorphism rs7566605 and being overweight among the Japanese (in the middle-aged and elderly population) | Human | NMU | 10874 | neuromedin U | Amino acid variants in NMU associate with overweight and obesity, suggesting that NMU is involved in energy regulation in humans | Human | NAMPT | 10135 | nicotinamide phosphoribosyltransferase | Plasma visfatin levels are increased in overweight and obese subjects with metabolic syndrome | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | in overweight/obese Asians, the plasma adiponectin levels significantly correlated with various indices of metabolic syndrome except hypertension In overweight/obese postmenopausal women fat distribution does not affect adiponectin production Circulating adiponectin is associated with insulin resistance and HDL-C levels independent from body mass index in overweight subjects The SNP276G>T of the ADIPOQ gene is associated with different responses of circulating adiponectin and insulin resistance to mild weight loss in overweight-obese subjects study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans | Human | MGAM | 8972 | maltase-glucoamylase (alpha-glucosidase) | Acarbose has been found to improve insulin levels and thus glucose/insulin ratios more effectively in overweight patients compared with nonoverweight patients with PCOS | Human | UCP3 | 7352 | uncoupling protein 3 (mitochondrial, proton carrier) | Findings suggest a role of UCP2-UCP3 gene cluster haplotypes in diabetes; in particular, effects of the high-risk haplotypes were more apparent in overweight Caucasian women | Human | TNF | 7124 | tumor necrosis factor | 308A allele of the promoter of tumor necrosis factor-alpha gene is associated with high rates of glucose oxidation in normal weight subjects and with effective lipid storage in overweight subjects Promoter of the TNFalpha gene does not influence the amount of weight lost in overweight and obese men and women on a 30% energy restricted diet | Human | HNF1A | 6927 | HNF1 homeobox A | Coexistence of type 1 diabetes autoimmunity and a mutation in the gene for MODY3 in this overweight patient may explain the early onset of progressive insulinopenia compared with the later age of diabetes onset | Human | STX1A | 6804 | syntaxin 1A (brain) | A lower frequency of the PRM -352T allele of the STX1A gene in overweight/obese subjects impaires glucose regulation, particularly among individuals with combined glucose intolerance and overt diabetes | Human | SPP1 | 6696 | secreted phosphoprotein 1 | Plasma OPN and mRNA expression of OPN in omental adipose tissue are increased in overweight/obese patients | Human | SLC6A4 | 6532 | solute carrier family 6 (neurotransmitter transporter), member 4 | The S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity 5-HTTLPR polymorphism may be linked with BMI and also with obesity and/or overweight in adult male population, reinforcing the role of the serotonin transporter as a risk factor for the obesity phenotype | Human | ACSM3 | 6296 | acyl-CoA synthetase medium-chain family member 3 | variation in SAH has a role in predisposition to overweight in hypertensives | Human | PPARG | 5468 | peroxisome proliferator-activated receptor gamma | results provide further support of the association between the PPARG2 Ala12 allele and risk of overweight or obesity in Mestizos and two Amerindian populations from Mexico Regression analysis confirmed the association of the Pro12Ala mutation of the PPARgamma gene with normal but not with overweight/obesity among Type 2 diabetes patients PPARgamma amino acid sequencqe allele may confer protection against overweight in the Tunisian population | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | PAI-1 polymorphisms interact with known environmental risk factors (chronic hyperglycaemia, obesity, etc.) to induce a more severe insulin-resistant metabolic profile in overweight subjects, and to further increase risk for CHD in diabetic subjects | Human | NPY | 4852 | neuropeptide Y | The Leu7Pro polymorphism may be associated with dietary response to LDL-C concentration in overweight boys with a family history of early-onset CVD | Human | NMB | 4828 | neuromedin B | No significant differences in the genotype distribution were demonstrated between normal weight and overweight/obese subjects | Human | MTHFR | 4524 | methylenetetrahydrofolate reductase (NAD(P)H) | Finds no significant difference in the frequencies of MTHFR (C677T) gene polymorphism between the overweight/obese subjects and the control subjects | Human | MC4R | 4160 | melanocortin 4 receptor | The presence of heterozygous MC4R mutations in obese and overweight subjects indicates that these mutations may be a susceptibility factor for the development of obesity | Human | LIPC | 3990 | lipase, hepatic | hepatic lipase (LIPC)-514TT genotype and overweight status, when occurring together, were associated with a 3-fold increase in risk of preeclampsia among Peruvian women | Human | LEPR | 3953 | leptin receptor | There was a trend found among the majority of homozygous A and G variants in LEP -2548 G/A and LEPR 668 A/G in over-weight and obese individuals in comparison to normal-weight subjects (CG) | Human | LEP | 3952 | leptin | in obese women serum leptin level and the occurrence of binge eating are unrelated; relationship between serum leptin level and restraint of food intake observed in eating disordered patients and in overweight preadolescent girls is shared by obese women tendency for the majority of homozygous A and G variants in LEP -2548 G/A and LEPR 668 A/G was found in overweight and obese patients, in comparison to normal-weight subjects Title:|Association:Y|Conclusion:Not Found In overweight/obese postmenopausal women fat distribution does not affect leptin production; Leptin secretion is acutely regulated by glucose levels in insulin presence This study provides further evidence that IL-6, leptin, and adiponectin are associated with impaired fibrinolysis in overweight hypertensive humans that insulin resistance and the development of gallstones appears to be associated with serum leptin levels in subjects with overweight, but not in obese subjects with similar metabolic profiles |
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