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Genes (41)
Species:
human : 41 | |
| Human | STH | 246744 | saitohin | Increased risk of Alzheimer's disease associated with the STH RR genotype is limited to late-onset Alzheimer's disease a gene within an intron of the tau gene; Q7R polymorphism appears to be over-represented in the homozygous state in late onset Alzheimer's disease subjects | | Human | TET1 | 80312 | tet methylcytosine dioxygenase 1 | Significant association with late-onset Alzheimer's disease for 4 SNPs: rs1881747 near DKK1, rs2279420 in ANK3, rs2306402 in CTNNA3, and rs5030882 in CXXC6 in 1,160 cases and 1,389 controls | | Human | CTNNA3 | 29119 | catenin (cadherin-associated protein), alpha 3 | Alpha-T catenin gene has variants which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in late-onset Alzheimer's disease families CTNNA3 may affect late-onset Alzheimer's disease through a female-specific mechanism independent of the APOE-epsilon4 allele | | Human | PCDH11X | 27328 | protocadherin 11 X-linked | Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease | | Human | BACE1 | 23621 | beta-site APP-cleaving enzyme 1 | Data suggest that BACE1 polymorphism in exon 5 influences risk for late-onset Alzheimer's disease in those carrying the ApoE epsilon4 allele BACE1 gene polymorphism C786G might act as an APOE epsilon4 allele-dependent risk factor for developing late onset Alzheimer's disease in Chinese | | Human | CYP46A1 | 10858 | cytochrome P450, family 46, subfamily A, polypeptide 1 | the polymorphism of CYP46 intron 2 is implicated in the susceptibility to late-onset Alzheimer's disease and a strong synergistic interaction between CYP46 TT homozoygots | | Human | XRCC1 | 7515 | X-ray repair complementing defective repair in Chinese hamster cells 1 | the polymorphic variants of XRCC1 codon 194 have a role in the development of sporadic late-onset Alzheimer's disease | | Human | TNF | 7124 | tumor necrosis factor | Variation in the TNF-alpha promoter region, or possibly polymorphisms in nearby genes, could affect cerebral inflammatory response and the risk of late-onset Alzheimer disease | | Human | SP1 | 6667 | Sp1 transcription factor | Sp1/Egr1-repeat polymorphism in the ALOX5 promoter is not a genetic marker for the risk of developing late-onset Alzheimer disease | | Human | SORL1 | 6653 | sortilin-related receptor, L(DLR class) A repeats containing | Data show that the analysis of allele, genotype and haplotype frequencies reveals no association of SORL1 SNPs with late-onset Alzheimer's disease with in a large Caucasian American case-controls cohort We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease | | Human | RPS3A | 6189 | ribosomal protein S3A | Variants in the RPS3A homologue are associated with late-onset Alzheimer disease and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder | | Human | PSEN2 | 5664 | presenilin 2 (Alzheimer disease 4) | Presenilin 2 Ser130Leu mutation in a case of late-onset "sporadic" Alzheimer's disease We reort a late onset familial Alzheimer's disease: novel presenilin 2 mutation and PS1 E318G polymorphism | | Human | PSEN1 | 5663 | presenilin 1 | We report a late onset familial Alzheimer's disease: novel presenilin 2 mutation and PS1 E318G polymorphism results also suggest that PSEN1 mutations can cause Alzheimer's disease with a large range in age of onset, spanning both early- and late-onset Alzheimer's disease the 1/1 presenilin-1 genotype does not increase the risk of developing late-onset Alzheimer's disease in the Turkish population variable expression not a major determinant of risk for late-onset Alzheimer's disease Presenilin-1 2/2 genotype is a risk factor for late onset Alzheimer disease in the Spanish population, and probably, for Europeans | | Human | PRNP | 5621 | prion protein | Prion protein gene MM genotype increases late-onset Alzheimer's disease risk in Polish population | | Human | PLAU | 5328 | plasminogen activator, urokinase | PLAU is a promising new candidate gene for late-onset Alzheimer's disease, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection Polymorphisms are not associated with late onset Alzheimer's disease Title:Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2.|Association:Y|Conclusion:PLAU is a promising new candidate gene for LOAD, with allele C (P141) being a recessive risk allele or allele T (L141) conferring protection. | | Human | PIN1 | 5300 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | none of the six common SNPs in Pin1, including the two promoter SNPs, rs223678 and rs223679, was associated with increased late-onset Alzheimer's disease risk | | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | These results suggest that the NOS3 gene Glu298Asp polymorphism might be a risk factor for late-onset Alzheimer's disease and dependent on APOE epsilon 4 status in Chinese | | Human | MME | 4311 | membrane metallo-endopeptidase | the GT-repeat polymorphism in the promoter region of the neprilysin gene or some other unknown polymorphisms, which are in a linkage disequilibrium, confer a susceptibility to late-onset Alzheimer's disease | | Human | MEF2A | 4205 | myocyte enhancer factor 2A | The MEF2A gene could be involved in the risk of developing late-onset Alzheimer's disease | | Human | MAPT | 4137 | microtubule-associated protein tau | Our data suggest that the tagged SNPs forming the H1c haplotype at the MAPT locus do not have a causal role in the pathogenesis of late onset Alzheimer's disease | | Human | LRP6 | 4040 | low density lipoprotein receptor-related protein 6 | report the association between common LRP6 variants and late-onset Alzheimer's disease in a multicenter case-control series as well as in a large family-based series ascertained | | Human | NRG1 | 3084 | neuregulin 1 | NRG1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of late onset Alzheimer's disease families | | Human | CFH | 3075 | complement factor H | Variant in this gene may modify susceptibility for late-onset Alzheimer's disease | | Human | GSTT1 | 2952 | glutathione S-transferase theta 1 | The V allele of the GSTP1 may be a risk factor for late-onset Alzheimer's disease, mainly in the presence of the apoE 4 allele, while the presence of GSTT1 may indicate protection against the disease | | Human | GSTP1 | 2950 | glutathione S-transferase pi 1 | The V allele of the GSTP1 may be a risk factor for late-onset Alzheimer's disease, mainly in the presence of the apoE 4 allele, while the presence of GSTT1 may indicate protection against the disease |
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