Genes (367)
Species: human : 365 mouse : 2 | |
Mouse | AMD1 | 262 | adenosylmethionine decarboxylase 1 | We confirmed increased Amd1 expression in RNAs from mouse endometrial carcinomas that were hybridized to GeneChips and validated overexpression of this transcript in additional tumors. | Human | NME1 | 4830 | NME/NM23 nucleoside diphosphate kinase 1 | Click here to display 22 evidence detail records. | Mouse | AMH | 268 | anti-Mullerian hormone | Mullerian inhibiting substance inhibition of a human endometrial carcinoma cell line xenografted in nude mice. | Human | CASC2 | 255082 | cancer susceptibility candidate 2 (non-protein coding) | Identification of a novel candidate gene, CASC2, in a region of common allelic loss at chromosome 10q26 in human endometrial cancer. Identification of CASC2, in a region of common allelic loss at chromosome 10q26 in endometrial cancer | Human | ARMC3 | 219681 | armadillo repeat containing 3 | KU-CT-1 is a new cancer testis antigen that is expressed in pancreatic, lung, and endometrial cancers | Human | FLCN | 201163 | folliculin | Associated endometrial carcinoma, atypical endometrial hyperplasia, uterine leiomyosarcoma, bladder transitional carcinoma, gastric, biliary and renal cell carcinoma | Human | TUBA1C | 84790 | tubulin, alpha 1c | Comparison of the cellular products from organ cultures of endometrial carcinoma, obtained from each subject before and after in vivo administration of medroxyprogesterone acetate (MPA) for 10-14 days revealed: (i) a decrease in the synthesis of tubulin and of a protein of molecular weight (mol. wt) 68 kDa, isoelectric point (pI) 6.0, and (ii) an increase in the synthesis of creatine kinase (CK) and of protein of mol. wt 36 kDa, pI 4, following MPA therapy. | Human | KISS1R | 84634 | KISS1 receptor | Click here to display 7 evidence detail records. | Human | MAML2 | 84441 | mastermind-like 2 (Drosophila) | The expression of Mam-3 antigens in normal human endometrium and endometrial carcinomas was investigated employing the monoclonal antibodies 67D11 (anti Mam-3a), 115H10 (anti Mam-3b), and 115C2 (anti Mam-3c). Human milk-fat globule membrane antigens (Mam-3 group) in normal cycling endometrium and endometrial carcinomas--an immunohistochemical study. | Human | PROK1 | 84432 | prokineticin 1 | EG-VEGF may only play a role in vascular function of peri-implantation endometrium, but is unlikely to be associated with the etiology of endometrial cancer development | Human | C19orf33 | 64073 | chromosome 19 open reading frame 33 | These findings demonstrate the up-regulation of imup-1 and imup-2 in human endometrial carcinomas and indicate that these molecules play a role in endometrial carcinogenesis in both Korean and Japanese patients | Human | KIAA1324 | 57535 | KIAA1324 | Down-regulation of KIAA1324 protein is associated with endometrial cancer | Human | AKR1B10 | 57016 | aldo-keto reductase family 1, member B10 (aldose reductase) | associated with tumor recurrence after surgery and keratinization of squamous cell carcinoma in cervical cancer but not endometrial cancer | Human | CTNNBIP1 | 56998 | catenin, beta interacting protein 1 | stimulation of beta-catenin and suppression of gamma-catenin expression, occur within endometrial carcinomas with squamous differentiation | Human | MMP26 | 56547 | matrix metallopeptidase 26 | Click here to display 9 evidence detail records. | Human | FBXW7 | 55294 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | OBJECTIVE.: Archipelago (AGO, also known as hCdc4, Fbw7, or Sel-10) is an F-box containing component of the SCF complex implicated in the ubiquitination and proteolysis of cyclin E and c-Myc, and found to be mutated in 16% of endometrial carcinomas. OBJECTIVE: Archipelago (AGO, also known as hCdc4, Fbw7, or Sel-10) is an F-box containing component of the SCF complex implicated in the ubiquitination and proteolysis of cyclin E and c-Myc, and found to be mutated in 16% of endometrial carcinomas. | Human | IMP3 | 55272 | IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) | IMP3 may be a useful diagnostic marker in the assessment of endometrial cancers and their precursor lesions | Human | UGT1A1 | 54658 | UDP glucuronosyltransferase 1 family, polypeptide A1 | Click here to display 6 evidence detail records. | Human | UGT1A6 | 54578 | UDP glucuronosyltransferase 1 family, polypeptide A6 | In RL95-2 human endometrial carcinoma cells, SHP inhibited TCDD-stimulated reporter activity from the AHR-responsive CYP1A1 and UGT1A6 gene promoters in a concentration-dependent manner. | Human | WNT4 | 54361 | wingless-type MMTV integration site family, member 4 | The data indicate that all Wnt genes were expressed in vitro, six out of seven Wnt genes (Wnt 2, 3, 4, 5a, 7a and 7b) were expressed endogenously in the human endometrium, their mRNA expression was hormonally independent and Wnt4 gene down-regulation as well as down-regulation of Wnt 2, 3 and 5a may be associated with endometrial carcinoma. Similar to the cell lines, the level of Wnt4 mRNA expression was significantly higher in the normal endometrium than endometrial carcinoma. | Human | ERAP1 | 51752 | endoplasmic reticulum aminopeptidase 1 | Our results suggest that A-LAP is involved in endometrial cancer cell growth and differentiation. Expression of adipocyte-derived leucine aminopeptidase in endometrial cancer. We investigated the expression of A-LAP in endometrial cancer as well as its association with angiogenesis and clinicopathological features. | Human | DSE | 29940 | dermatan sulfate epimerase | SART1(259) antigen was detected in 56%, 35%, and 30% of ovarian, cervical and endometrial cancers, while SART2 antigen was detected in 46%, 66%, and 30% of these cancers, respectively. | Human | PPP2R3B | 28227 | protein phosphatase 2, regulatory subunit B'', beta | CONCLUSION: PP2A activity in the plasma membrane of endometrial cancers might be distinct from that present in the cytosol. The plasma membrane PP2A may be responsible for a rapid and initial decrease in intracellular level of phosphoserine and phosphothreonine, interfering with serine/threonine protein phosphorylation-mediated growth of endometrial cancer. | Human | PELP1 | 27043 | proline, glutamate and leucine rich protein 1 | Using the Ishikawa endometrial cancer model cell line and ER subtype-specific ligands, we found that PELP1 functionally interacts with both ERalpha and ERbeta and enhances their transcriptional responses. PELP1 expression and localization are widely deregulated in endometrial cancers. However, in endometrial cancer cells, endogenous PELP1 is also required for optimal ligand-mediated transcription and proliferation responses. | Human | MLH3 | 27030 | mutL homolog 3 (E. coli) | Associated endometrial carcinoma, atypical endometrial hyperplasia, uterine leiomyosarcoma, bladder transitional carcinoma, gastric, biliary and renal cell carcinoma |
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