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Genes (50)
Species: human : 48 mouse : 2 | |
Mouse | MCC | 4163 | mutated in colorectal cancers | A line (p53-823) derived from a papillary tumor that arose in a mouse with a mutated p53 transgene had a reduced amount of the Mcc gene product only. | Mouse | HOXA9 | 3205 | homeobox A9 | Ectopic expression of Hoxa9 in tumorigenic mouse OSE cells gave rise to papillary tumors resembling serous EOCs. | Human | HOPX | 84525 | HOP homeobox | SMAP31 expression is elevated in 4 of 6 papillary thyroid tumor samples compared to 4 normal thyroid controls | Human | INHBE | 83729 | inhibin, beta E | We have examined the growth regulatory effects of activin A and TGF-beta1 in primary cultures derived from four papillary cancers, two follicular thyroid cancers, and three benign thyroid tissues. | Human | CHEK2 | 11200 | checkpoint kinase 2 | Chk2 inactivation is associated with intraductal papillary mucinous neoplasms of the pancreas | Human | TACC3 | 10460 | transforming, acidic coiled-coil containing protein 3 | The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores. | Human | MAD2L2 | 10459 | MAD2 mitotic arrest deficient-like 2 (yeast) | Chromophobe tumors presented underexpression of MAD1, and MAD2L2, whereas papillary tumors showed overexpression of MAD2L1. | Human | GDF15 | 9518 | growth differentiation factor 15 | MIC-1 has a role in progression of primary pancreatic cancers, intraductal papillary mucinous neoplasms, and pancreatic cancer | Human | FOSL1 | 8061 | FOS-like antigen 1 | METHODS: In 4 types of thyroid tumor that were confirmed by histologic diagnosis after operation (18 cases of adenomatous goiter, 16 cases of follicular adenoma, 30 cases of papillary cancer, 10 cases of follicular cancer), IHC staining method was performed to evaluate the expression of Fra-1. | Human | NCOA4 | 8031 | nuclear receptor coactivator 4 | Among typical papillary tumors, ret/PTC1 was found in 38%, ret/PTC3 in 19%, and ret/PTC2 in 5%. | Human | REEP5 | 7905 | receptor accessory protein 5 | Genomic DNA was extracted from 17 intraductal papillary neoplasms, 6 associated invasive cholangiocarcinomas, and corresponding normal tissues, and microsatellite instability testing was performed using the 5 microsatellite loci recommended by the 1997 National Cancer Institute-sponsored consensus conference (D2S123, D5S346, D17S250, Bat-25, and Bat-26). | Human | VHL | 7428 | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | Report two cases of endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone)with analysis of the VHL gene | Human | TPO | 7173 | thyroid peroxidase | In papillary tumors expression of TPO and Tg mRNA varied from normal to a complete loss of expression of either TPO, Tg or both. | Human | TP53 | 7157 | tumor protein p53 | There are different immunohistochemical expression patterns of p16INK4A and p53 between intraductal papillary-mucinous neoplasm and pancreatic intraepithelial neoplasm p53 may play important role in transition from intraductal papillary-mucinous tumor of the pancreas adenoma to carcinoma in situ p53 mutation is associated with intraductal papillary mucinous neoplasms of the pancreas | Human | NKX2-1 | 7080 | | We focused on the functional relationship existing between Gal-3 and the thyroid-specific transcription factor TTF-1, whose expression is maintained in papillary cancer where it can contribute to the proliferating status. | Human | TGM2 | 7052 | transglutaminase 2 | A proteomic analysis of proteins expressed in intraductal papillary mucinous neoplasms showed that DMBT1 and TGM2 were both upregulated in these lesions | Human | TACC1 | 6867 | transforming, acidic coiled-coil containing protein 1 | The distribution pattern of expression of the two TACC proteins was different, with TACC3 loss being more common in serous papillary carcinoma compared with clear cell carcinomas, while TACC1 staining was less frequent in endometroid than in serous papillary tumor cores. | Human | SYP | 6855 | synaptophysin | One glandular tumor was positive for synaptophysin, and an aggressive papillary tumor was positive for synaptophysin and neuron specific enolase. | Human | STK11 | 6794 | serine/threonine kinase 11 | STK11/LKB1 gene in IPMNs (intraductal papillary-mucinous neoplasms of the pancreas) with LOH revealed a germline mutation in one IPMN that arose in a patient with PJS (Peutz-Jeghers Syndrome) and a somatic mutation in 1 of the 20 sporadic IPMNs | Human | STAT5B | 6777 | signal transducer and activator of transcription 5B | STAT5 protein could contribute to the progression and proliferation of intraductal papillary mucinous neoplasms | Human | SHH | 6469 | sonic hedgehog | SHH and Gli1 mRNAs are likely to be up-regulated from adenoma and from borderline to carcinoma cells, respectively, in intraductal papillary mucinous neoplasm of the pancreas | Human | RBL2 | 5934 | retinoblastoma-like 2 (p130) | Low-grade superficial papillary tumors induced by activated H-ras had no detectable Rb family proteins (Rb, p107, and p130) and late cell cycle cyclins and kinases (cyclin A, E, and CDK1), but had increased level of p16, p53, and MDM2. | Human | PTGS2 | 5743 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | highly expressed in adenoma and adenocarcinoma in intraductal papillary-mucinous tumors of the pancreas | Human | KLK10 | 5655 | kallikrein-related peptidase 10 | In vitro kallikrein 10 secretion was detected in all primary uterine serous papillary carcinoma cell lines tested (mean = 2.7 microg/L), and the secretion levels were not significantly different to those found in primary ovarian serous papillary tumor cultures (mean 4.2 microg/L). Secretion of kallikrein 10 protein by 10 primary tumor cultures including 3 uterine serous papillary carcinomas, 2 endometrioid carcinomas, and 5 ovarian serous papillary tumors was measured using a sensitive ELISA. | Human | KLK6 | 5653 | kallikrein-related peptidase 6 | Human kallikrein 6: a new potential serum biomarker for uterine serous papillary cancer. |
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