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Genes (53)
Species:
human : 53 | |
| Human | KIF6 | 221458 | kinesin family member 6 | Carriers of 719Arg receive significantly greater benefit from intensive statin therapy than do noncarriers, a superior benefit that appears to be due to a mechanism distinct from lipid or CRP lowering | | Human | RETN | 56729 | resistin | CRP could significantly increase resistin expression in cultured human PBMC, and this effect was inhibited by simvastatin, suggesting that CRP and resistin might be involved in the pathogenesis of atherosclerosis | | Human | GP6 | 51206 | glycoprotein VI (platelet) | observed a 3-fold difference in the response to CRP-XL in platelet aggregation when comparing platelets from 10 high-frequency GP6 allele homozygotes with 8 low-frequency ones | | Human | PROCR | 10544 | protein C receptor, endothelial | CRP significantly decreases the expression of thrombomodulin and EPCR in human endothelial cells, thereby promoting thrombogenic conditions | | Human | ADIPOQ | 9370 | adiponectin, C1Q and collagen domain containing | LDL cholesterol (LDL-C), smoking and WBC count are, but levels of adiponectin, insulin and CRP are not significantly related to chronic heart disease death Combination of CRP and HMW-adiponectin reflects further metabolic abnormalities compared with each of them in type 2 diabetic subjects Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of metabolic syndrome in patients with cardiovascular disease or dyslipidemia, adiponectin was independently positively associated with serum HDL-cholesterol, sVCAM-1 (vascular cell adhesion molecule 1), female gender and negatively with hs-CRP (c reative protein) reduced high-molecular-weight adiponectin and elevated high-sensitivity CRP are synergistically associated with the accumulation of metabolic disorders | | Human | VCAM1 | 7412 | vascular cell adhesion molecule 1 | VCAM-1 induction by CRP is mediated by PKC, p38MAPK, tyrosine kinase and the NF-kappaB-dependent signaling pathways in vascular endothelial cells in patients with cardiovascular disease or dyslipidemia, adiponectin was independently positively associated with serum HDL-cholesterol, sVCAM-1 (vascular cell adhesion molecule 1), female gender and negatively with hs-CRP (C reactive protein) | | Human | TNNI1 | 7135 | troponin I type 1 (skeletal, slow) | The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion | | Human | TNFRSF1A | 7132 | tumor necrosis factor receptor superfamily, member 1A | Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI compared with those with CRPS with identical clinical appearance but without hyperalgesia | | Human | TNF | 7124 | tumor necrosis factor | Proinflammatory cytokines seem to be only partly involved in the pathophysiology of complex regional pain syndrome 1, as indicated by the lack of coherence between TNF-alpha and IL-6 levels and the signs and symptoms of inflammation and disease duration Results indicate that IL-6 and TNF-alpha are only partially responsible for the signs and symptoms of complex regional pain syndrome type 1 | | Human | THBD | 7056 | thrombomodulin | CRP significantly decreases the expression of TM and EPCR in human endothelial cells, thereby promoting thrombogenic conditions | | Human | HNF1A | 6927 | HNF1 homeobox A | There are several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype | | Human | SELE | 6401 | selectin E | E-selectin and vWF were not correlated with percent body fat, but were negatively correlated with M (r= -0.65 and -0.46, both P<0.001) and positively correlated with CRP (r=0.46, and 0.33, both P<0.05) Acetylcholine-induced vasodilation in the forearm, but not flow mediated vasodilation, was inversely related to CRP and e-selectin levels independently of traditional risk factors in elderly subjects | | Human | SAA2 | 6289 | serum amyloid A2 | CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock | | Human | S100B | 6285 | S100 calcium binding protein B | Review examines S100B's potential role as a neurologic screening tool, or biomarker of CNS injury, analogous to the role of CRP as a marker of systemic inflammation | | Human | REL | 5966 | v-rel avian reticuloendotheliosis viral oncogene homolog | c-Rel((1-300)) binding to C/EBPbeta increases the affinity of C/EBPbeta for the C/EBP binding site at -53 on the CRP promoter | | Human | MAPK3 | 5595 | mitogen-activated protein kinase 3 | Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2 IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation | | Human | MAPK1 | 5594 | mitogen-activated protein kinase 1 | Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2 | | Human | TNFRSF11B | 4982 | tumor necrosis factor receptor superfamily, member 11b | in obese subjects, OPG is not related to body mass index, however, we describe new relationships between OPG and both HOMA index and CRP | | Human | OLR1 | 4973 | oxidized low density lipoprotein (lectin-like) receptor 1 | CRP increased, through LOX-1, both human monocyte adhesion to aortic endothelial cells and oxLDL uptake by these cells | | Human | NPPB | 4879 | natriuretic peptide B | NT-proBNP levels correlate with PCT and CRP levels in septic patients | | Human | NOS3 | 4846 | nitric oxide synthase 3 (endothelial cell) | although G-CSF induces an inflammatory reaction leading to CRP production, it has direct beneficial effects protecting ECs from the deleterious effects of CRP through activation | | Human | CD46 | 4179 | CD46 molecule, complement regulatory protein | HHV-7 infection causes elevation of the CRPs CD46 and CD59, which may be a possible mechanism for HHV-7 to evade humoral immunity via complement | | Human | LTA | 4049 | lymphotoxin alpha | CRP levels are influenced not only by environmental factors but also by the polymorphism of LTA or other genes in the same haplotype block | | Human | LEPR | 3953 | leptin receptor | Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2 | | Human | LEP | 3952 | leptin | Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2 sex differences in CRP may reflect sex-related differences in the inflammatory responses to obesity, and may in part, be mediated by leptin |
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