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Genes (22)
Species: human : 22 | |
Human | ASPN | 54829 | asporin | Association of the D14 allele with knee osteoarthritis susceptibility in Han Chinese | Human | LRCH1 | 23143 | leucine-rich repeats and calponin homology (CH) domain containing 1 | results suggest that there is no association between LRCH1 and knee osteoarthritis susceptibility A genetic variant in LRCH1 was consistently associated with knee osteoarthritis in 3 samples from 2 populations | Human | PRG4 | 10216 | proteoglycan 4 | In the human knee, cartilaginous deposits and osteoarthritic cartilage contained PRG4 in patients with advanced knee osteoarthritis | Human | KL | 9365 | klotho | An association was observed between SNPs G395A and C2998T of the KLOTHO gene and knee osteoarthritis | Human | GDF5 | 8200 | growth differentiation factor 5 | The results showed a positive association of the GDF5 single-nucleotide polymorphism with knee osteoarthritis for Europeans as well as for Asians | Human | XCL2 | 6846 | chemokine (C motif) ligand 2 | The G carrier of the -2510A/G promoter polymorphism was found to be associated with primary knee knee osteoarthritis among Koreans | Human | PON1 | 5444 | paraoxonase 1 | Serum HDL-cholesterol, -SH levels, paraoxonase & arylesterase activities were significantly lower in patients with knee osteoarthritis than those in controls, while LOOH and low-density lipoprotein (LDL) levels were significantly higher | Human | PLAU | 5328 | plasminogen activator, urokinase | Upregulation of urokinase type plasminogen activator (UroPA) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees | Human | PITX1 | 5307 | paired-like homeodomain 1 | Pitx1 is expressed in normal human knee joint cartilage and its loss occurs in patients with knee osteoarthritis | Human | PEPD | 5184 | peptidase D | oxidative stress and decreased prolidase activity may have a role in pathogenesis of knee osteoarthritis | Human | SERPINE1 | 5054 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Upregulation of plasminogen activator inhibitor (PAI) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees | Human | MMP9 | 4318 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Upregulation of matrix metalloproteinase-9 (MMP-9) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees | Human | MMP2 | 4313 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Upregulation of matrix metalloproteinase-2 (MMP-2) expression during early development of knee osteoarthritis (OA) occurs via MAPK ERK, JNK, and p38 signaling pathways and the PI3K signaling pathway in cultured cells debrided from OA knees | Human | IL1RN | 3557 | interleukin 1 receptor antagonist | study suggests that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients & are unrelated to clinical, radiological & laboratory characteristics of knee osteoarthritis Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis High endogenous IL-1Ra (interleukin 1 receptor antagonist) /IL-1beta ratio occurs in synovial fluid from knee osteoarthritis; it does not correlate with pain or Lequesne index | Human | IL1B | 3553 | interleukin 1, beta | High endogenous IL-1Ra (interleukin 1 receptor antagonist) /IL-1beta ratio occurs in synovial fluid from knee osteoarthritis; it does not correlate with pain or Lequesne index study suggests that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients & are unrelated to clinical, radiological & laboratory characteristics of knee osteoarthritis | Human | IL1A | 3552 | interleukin 1, alpha | study suggests that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients & are unrelated to clinical, radiological & laboratory characteristics of knee osteoarthritis Title:Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis.|Association:Y|Conclusion:The IL-1 ligand cluster encodes for susceptibility to knee OA but not to hip OA, highlighting the genetic heterogeneity of this common, complex disease. | Human | LPAR1 | 1902 | lysophosphatidic acid receptor 1 | Through the stepwise association study, an SNP located in the promoter region of EDG2 (-2,820G/A; rs10980705) showed significant association with knee osteoarthritis in two independent populations | Human | ACE | 1636 | angiotensin I converting enzyme | did not find an association between ACE gene I/D polymorphism genotypes in Kuwaiti patients with primary knee osteoarthritis | Human | COMP | 1311 | cartilage oligomeric matrix protein | there is an inverse relationship between hypermobility and hand and knee osteoarthritis, and that hypermobility is associated with lower serum COMP levels | Human | COL9A2 | 1298 | collagen, type IX, alpha 2 | | Human | CALM1 | 801 | calmodulin 1 (phosphorylase kinase, delta) | The present study suggests that the CALM1 core promoter polymorphism -16C/T is not a risk factor for knee osteoarthritis susceptibility in the Chinese Han population | Human | RHOB | 388 | ras homolog family member B | The minor allele frequency of RHOB in East Asian individuals is much lower than that of European Caucasians; a definite association of RHOB with knee osteoarthritis in East Asian individuals is not detected |
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