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Details
Link-It Detail - Disease - Osteoarthritis, Knee
Debug Stats
  • ### Total Build Time: 143 ms 48.105 KB
  • CONCEPT_NAME gt=4 ms Completed: 4 ms rowSize= 338 bytes
  • CONCEPT_SOLR_HIT_STATS gt=0 Completed: 0 ms rowSize= 14 bytes
  • CONCEPT_DEFINITION gt=0 Completed: 0 ms rowSize= 503 bytes
  • Skipping details on: CONCEPT_SYNONYM gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • Skipping details on: CONCEPT_TEXT gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_SEMANTIC_TYPE gt=1 ms Completed: 1 ms rowSize= 188 bytes
  • Skipping details on: CONCEPT_NAMESPACE gt=NONE 0 Completed: 0 ms rowSize= 0 bytes
  • CONCEPT_PARENTS gt=8 ms Completed: 8 ms rowSize= 550 bytes
  • CONCEPT_CHILDREN gt=0 Completed: 0 ms rowSize= 8 bytes
  • CONCEPT_ANCESTRAL_ROOTS gt=0 Completed: 0 ms rowSize= 4.059 KB
  • CONCEPT_RELATIONSHIPS gt=83 ms Completed: 83 ms rowSize= 13.271 KB
  • CONCEPT_GENES gt=42 ms Completed: 42 ms rowSize= 28.044 KB
  • CONCEPT_XREFS gt=4 ms Completed: 4 ms rowSize= 1.154 KB
  • CONCEPT_ANCILLARY gt=1 ms Completed: 1 ms rowSize= 14 bytes
  • Reload Stats
Disease (1)
Osteoarthritis, Knee C0409959
Definition (1)
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Semantic Types (1)
Disease or Syndrome (T047)
Parents (1)
img Osteoarthritis C0029408
Ancestral Roots
RootRoot Plus OneDepthParent
img Musculoskeletal Diseases C0026857img Joint Diseases C00224085img Osteoarthritis C0029408
img Skin and Connective Tissue Diseases C0175166img Connective Tissue Diseases C00097825img Osteoarthritis C0029408
img Musculoskeletal Diseases C0026857img Rheumatic Diseases C00354354img Osteoarthritis C0029408
Relationships (104)

Relation Types:
diso_​to_​anat : 30
diso_​to_​chem : 26
diso_​to_​diso : 37
diso_​to_​gene : 1
diso_​to_​phen : 3
diso_​to_​phys : 7


Relationships:
none : 102
isa : 1
permuted_​term_​of : 1
Page Size
Current 25
  Page 1 of 5
Prior Page
Current 1
Relation TypeCo-Occuring
Concept Count
RelationshipConcept
DISO_to_ANAT772img Knee Joint C0022745
DISO_to_DISO485img Complication Aspects C1171258
DISO_to_DISO418img Osteoarthritis of hip C0029410
DISO_to_ANAT412img Cartilage, Articular C0007303
DISO_to_ANAT292img Knee Joint C0022745
DISO_to_DISO221img Complication Aspects C1171258
DISO_to_ANAT216img Cartilage, Articular C0007303
DISO_to_DISO194img Osteoarthritis of hip C0029410
DISO_to_DISO194img Pain C0030193
DISO_to_ANAT180img Bone structure of tibia C0040184
DISO_to_PHEN143img genetic aspects C0017399
DISO_to_CHEM142img Hyaluronic Acid C0020196
DISO_to_PHYS133img Range of Motion, Articular C0080078
DISO_to_DISO128img Gait C0016928
DISO_to_ANAT125img Cartilage, Semilunar C0025313
DISO_to_CHEM124img Hyaluronic Acid C0020196
DISO_to_ANAT122img Bone structure of tibia C0040184
DISO_to_ANAT115img Chondrocyte C0225369
DISO_to_DISO114img Arthralgia C0003862
DISO_to_DISO111img Pain C0030193
DISO_to_ANAT96img In Blood C0005768
DISO_to_DISO96img INJ KNEE C0022744
DISO_to_CHEM89img 603-604 NON-STEROIDAL ANTI-INFLAMMATORY AGENTS C0003211
DISO_to_DISO88img Obesity C0028754
DISO_to_ANAT85img Synovial Fluid C0039097
Genes (22)

Species:
human : 22
SpeciesGeneGeneIdGene NameEvidence
HumanASPN54829asporin
img GENERIF, Score=734, Pubmed Id: 17024313, UMLKSK CUI: C0409959
HumanLRCH123143leucine-rich repeats and calponin homology (CH) domain containing 1
img GENERIF, Score=734, Pubmed Id: 18049793, UMLKSK CUI: C0409959
img GENERIF, Score=1000, Pubmed Id: 16447229, UMLKSK CUI: C0409959
HumanPRG410216proteoglycan 4
img GENERIF, Score=901, Pubmed Id: 17343281, UMLKSK CUI: C0409959
HumanKL9365klotho
img GENERIF, Score=1000, Pubmed Id: 18465812, UMLKSK CUI: C0409959
HumanGDF58200growth differentiation factor 5
img GENERIF, Score=1000, Pubmed Id: 18299287, UMLKSK CUI: C0409959
HumanXCL26846chemokine (C motif) ligand 2
img GENERIF, Score=875, Pubmed Id: 17763208, UMLKSK CUI: C0409959
HumanPON15444paraoxonase 1
img GENERIF, Score=1000, Pubmed Id: 18796237, UMLKSK CUI: C0409959
HumanPLAU5328plasminogen activator, urokinase
img GENERIF, Score=1000, Pubmed Id: 17299841, UMLKSK CUI: C0409959
HumanPITX15307paired-like homeodomain 1
img GENERIF, Score=1000, Pubmed Id: 17549029, UMLKSK CUI: C0409959
HumanPEPD5184peptidase D
img GENERIF, Score=1000, Pubmed Id: 17096092, UMLKSK CUI: C0409959
HumanSERPINE15054serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
img GENERIF, Score=1000, Pubmed Id: 17299841, UMLKSK CUI: C0409959
HumanMMP94318matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
img GENERIF, Score=1000, Pubmed Id: 17299841, UMLKSK CUI: C0409959
HumanMMP24313matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
img GENERIF, Score=1000, Pubmed Id: 17299841, UMLKSK CUI: C0409959
HumanIL1RN3557interleukin 1 receptor antagonist
img GENERIF, Score=1000, Pubmed Id: 17716546, UMLKSK CUI: C0409959
img GENERIF, Score=1000, Pubmed Id: 18597398, UMLKSK CUI: C0409959
img GENERIF, Score=1000, Pubmed Id: 12115182, UMLKSK CUI: C0409959
HumanIL1B3553interleukin 1, beta
img GENERIF, Score=1000, Pubmed Id: 18597398, UMLKSK CUI: C0409959
img GENERIF, Score=1000, Pubmed Id: 17716546, UMLKSK CUI: C0409959
HumanIL1A3552interleukin 1, alpha
img GENERIF, Score=1000, Pubmed Id: 17716546, UMLKSK CUI: C0409959
img GAD, Score=1000, Pubmed Id: 12115182, UMLKSK CUI: C0409959
HumanLPAR11902lysophosphatidic acid receptor 1
img GENERIF, Score=1000, Pubmed Id: 18325907, UMLKSK CUI: C0409959
HumanACE1636angiotensin I converting enzyme
img GENERIF, Score=901, Pubmed Id: 18565253, UMLKSK CUI: C0409959
HumanCOMP1311cartilage oligomeric matrix protein
img GENERIF, Score=1000, Pubmed Id: 19035482, UMLKSK CUI: C0409959
HumanCOL9A21298collagen, type IX, alpha 2
img OMIM, Score=1000, UMLKSK CUI: C0409959
HumanCALM1801calmodulin 1 (phosphorylase kinase, delta)
img GENERIF, Score=734, Pubmed Id: 18940010, UMLKSK CUI: C0409959
HumanRHOB388ras homolog family member B
img GENERIF, Score=1000, Pubmed Id: 18471322, UMLKSK CUI: C0409959
XRefs (1)

XRef Types:
cui : 1


ToppGene Datasets:
none : 1
ToppGene DatasetsXRef TypeXRef IdXRefValuesSourceTop % Rank
CUIimg C0409959Osteoarthritis, Knee0self